Results 11 to 20 of about 4,332 (134)

Effects of an Atypical Antipsychotic, Zotepine, on Astroglial L-Glutamate Release through Hemichannels: Exploring the Mechanism of Mood-Stabilising Antipsychotic Actions and Antipsychotic-Induced Convulsion

Pharmaceuticals, 2021
Accumulating neuropsychopharmacological evidence has suggested that functional abnormalities of astroglial transmission and protein kinase B (Akt) contribute to the pathophysiology and/or pathomechanisms of several neuropsychiatric disorders, such as ...
Kouji Fukuyama, Motohiro Okada
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Connexin 43: a New Therapeutic Target Against Chronic Kidney Disease

Cellular Physiology and Biochemistry, 2018
Chronic kidney disease is an incurable to date pathology with a continuously growing incidence that contributes to the increase of the number of deaths worldwide.
Niki Prakoura, Panagiotis Kavvadas, Christos E.  Chadjichristos   +2 more
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Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43

Frontiers in Pharmacology, 2020
Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H2O2-induced dermal fibroblast damage. Our results show
Ying Chen, Ying Chen, Huazhong Liu, Hao Huang, Yuetang Ma, Ruihua Wang, Yong Hu, Xiufen Zheng, Chunmei Chen, Hongfeng Tang   +9 more
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Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging

Cell Reports, 2019
Summary: Connexin43 (Cx43; gene name GJA1) is the most ubiquitously expressed gap junction protein, and understanding of its regulation largely falls under transcription and post-translational modification.
Michael J. Zeitz, Patrick J. Calhoun, Carissa C. James, Thomas Taetzsch, Kijana K. George, Stefanie Robel, Gregorio Valdez, James W. Smyth   +7 more
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Corrigendum: Characterization of pannexin1, connexin32, and connexin43 in spotted sea bass (Lateolabrax maculatus): they are important neuro-related immune response genes involved in inflammation-induced ATP release [PDF]

Frontiers in Immunology
Zhaosheng Sun, Zhaosheng Sun, Zhaosheng Sun, Chong Xu, Chong Xu, Chong Xu, Yuxi Chen, Yuxi Chen, Yuxi Chen, Danjie Liu, Danjie Liu, Danjie Liu, Ping Wu, Qian Gao, Qian Gao, Qian Gao   +15 more
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Fibronectin and Cyclic Strain Improve Cardiac Progenitor Cell Regenerative Potential In Vitro

Stem Cells International, 2016
Cardiac progenitor cells (CPCs) have rapidly advanced to clinical trials, yet little is known regarding their interaction with the microenvironment. Signaling cues present in the microenvironment change with development and disease.
Kristin M. French, Joshua T. Maxwell, Srishti Bhutani, Shohini Ghosh-Choudhary, Marcos J. Fierro, Todd D. Johnson, Karen L. Christman, W. Robert Taylor, Michael E. Davis   +8 more
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Calmodulin Directly Interacts with the Cx43 Carboxyl-Terminus and Cytoplasmic Loop Containing Three ODDD-Linked Mutants (M147T, R148Q, and T154A) that Retain α-Helical Structure, but Exhibit Loss-of-Function and Cellular Trafficking Defects

Biomolecules, 2020
The autosomal-dominant pleiotropic disorder called oculodentodigital dysplasia (ODDD) is caused by mutations in the gap junction protein Cx43. Of the 73 mutations identified to date, over one-third are localized in the cytoplasmic loop (Cx43CL) domain ...
Li Zheng, Sylvie Chenavas, Fabien Kieken, Andrew Trease, Sarah Brownell, Asokan Anbanandam, Paul L. Sorgen, Gaelle Spagnol   +7 more
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Novel GJA1/Cx43 Variant Associated With Oculo-Dento-Digital Dysplasia Syndrome: Clinical Phenotype and Cellular Mechanisms

Frontiers in Genetics, 2021
Oculodentodigital dysplasia syndrome is associated with numerous pathogenic variants in GJA1, the gene encoding connexin43 gap junction protein. A novel in-frame deletion (p.Lys134del) was found in our clinic.
Irene Sargiannidou, Violetta Christophidou-Anastasiadou, Violetta Christophidou-Anastasiadou, Andreas Hadjisavvas, George A. Tanteles, Kleopas A. Kleopa, Kleopas A. Kleopa, Kleopas A. Kleopa   +7 more
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Effect of Aerobic Exercise on Left Ventricular Connexin43 Expression and Distribution in Juvenile and Young Adult Rats

Journal of Biomedicine and Translational Research, 2021
Background: Gap Junction (GJ) plays a role in supporting the heart electricity. Connexin43 (Cx43) as the main protein constituent of GJ in left cardiac ventricle, will increase in number and slightly redistributed to the lateral sides of cardiomyocytes ...
Rustiana Tasya Ariningpraja, ‪Dewi Irawati Soeria Santoso, Ahmad Aulia Jusuf, Alfrina Hany   +3 more
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Oscillating Pressure Treatment Upregulates Connexin43 Expression in Skeletal Myoblasts and Enhances Therapeutic Efficacy for Myocardial Infarction

Cell Transplantation, 2009
Transplantation of autologous skeletal myoblasts (SMBs) is a potential therapeutic approach for myocardial infarction. However, their clinical efficacy and safety is still controversial.
Sae-Won Lee, Hyun-Jae Kang, Ji-Young Lee, Seock-Won Youn, Joo-Yun Won, Ji-Hyun Kim, Hyun-Chae Lee, Eun Ju Lee, Se-Il Oh, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim M.D., Ph.D.   +11 more
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