Results 21 to 30 of about 4,332 (134)

Peptidic Connexin43 Therapeutics in Cardiac Reparative Medicine

Journal of Cardiovascular Development and Disease, 2021
Connexin (Cx43)-formed channels have been linked to cardiac arrhythmias and diseases of the heart associated with myocardial tissue loss and fibrosis.
Spencer R. Marsh, Zachary J. Williams, Kevin J. Pridham, Robert G. Gourdie   +3 more
doaj   +1 more source

Increased cell-cell coupling increases infarct size and does not decrease incidence of ventricular tachycardia in mice

Frontiers in Physiology, 2011
Increasing Connexin43 (Cx43) gap junctional conductance as a means to improve cardiac conduction has been proposed as a novel antiarrhythmic modality. Yet, transmission of molecules via gap junctions may be associated with increased infarct size.
Kevin A Prestia, Eugene A Sosunov, Evgeny P Anyukhovsky, Elena eDolmatova, Caitlin W Kelly, Peter R Brink, Richard B Robinson, Michael R Rosen, Heather S. eDuffy   +8 more
doaj   +1 more source

Inhibition of connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory

Frontiers in Cellular Neuroscience, 2016
Astrocytes are active players in higher brain function as they can release gliotransmitters, which are essential for synaptic plasticity. Various mechanisms have been proposed for gliotransmission, including vesicular mechanisms as well as non-vesicular ...
Laura Walrave, Mathieu Vinken, Giulia Albertini, Dimitri De Bundel, Luc Leybaert, Ilse Julia Smolders   +5 more
doaj   +1 more source

Synthesis and Biological Evaluation of Termini-Modified and Cyclic Variants of the Connexin43 Inhibitor Peptide5

Frontiers in Chemistry, 2022
Peptide5 is a 12–amino acid mimetic peptide that corresponds to a region of the extracellular loop 2 (EL2) of connexin43. Peptide5 regulates both cellular communication with the cytoplasm (hemichannels) and cell-to-cell communication (gap junctions), and
Sin Hang Crystal Chan, Jarred M. Griffin, Connor A. Clemett, Margaret A. Brimble, Margaret A. Brimble, Margaret A. Brimble, Simon J. O’Carroll, Paul W. R. Harris, Paul W. R. Harris, Paul W. R. Harris   +9 more
doaj   +1 more source

Lack of connexin43-mediated Bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning

Frontiers in Behavioral Neuroscience, 2008
Bergmann glial cells are specialized astrocytes in the cerebellum. In the mature cerebellar molecular layer, Bergmann glial processes are closely associated with Purkinje cells, enclosing Purkinje cell dendritic synapses with a glial sheath.
Mika Tanaka, Kazuhiko Yamaguchi, Tetsuya Tatsukawa, Chieko Nishioka, Chieko Nishioka, Hiroshi Nishiyama, Martin Theis, Martin Theis, Klaus Willecke, Shigeyoshi Itohara   +9 more
doaj   +1 more source

18-α-glycyrrhetinic acid alleviates oxidative damage in periodontal tissue by modulating the interaction of Cx43 and JNK/NF-κB pathways

Frontiers in Pharmacology, 2023
Objective: Periodontitis is a common chronic inflammatory disease in which oxidative stress is one of the key pathogenic factors. Connexin43 (Cx43) is the most critical and widely distributed connexin isoform.
Niuben Cao, Xiaomeng Liu, Yubo Hou, Yu Deng, Yu Xin, Xirui Xin, Xinchen Xiang, Xinchan Liu, Weixian Yu, Weixian Yu   +9 more
doaj   +1 more source

Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload

Frontiers in Physiology, 2016
Volume overload leads to development of eccentric cardiac hypertrophy and heart failure. In our previous report, we have shown myocyte hypertrophy with no fibrosis and decrease in gap junctional coupling via connexin43 in a rat model of aorto-caval ...
David Sedmera, David Sedmera, Jan Neckar, Jiri Benes, Jiri Benes, Jiri Benes, Jana Pospisilova, Jiri Petrak, Kamil Sedlacek, Vojtech Melenovsky   +9 more
doaj   +1 more source

Interfering amino terminal peptides and functional implications for heteromeric gap junction formation

Frontiers in Pharmacology, 2013
Connexin43 (Cx43) is widely expressed in many different tissues of the human body. In cells of some organs, Cx43 is co-expressed with other connexins (Cx), including Cx46 and Cx50 in lens, Cx40 in atrium, Purkinje fibers, and the blood vessel wall, Cx45 ...
Richard David Veenstra, Xianming eLin, Eric C Beyer   +2 more
doaj   +1 more source

Danegaptide Enhances Astrocyte Gap Junctional Coupling and Reduces Ischemic Reperfusion Brain Injury in Mice

Biomolecules, 2020
Ischemic stroke is a complex and devastating event characterized by cell death resulting from a transient or permanent arterial occlusion. Astrocytic connexin43 (Cx43) gap junction (GJ) proteins have been reported to impact neuronal survival in ischemic ...
Moises Freitas-Andrade, John Bechberger, Jasmine Wang, Ken K.C. Yeung, Shawn N. Whitehead, Rie Shultz Hansen, Christian C. Naus   +6 more
doaj   +1 more source

Aerobic exercise increases connexin43 expression in rat cardiac muscle

Universa Medicina, 2015
Background Intercellular communication in cardiac muscle is effected by connexin, particularly connexin43 (Cx43), forming gap junctions in cardiomyocytes. Aerobic physical exercise may result in increased left ventricular size and function.
Fransisca Chondro, Minarma Siagian, Dewi IS Santoso   +2 more
doaj   +1 more source