Results 51 to 60 of about 760 (141)

Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins

Brazilian Journal of Medical and Biological Research, 2000
Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties.
Beyer E.C., Gemel J., Seul K.H., Larson D.M., Banach K., Brink P.R.   +5 more
doaj  

Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45

, 2006
Connexin40 (Cx40) and connexin45 (Cx45) are involved in both cardiac morphogenesis and propagation of electrical activity. We found that Cx40/Cx45 double deficiency (Cx40(-/-)/Cx45(+/-)) causes a variety of cardiac defects leading to high mortality ...
Tiemann, Klaus, Lüderitz, Bernd, van Rijen, Harold V. M., Krüger, Olaf, Willecke, Klaus, Kim, Jung-Sun, Ghanem, Alexander, de Bakker, Jacques M. T., Lewalter, Thorsten, Maxeiner, Stephan, Eckardt, Dominik   +10 more
core   +1 more source

Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice [PDF]

, 1998
Intercellular channels of gap junctions are formed in vertebrates by the protein family of connexins and allow direct exchange of ions, metabolites and second messenger molecules between apposed cells (reviewed in [1–3]).
Hagendorff, Andreas, Nelles, Eric, Traub, Otto, Krüger, Olaf, Willecke, Klaus, Kirchhoff, Susanne   +5 more
core   +1 more source

Reduced connexin40 protein expression in the right atrial appendage of patients bearing the minor connexin40 allele (-44 G -> A)

, 2012
The occurrence of connexin40 (Cx40) minor polymorphism (44 G A) was increased in patients with idiopathic atrial fibrillation (AF), although its effect on atrial Cx40 protein expression is unknown.
Hauer, Richard N. W., van Rijen, Harold V. M., Nelen, Marcel, Hubens, Lisette E. G., Bierhuizen, Marti F. A., Chaldoupi, Sevasti-Maria, de Bakker, Jacques M. T., Loh, Peter, van Veen, Toon A. B., Smit Duijzentkunst, Daan A., van Stuijvenberg, Leonie, van Aarnhem, Egidius E. H. L.   +11 more
core   +1 more source

Table_1_KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence.DOCX

, 2019
Shear stress, a blood flow-induced frictional force, is essential in the control of endothelial cell (EC) homeostasis. High laminar shear stress (HLSS), as observed in straight parts of arteries, assures a quiescent non-activated endothelium through the ...
Julien Y. Bertrand (6322859), Mannekomba R. Diagbouga (6322850), Filippo Molica (5008826), Tanja Linnerz (6322856), Masakatsu Watanabe (144065), Brenda R. Kwak (4264510), Jean-François Denis (6322847), Aurélie Hautefort (6322853), Sylvain Lemeille (7986)   +8 more
core   +1 more source

Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block [PDF]

, 1998
Activation of cardiac muscle is mediated by the His–Purkinje system, a discrete pathway containing fast-conducting cells (Purkinje fibers) which coordinate the spread of excitation from the atrioventricular node (AV node) to ventricular myocardium [1 ...
Paul, David L., Simon, Alexander M., Goodenough, Daniel A.   +2 more
core   +1 more source

Vascular Abnormalities in Mice Lacking the Endothelial Gap Junction Proteins connexin37 and connexin40 [PDF]

, 2002
Cells within the vascular wall are coupled by gap junctions, allowing for direct intercellular transfer of low molecular weight molecules. Although gap junctions are believed to be important for vascular development and function, their precise roles are ...
McWhorter, Andrea R., Simon, Alexander M.   +1 more
core   +1 more source

Association Study on Connexin40 Genetic Polymorphism and Atrial Fibrillation

, 2007
背景 心房顫動（Atrial Fibrillation, AF）屬於最常見的心律不整， 常伴隨有心悸、胸痛、頭暈的症狀，且容易引起中風、心臟衰竭，及引發死亡的危險。曾有研究顯示，心房顫動與先天遺傳因素相關，而由於心臟細胞中構成間隙連接的分子，connexin40 與心肌間的電氣傳導有關，因此我們探討connexin40 的基因多型性與心房顫動間的關係。 病患與方法 本實驗主要研究connexin40(Cx40 -44G>A 與Cx40 71A>G)的單一 核苷酸多型性與心房顫動的關聯性 ...
Chen, Yi-Jung, 陳怡蓉
core  

Who and where is the renal baroreceptor?: the connexin hypothesis [PDF]

, 2009
Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al.
Gomez, R. Ariel, Sequeira Lopez, Maria Luisa S.   +1 more
core   +1 more source

Table1_Reduced tubuloglomerular feedback activity and absence of its synchronization in a connexin40 knockout rat.DOCX

, 2023
Introduction: Tubuloglomerular feedback (TGF) is the negative feedback component of renal blood flow (RBF) autoregulation. Neighbouring nephrons often exhibit spontaneous TGF oscillation and synchronization mediated by endothelial communication, largely ...
Branko Braam (137873), Heather L. More, Heather L. More (5597687), William A. Cupples (12044738), Branko Braam, William A. Cupples   +5 more
core   +1 more source