Results 11 to 20 of about 760 (141)

KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence [PDF]

Frontiers in Physiology, 2019
Shear stress, a blood flow-induced frictional force, is essential in the control of endothelial cell (EC) homeostasis. High laminar shear stress (HLSS), as observed in straight parts of arteries, assures a quiescent non-activated endothelium through the ...
Jean-François Denis, Mannekomba R. Diagbouga, Filippo Molica, Aurélie Hautefort, Tanja Linnerz, Masakatsu Watanabe, Sylvain Lemeille, Julien Y. Bertrand, Brenda R. Kwak, Brenda R. Kwak   +9 more
doaj   +2 more sources

Atrial fibrillation-linked germline GJA5/connexin40 mutants showed an increased hemichannel function.

PLoS ONE, 2014
Mutations in GJA5 encoding the gap junction protein connexin40 (Cx40) have been linked to lone atrial fibrillation. Some of these mutants result in impaired gap junction function due to either abnormal connexin localization or impaired gap junction ...
Yiguo Sun, Matthew D Hills, Willy G Ye, Xiaoling Tong, Donglin Bai   +4 more
doaj   +2 more sources

Functional consequences of co-expressing connexin40 or connexin45 with connexin43 on intercellular electrical coupling [PDF]

, 2017
The functional characteristics of the co-expression of connexin43, connexin40, and connexin45 proteins in human myocardium are thought to play an important role in governing normal propagation of the cardiac electrical impulse and in generating the ...
Severs, Nicholas J., Dupont, Emmanuel, Desplantez, Thomas, Macleod, Kenneth T., Thomas, Neil M., Peters, Nicholas S., Gray, Rosaire, Fry, Christopher H.   +7 more
core   +3 more sources

Hypertension in connexin40-null mice: a renin disorder [PDF]

, 2007
Studies described in this issue indicate that the gap junction protein connexin40 (Cx40) appears to play an unexpected role in blood pressure regulation.
Spray, D.C.
core   +1 more source

Histone deacetylase inhibition reduces cardiac Connexin43 expression and gap junction communication

Frontiers in Pharmacology, 2013
Histone deactylase (HDAC) inhibitors are being investigated as novel therapies for cancer, inflammation, neurodegeneration, and heart failure. The effects of HDAC inhibitors on the functional expression of cardiac gap junctions (GJ) are essentially ...
Qin eXu, Xianming eLin, Xianming eLin, Laura eAndrews, Dakshesh ePatel, Paul D Lampe, Richard David Veenstra   +6 more
doaj   +1 more source

Endothelial-specific deletion of Connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion [PDF]

, 2010
Background— Endothelial dysfunction is the initiating event of atherosclerosis. The expression of connexin40 (Cx40), an endothelial gap junction protein, is decreased during atherogenesis.
de Wit, C, Wit, C. de, Chadjichristos, C E, Kempen, M.J.A. van, Chanson, M., Kwak, B R, Richani Sarieddine, Maya, Coenjaerts, F.E.J., Jongsma, H. J., van Veen, T.A.B., Yang, Z., Chadjichristos, C.E., Coenjaerts, F E J, Dudez, Tecla, Roth, I, Bacchetta, Marc, Coenjaerts, F. E., Veen, T.A.B. van, Kwak, B.R., Chanson, M, Yang, Z, Foglia, Bernard, van Kempen, M.J.A., Deutsch, U., van Veen, T A B, Bacchetta, M, Miquerol, L., Scheckenbach, K E L, Dudez, T., Roth, I., Jongsma, H J, Scheckenbach, K E. L., Viswambharan, H., Scheckenbach, K.E.L., Chanson, Marc, Chadjichristos, Christos, Foglia, B, Foglia, B., de Wit, C., Deutsch, U, Bacchetta, M., Kwak, Brenda, Viswambharan, Hema, Miquerol, L, Yang, Zhihong, van Kempen, M. J., Viswambharan, H, van Kempen, M J A, Jongsma, H.J., Dudez, T, van Veen, T. A., Richani Sarieddine, M.Z., Richani Sarieddine, M Z   +52 more
core   +2 more sources

Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart. [PDF]

PLoS ONE, 2017
The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy.
Willemijn van Eldik, Brigit den Adel, Jantine Monshouwer-Kloots, Daniela Salvatori, Saskia Maas, Ingeborg van der Made, Esther E Creemers, Derk Frank, Norbert Frey, Nicky Boontje, Jolanda van der Velden, Paul Steendijk, Christine Mummery, Robert Passier, Abdelaziz Beqqali   +14 more
doaj   +1 more source

Toll‐Like Receptor‐Mediated Cardiac Injury during Experimental Sepsis

Mediators of Inflammation, Volume 2020, Issue 1, 2020., 2020
Sepsis is associated with global cardiac dysfunction and with high mortality rate. The development of septic cardiomyopathy is due to complex interactions of damage‐associated molecular patters, cytokines, and complement activation products. The aim of this study was to define the effects of sepsis on cardiac structure, gap junction, and tight junction
Ina Lackner, Birte Weber, Shinjini Chakraborty, Sonja Braumüller, Markus Huber-Lang, Florian Gebhard, Miriam Kalbitz, Jacek Cezary Szepietowski   +7 more
wiley   +1 more source

Connexins and M3 Muscarinic Receptors Contribute to Heterogeneous Ca2+ Signaling in Mouse Aortic Endothelium

Cellular Physiology and Biochemistry, 2013
Background/Aims: Smooth muscle tone is controlled by Ca2+ signaling in the endothelial layer. Mouse endothelial cells are interconnected by gap junctions made of Connexin40 (Cx40) and Cx37, which allow the exchange of signaling molecules to coordinate ...
François-Xavier Boittin, Florian Alonso, Loïc Le Gal, Florent Allagnat, Jean-Louis Bény, Jacques-Antoine Haefliger   +5 more
doaj   +1 more source

An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels

Disease Models & Mechanisms, 2014
Connexin40 (Cx40)-containing gap-junction channels are expressed in the atrial myocardium and provide a low-resistance passage for rapid impulse propagation.
Yiguo Sun, Xiaoling Tong, Honghong Chen, Tao Huang, Qing Shao, Weixiong Huang, Dale W. Laird, Donglin Bai   +7 more
doaj   +1 more source