Results 51 to 60 of about 21,433 (201)
Frontiers in Cell and Developmental Biology, 2022 Adipose tissue macrophages are a major immune cell type contributing to homeostatic maintenance and pathological adipose tissue remodeling. However, the mechanisms underlying macrophage recruitment and polarization in adipose tissue during obesity remain
Cheoljun Choi +6 more
doaj +1 more source
The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity
Epilepsia Open, EarlyView.Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia +4 more
wiley +1 more source
Confirmation of Cx43 deletion by PCR.
, 2013 The figure shows PCR of genomic DNA extracted from bladder (bld), brain (brn), calvaria (cal), heart (ht), humerus (hm), intestine (int), liver (lv), muscle (msl), skin (sk), and spleen (spl) from a OC-Cre; Cx43flx/+ mouse.
Vikram Sathyendra (345239) +8 more
core +1 more source
Heliyon, 2023 Background: Connexin 43 (Cx43) has been closely linked to the occurrence and progression of breast cancer. Distant metastasis of breast cancer is aided by the epithelial-mesenchymal transition of circulating tumor cells (CTCs).
Dan-Qing Wang +6 more
doaj +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Chlorfenapyr (CHL) is a widely used pyrrole insecticide, but its hepatotoxic effects and underlying mechanisms remain incompletely understood. This study investigated the toxic effects of CHL on rat liver and BRL‐3A hepatocytes and explored the involvement of the Keap1/Nrf2 signaling pathway. Rats were administered CHL (10, 20, or 30 mg/kg) by
Dongquan Zhao +4 more
wiley +1 more source
European Journal of Histochemistry, 2015 The expression pattern of connexin 43 (Cx43) in the cochlea is not determined and is controversial. Since the presence of Cx43 is essential for hearing, we re-examined its distribution during postnatal development of rat cochlea.
W.J. Liu, J. Yang
doaj +1 more source
Cardiovascular Therapeutics, 2020 Several studies have indicated that long noncoding RNAs (lncRNAs)-HOX transcript antisense RNA (HOTAIR) is involved in some cardiovascular diseases by regulating gene expression as a competitive endogenous RNA (ceRNA). GJA1 encoding Cx43 is one potential
Weiran Dai +5 more
doaj +1 more source
Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. [PDF]
PLoS ONE, 2016 Gap junctions are membrane specialization domains identified in most tissue types where cells abut each other. The connexin channels found in these membrane domains are conduits for direct cell-to-cell transfer of ions and molecules. Connexin43 (Cx43) is
Cinzia Ambrosi +7 more
doaj +1 more source
BAK treatment increased Cx43 phosphorylation status.
, 2014 Exposure to BAK induced the increase of phosphorylated Cx43 (A). In 0.05% and 0.1%BAK group, P-Cx43 increased significantly compared with control cornea. Quantitative analysis of P-Cx43 abundance was shown in (B).
Juxin Pan (535992) +8 more
core +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati +6 more
wiley +1 more source