Results 1 to 10 of about 14,914 (131)

GJA1-20k and Mitochondrial Dynamics

Frontiers in Physiology, 2022
Connexin 43 (Cx43) is the primary gap junction protein of mammalian heart ventricles and is encoded by the gene Gja1 which has a single coding exon and therefore cannot be spliced.
Robin Shaw, Daisuke Shimura
exaly   +3 more sources

GJA1/CX43 High Expression Levels in the Cervical Spinal Cord of ALS Patients Correlate to Microglia-Mediated Neuroinflammatory Profile

Biomedicines, 2022
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motoneurons (MNs) with a fatal outcome. The typical degeneration of cortico-spinal, spinal, and bulbar MNs, observed in post-mortem biopsies, is associated with the
Paola Castrogiovanni, Nunzio Vicario, Rosario Giuffrida   +2 more
exaly   +3 more sources

Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning

Frontiers in Physiology, 2022
Internal translation is a form of post-translation modification as it produces different proteins from one mRNA molecule by beginning translation at a methionine coding triplet downstream of the first methionine.
Robin Shaw
exaly   +3 more sources

Dnmt1 associated Gja1 promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury [PDF]

Epigenetics
DNA methylation has traditionally been regarded as a stable epigenetic modification. However, emerging evidence indicates that oxidative and genotoxic stress can induce locus-specific methylation changes that modulate transcriptional responses.
Yang Liu, Zijun Wang, Youxiao Zhao, Yanyan Ma, Jing Yi, Yingnan Song, Yanqiu Liu, Li An, Zhijun Pan, Hong Gao, Ying Cao   +10 more
doaj   +2 more sources

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels. [PDF]

Aging Cell
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Zhao D, Fu J, Liu H, Liang S, Song M, Zhang A, Wang DE, Guo Q, Zhang Y, Wu J, Xu H.   +10 more
europepmc   +2 more sources

Two novel GJA1 variants in oculodentodigital dysplasia

Molecular Genetics & Genomic Medicine, 2019
Background Oculodentodigital dysplasia (ODDD) is a rare disorder with pleiotropic effects involving multiple body systems, caused by mutations in the gap junction protein alpha 1 (GJA1) gene. GJA1 gene encodes a polytopic connexin membrane protein, Cx43,
Nikolai Paul Pace, David Agius, Isabella Borg   +2 more
exaly   +2 more sources

Ion channel gene signature for diagnosis and antifibrotic therapy in liver fibrosis [PDF]

Journal of Translational Medicine
Background Liver fibrosis (LF) is a progressive pathological process that may lead to cirrhosis and liver failure. Human ion channel genes (HICGs) participate in hepatic mechanotransduction and immune regulation, but their contributions to LF remain ...
Yun Li, Duoer Shen, Fusheng Qin, Dongkui Chen, Jianguo Li   +4 more
doaj   +2 more sources

Connexin 43 suppression enhances contractile force in human iPSC-derived cardiac tissues [PDF]

Frontiers in Bioengineering and Biotechnology
Connexin 43 (Cx43) plays a crucial role in maintaining synchronous contraction in the heart. However, it remains unclear whether Cx43 directly influences the contractile force and synchrony of entire cardiac tissues. Previously, we successfully developed
Takuma Takada, Takuma Takada, Katsuhisa Matsuura, Katsuhisa Matsuura, Katsuhisa Matsuura, Tatsuro Iida, Tatsuro Iida, Toshiharu Koike, Toshiharu Koike, Hidekazu Sekine, Yuhei Higashi, Yuhei Higashi, Tsukasa Hara, Daisuke Sasaki, Kyohei Fujita, Yuto Hinata, Yuto Hinata, Junichi Yamaguchi, Tatsuya Shimizu   +18 more
doaj   +2 more sources

GJA1-20k, a Short Isoform of Connexin43, from Its Discovery to Its Potential Implication in Cancer Progression

Cells
The Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Jonathan Clarhaut, Laurent Cronier, Arnaud Monvoisin   +2 more
exaly   +3 more sources

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base

eLife, 2022
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein α1 (GJA1) is the most commonly expressed subunit.
Dong Gil Jang, Keun Yeong Kwon, Yeong Cheon Kweon, Byung-gyu Kim, Kyungjae Myung, Hyun-Shik Lee, Chan Young Park, Taejoon Kwon, Tae Joo Park   +8 more
doaj   +1 more source