Results 61 to 70 of about 21,433 (201)
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced ScienceVentricular arrhythmias (VAs) as life‐threatening heart rhythm disorders, reduced connexin43 (Cx43) is one of the mechanisms of VAs. Cx43 is the predominant ventricular gap junction protein essential for cardiac electrical conduction; the absence in the ...
Hangying Ying +8 more
doaj +1 more source
Cyclic stretch increases Cx43 expression.
, 2014 HPAECs were grown to confluence on flexible Bioflex plates; subjected to pathological cyclic stretch (18% elongation), physiological cyclic stretch (5% elongation), or static stretch (0% elongation) for 24 hr.; and Cx43 protein or mRNA was measured.
Anna A. Birukova (333901) +3 more
core +1 more source
Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment
Med Research, EarlyView.An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu +9 more
wiley +1 more source
BiomoleculesThe transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has shown promise in preclinical models of myocardial infarction, but graft myocardium exhibits incomplete host–graft electromechanical integration and a propensity for ...
Rasha Al-attar +7 more
doaj +1 more source
Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms
Cell Reports, 2013 During each heartbeat, intercellular electrical coupling via connexin43 (Cx43) gap junctions enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces gap junction coupling, resulting in arrhythmias.
James W. Smyth, Robin M. Shaw
doaj +1 more source
International Journal of Oral Science, 2021 Dental pulp can initiate its damage repair after an injury of the pulp–dentin complex by rearrangement of odontoblasts and formation of newly differentiated odontoblast-like cells.
Jiaxin Yin +6 more
doaj +1 more source
Cell diameter and Cx43 protein expression.
, 2015 A, cell diameter measured using caveolin 3 immunostaining (green signal). Graph shows diameter for cells of the atrial septum, His bundle and ventricular septum (means±SEM, n = 5/6; 2-way ANOVA ...
Andrew J. Atkinson (819204) +13 more
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT The Nav1.5 channel, a major isoform of voltage‐gated sodium ion channel, is mainly found in ventricular cardiomyocytes, playing a key role in generating essential cardiac action potentials for normal heart rhythms. Mutations in Nav1.5 have been associated with severe heart conditions such as long QT syndrome, Brugada syndrome, cardiac ...
Arkapravo Chattopadhyay +3 more
wiley +1 more source
Connexin43 and Bergmann glial gap junctions in cerebellar function
Frontiers in Neuroscience, 2008 Connexin43 (Cx43), a major component of astrocytic gap junctions, is abundantly expressed in Bergmann glial cells (BGCs) in the cerebellum, but the function of Cx43 in BGCs is largely unknown.
Mika Tanaka +6 more
doaj +1 more source
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source