Results 41 to 50 of about 4,332 (134)

Intercalated Disk Extracellular Nanodomain Expansion in Patients With Atrial Fibrillation

Frontiers in Physiology, 2018
Aims: Atrial fibrillation (AF) is the most common sustained arrhythmia. Previous evidence in animal models suggests that the gap junction (GJ) adjacent nanodomain – perinexus – is a site capable of independent intercellular communication via ephaptic ...
Tristan B. Raisch, Tristan B. Raisch, Matthew S. Yanoff, Matthew S. Yanoff, Timothy R. Larsen, Mohammed A. Farooqui, D. Ryan King, D. Ryan King, Rengasayee Veeraraghavan, Rengasayee Veeraraghavan, Rengasayee Veeraraghavan, Robert G. Gourdie, Robert G. Gourdie, Joseph W. Baker, William S. Arnold, Soufian T. AlMahameed, Steven Poelzing, Steven Poelzing, Steven Poelzing   +18 more
doaj   +1 more source

Pulmonary Hypertension Molecular Switch: HIF Signaling Pathway

Pulmonary Circulation, Volume 16, Issue 3, July 2026.
ABSTRACT Pulmonary hypertension (PH) is a multifaceted disorder characterized by the crucial involvement of activated hypoxia‐inducible factors (HIFs). Recent investigations have unveiled HIFs' ability to orchestrate a wide array of signaling cascades, encompassing voltage‐gated potassium channels, non‐selective cation channels (NSCCs), Ca2+/PKC/MAPKs,
Yinhui Sun, Rongzhen Ding, Xianli Su, Li Qin, Lihuai Wang, Jian Yi, Ruicheng Hu, Shuying You, Zhenfei Tan, Aiguo Dai   +9 more
wiley   +1 more source

Beneficial Electrophysiological Effects of Rotigaptide Are Unable to Suppress Therapeutic Hypothermia-Provoked Ventricular Fibrillation in Failing Rabbit Hearts With Acute Ischemia–Reperfusion Injury

Frontiers in Physiology, 2021
Aims: Whether therapeutic hypothermia (TH) is proarrhythmic in preexisting failing hearts with acute ischemia–reperfusion (IR) injury is unknown. Additionally, the effectiveness of rotigaptide on improving conduction slowing in hearts with IR injury is ...
Hui-Ling Lee, Po-Cheng Chang, Hung-Ta Wo, Hao-Tien Liu, Ming-Shien Wen, Ming-Shien Wen, Chung-Chuan Chou, Chung-Chuan Chou   +7 more
doaj   +1 more source

Serotonin 5‐HT7 receptor signaling in neuropsychiatric disorders

Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 698-710, June 2026.
5‐HT7R recruits Gs, G12, and β‐arrestin signaling to regulate neuronal plasticity, circuit function, and kinase‐linked intracellular responses. This review summarizes how these pathway‐selective modules contribute to autism spectrum disorder, depression, and schizophrenia, highlighting 5‐HT7R as a pathway‐informed therapeutic target. Abstract Serotonin
Eunseo Park, Hyunah Choo
wiley   +1 more source

Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair

Exploration, Volume 6, Issue 3, June 2026.
We developed a 3D bioprinted cardiac patch using bioinks containing morphology‐adjustable magnesium silicate nanoparticles, which release bioactive ions and modulate mechanical stiffness to activate myocardial energy metabolism. The nanoparticle morphology simultaneously enhances mitochondrial targeting and dynamic mechanical cues, boosting ATP ...
Zhibin Liao, Chen Qin, Erhong Song, Chengbin Ding, Zhixu Wang, Yan Sun, Chen Song, Junjie Liu, Jingge Ma, Hongjian Zhang, Leyu Wang, Chengtie Wu   +11 more
wiley   +1 more source

Histone deacetylase inhibition reduces cardiac Connexin43 expression and gap junction communication

Frontiers in Pharmacology, 2013
Histone deactylase (HDAC) inhibitors are being investigated as novel therapies for cancer, inflammation, neurodegeneration, and heart failure. The effects of HDAC inhibitors on the functional expression of cardiac gap junctions (GJ) are essentially ...
Qin eXu, Xianming eLin, Xianming eLin, Laura eAndrews, Dakshesh ePatel, Paul D Lampe, Richard David Veenstra   +6 more
doaj   +1 more source

Effects of Elevated Downstream Pressure and the Role of Smooth Muscle Cell Coupling through Connexin45 on Lymphatic Pacemaking

Biomolecules, 2020
Lymphatic vessels rely on spontaneous lymphatic muscle cell (LMC) contractions and one-way intraluminal valves to efficiently pump lymph and return it into the bloodstream. Intraluminal pressure is known to regulate the contractile function of lymphatics,
Jorge A. Castorena-Gonzalez, Min Li, Michael J. Davis   +2 more
doaj   +1 more source

Combined Inhibition of TRPM4/NMDA Receptor Complex and Extrasynaptic NMDA Receptors Is Candidate Therapeutic Target for Suppression of Epileptic Seizures and Improvement of Cognitive Impairments

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Cognitive impairments are important therapeutic targets in epilepsy medication; however, effective pharmacological treatments for epilepsy patients with comorbid cognitive impairment have not been established. Effects of chronic administration of MK‐801 (noncompetitive NMDA receptor inhibitor), memantine (low‐affinity extrasynaptic‐NMDA ...
Motohiro Okada, Ruri Okubo, Tomoka Oka, Eishi Motomura   +3 more
wiley   +1 more source

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu, Yosra Agban, Priyanka Agarwal, Avik Shome, Ilva D. Rupenthal, Heather Sheardown   +8 more
wiley   +1 more source

The effects of the Histone Deacetylase (HDAC) Inhibitor 4-Phenylbutyrate on gap junction conductance and permeability

Frontiers in Pharmacology, 2013
Longitudinal resistance is a key factor in determining cardiac action potential propagation. Action potential conduction velocity has been shown to be proportional to the square root of longitudinal resistance.
Joshua eKaufman, Chris eGordon, Roberto eBergamaschi, Hong Zhan Wang, Ira S Cohen, Virginijus eValiunas, Peter eBrink   +6 more
doaj   +1 more source