Results 1 to 10 of about 15,837 (117)

Connexin 43 enhances liver metastatic ability of GIST cells in vivo [PDF]

Pathology and Oncology Research
ObjectiveSmall intestinal gastrointestinal stromal tumors (SI-GISTs) have a higher risk of distant metastasis and recurrence than gastric GISTs (G-GISTs).
Takako Kihara, Jiayin Yuan, Takashi Yamasaki, Makoto Yoshida, Mizuka Ohkouchi, Yuka Nakaya-Hashikura, Neinei Kimura, Kanae Hyodo, Chisato Ohe, Seiichi Hirota   +9 more
doaj   +2 more sources

Nilotinib repositioning in cancers implying Cx43 tumorigenesis process [PDF]

World Cancer Research Journal, 2021
Objective: Among the 21 human connexins, the ubiquitous protein Cx43 is the most abundant in many cell types. It is also associated with the tumorigenic process and the formation of metastases in several types of common cancers such as breast and ...
S. Berrahoui, S. Cherrak, M. Saker, H. Merzouk, M. Dali-Sahi   +4 more
doaj   +1 more source

Connexin 43 confers chemoresistance through activating PI3K

Oncogenesis, 2022
Circumventing chemoresistance is crucial for effectively treating cancer including glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to chemotherapy; however, targeting Cx43 is difficult ...
Kevin J. Pridham, Farah Shah, Kasen R. Hutchings, Kevin L. Sheng, Sujuan Guo, Min Liu, Pratik Kanabur, Samy Lamouille, Gabrielle Lewis, Marc Morales, Jane Jourdan, Christina L. Grek, Gautam G. Ghatnekar, Robin Varghese, Deborah F. Kelly, Robert G. Gourdie, Zhi Sheng   +16 more
doaj   +1 more source

Loss of Cx43 in Murine Sertoli Cells Leads to Altered Prepubertal Sertoli Cell Maturation and Impairment of the Mitosis-Meiosis Switch

Cells, 2020
Male factor infertility is a problem in today’s society but many underlying causes are still unknown. The generation of a conditional Sertoli cell (SC)-specific connexin 43 (Cx43) knockout mouse line (SCCx43KO) has provided a translational model ...
Erika Hilbold, Ottmar Distl, Martina Hoedemaker, Sandra Wilkening, Rüdiger Behr, Aleksandar Rajkovic, Marion Langeheine, Kristina Rode, Klaus Jung, Julia Metzger, Ralph H. J. Brehm   +10 more
doaj   +1 more source

Uncoupling of the Astrocyte Syncytium Differentially Affects AQP4 Isoforms

Cells, 2020
The water channel protein aquaporin-4 (AQP4) and the gap junction forming proteins connexin-43 (Cx43) and connexin-30 (Cx30) are astrocytic proteins critically involved in brain water and ion homeostasis.
Shirin Katoozi, Nadia Skauli, Soulmaz Zahl, Tushar Deshpande, Pascal Ezan, Claudia Palazzo, Christian Steinhäuser, Antonio Frigeri, Martine Cohen-Salmon, Ole Petter Ottersen, Mahmood Amiry-Moghaddam   +10 more
doaj   +1 more source

miR-301-3p directly regulates to mediate the development of gastric cancer

Journal of International Medical Research, 2021
Objective Identifying novel biomarkers involved in the development of gastric cancer (GC) can provide potential therapeutic strategies and improve clinical prognosis. miR-301-3p and Cx43 are reportedly dysregulated in GC. miR-301-3p and Cx43 interaction,
Shasha Liu, Yang Zhao, Huan Liu, Xing Zhao, Xingbin Shen   +4 more
doaj   +1 more source

Cohesin mediates Esco2-dependent transcriptional regulation in a zebrafish regenerating fin model of Roberts Syndrome

Biology Open, 2017
Robert syndrome (RBS) and Cornelia de Lange syndrome (CdLS) are human developmental disorders characterized by craniofacial deformities, limb malformation and mental retardation.
Rajeswari Banerji, Robert V. Skibbens, M. Kathryn Iovine   +2 more
doaj   +1 more source

The expression of Cx43, TGFβ/smads signaling pathways and PCNA in the occurrence and development of gastric carcinoma and the relationship among them

Asian Journal of Medical Sciences, 2016
Aims and Objectives: To detect the protein expression level of Cx43, smad4 and PCNA in normal and gastric carcinoma tissue by immuno-histochemistry, western blotting and RT-PCR method.
Chun-Hui Li
doaj   +1 more source

Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation

Frontiers in Cell and Developmental Biology, 2022
Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming ...
Rui Hua, Sumin Gu, Jean X. Jiang
doaj   +1 more source

Detection and analysis of connexin in lesional skin from both mother and son with KID syndrome

Pifu-xingbing zhenliaoxue zazhi, 2019
Objective: To determine the expression levels of connexin Cx31, Cx43 and Cx50 in the lesional skin of KID syndrome and their roles in the pathogenesis of KID syndrome. Methods: Immunohistochemistry was used to determine the expression levels of connexins
Li-dan LIU, Ya-nan JIANG, Jia-rui LIU, Yong-feng CHEN   +3 more
doaj   +1 more source