Results 41 to 50 of about 21,433 (201)
Effects of Cd2+ on Cx43 expression in Cx43-LLC-PK1 cells.
, 2013 (A–C) Time- and dose-dependent effects of Cd2+ on Cx43 protein levels. Cx43-LLC-PK1 cells were treated with 35 μM CdCl2 for the indicated duration (A) or exposed to the indicated concentrations of CdCl2 for 6 h (C). The cellular protein was extracted and
Kun Gao (161056) +7 more
core +1 more source
Advanced Science, EarlyView.Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu +16 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundGuanylyl cyclase, a heme‐containing α1β1 heterodimer (GC1), produces cGMP in response to Nitric oxide (NO) stimulation. The NO‐GC1‐cGMP pathway negatively regulates cardiomyocyte contractility and protects against cardiac hypertrophy–related ...
Pierre‐Antoine Crassous +7 more
doaj +1 more source
Cx43 overexpression promotes SMC proliferation.
, 2015 hVSMC were infected or not (NI) with a control adenovirus (Ad-GFP) or a human Cx43 adenovirus (Ad-Cx43) at various multiplicity of infection (MOI) as indicated.
Florian Alonso (798974) +10 more
core +1 more source
Electrophysiology of single and aggregate Cx43 hemichannels. [PDF]
, 2012 Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals,
Carlo Montemagno (125840) +7 more
core +1 more source
Advanced Science, EarlyView.This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su +9 more
wiley +1 more source
Cx43 and mechanotransduction in bone
, 2015 Bone adaptation to changes in mechanical stimuli occurs by adjusting bone formation and resorption by osteoblasts and osteoclasts, to maintain optimal bone mass.
Donahue, Henry J. +2 more
core +1 more source
The Anatomical Record, EarlyView.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
wiley +1 more source
Cell & Bioscience, 2022 Background Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechanotransduction and anabolic ...
Yan Zeng +6 more
doaj +1 more source
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source