Results 51 to 60 of about 4,332 (134)

Cx43 upregulation in HUVECs under stretch via TGF-β1 and cytoskeletal network

Open Medicine, 2022
Many physiological and pathophysiological processes in cells or tissues are involved in mechanical stretch, which induces the gap junction gene expression and cytokine TGF beta changes.
Shi Yumeng, Li Xinbo, Yang Jin
doaj   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, Volume 13, Issue 23, 23 April 2026.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication

Brazilian Journal of Medical and Biological Research, 2000
Connexin43 (Cx43) is a major gap junction protein present in the Fischer-344 rat aorta. Previous studies have identified conditions under which selective disruption of intercellular communication with heptanol caused a significant, readily reversible and
G.J. Christ, P.R. Brink
doaj   +1 more source

Infection of 5xFAD mice with a mouse‐adapted SARS‐CoV‐2 does not alter Alzheimer's disease neuropathology yet induces widespread changes in gene expression across diverse cell types

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION The COVID‐19 pandemic underscored the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection on worsening the severity of Alzheimer's disease (AD) neuropathology and disease progression. METHODS Aged 5xFAD and wild‐type (WT) mice were infected with a mouse‐adapted SARS‐CoV‐2 (MA10), and extensive ...
Susana Furman, Latifa Zayou, Kate Inman Tsourmas, Dominic Ibarra Javonillo, Gema M. Olivarria, Yuting Cheng, Collin Pachow, Kellie Fernandez, Lucas Le, Robert A. Edwards, Dequina A. Nicholas, Gabriela Pacheco Sanchez, Ralph S. Baric, Kim N. Green, Thomas E. Lane   +14 more
wiley   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, Volume 4, Issue 1, March 2026.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

Simvastatin Attenuates Doxorubicin-Induced Inflammation in Human Cardiomyocytes

Biomedicines
Background/Objectives: Clinical application of Doxorubicin (Doxo) is limited by cardiotoxicity, a process strongly associated with an interplay between oxidative stress and inflammatory signaling, particularly Nuclear Factor kappa-light-chain-enhancer of
Roberta Vitale, Rosaria Margherita Rispoli, Maria Carmela Di Marcantonio, Barbara Pala, Stefania Marzocco, Gabriella Mincione, Ada Popolo   +6 more
doaj   +1 more source

SINO-ATRIAL NODE TELOCYTES IN THE HUMAN HEART. MORPHOLOGICAL EVIDENCE FOR PACEMAKING AND CONDUCTION PROPERTIES

Российский кардиологический журнал, 2017
The sinus node (SN) is built predominantly from pacemaking P-cells, transient T-cells, and Purkinje-like cells located on the periphery of the node. P-cells, especially in the center of SN, are surrounded by dense hardfiber fibrous tissue and do not ...
L. B. Mitrofanova, А. N. Gorshkov, P. V. Konovalov, Yu.  S. Krylova, V. О. Polyakova, I. М. Kvetnoy   +5 more
doaj   +1 more source

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development

Frontiers in Neuroscience, 2014
This study was conducted on human developing brain by laser confocal and transmission electron microscopy to make a detailed analysis of important features of blood-brain barrier microvessels and possible control mechanisms of vessel growth and ...
Mariella eErrede, Francesco eGirolamo, Marco eRizzi, Mirella eBertossi, Luisa eRoncali, Daniela eVirgintino   +5 more
doaj   +1 more source