Results 21 to 30 of about 21,433 (201)

Generation and Characterization of an Inducible Cx43 Overexpression System in Mouse Embryonic Stem Cells

Cells, 2022
Connexins (Cx) are a large family of membrane proteins that can form intercellular connections, so-called gap junctions between adjacent cells. Cx43 is widely expressed in mammals and has a variety of different functions, such as the propagation of ...
Pia Niemann, Miriam Schiffer, Daniela Malan, Sabine Grünberg, Wilhelm Roell, Caroline Geisen, Bernd K. Fleischmann   +6 more
doaj   +1 more source

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

Frontiers in Physiology, 2014
Intercellular communication in primary bovine corneal endothelial cells (BCECs) is mainly driven by the release of extracellular ATP through Cx43 hemichannels.
Catheleyne eD'hondt, Jegan eIyyathurai, Bernard eHimpens, Luc eLeybaert, Geert eBultynck   +4 more
doaj   +1 more source

Breakthrough Cancer Pain Is Associated with Spinal Gap Junction Activation via Regulation of Connexin 43 in a Mouse Model

Frontiers in Cellular Neuroscience, 2017
Breakthrough cancer pain (BTcP) is a high-intensity, short-duration, unpredictable and uncontrollable pain. Recent studies have shown that activation of gap junction (GJ) in spinal cord plays an important role in the pathogenesis of BTcP. We examined the
Xin Li, Siqing Jiang, Hui Yang, Qian Liao, Shousong Cao, Xuebin Yan, Dong Huang   +6 more
doaj   +1 more source

MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

Molecular Brain, 2023
Necroptosis is known to play an important role in the pathophysiology of cerebral ischemia; however, its role in the occurrence of secondary thalamic injury after focal cerebral infarction and the mechanism about how mixed lineage kinase domain-like ...
Yanyan Tang, Quanhong Chu, Guanfeng Xie, Yafu Tan, Ziming Ye, Chao Qin   +5 more
doaj   +1 more source

Heterotypic Docking of Cx43 and Cx45 Connexons Blocks Fast Voltage Gating of Cx43 [PDF]

, 2001
Immunohistochemical co-localization of distinct connexins (Cxs) in junctional areas suggests the formation of heteromultimeric channels. To determine the docking effects of the heterotypic combination of Cx43 and Cx45 on the voltage-gating properties of ...
Martinez, Agustin D., Moreno, Alonso P., Beyer, Eric C., Elenes, Sergio, Delmar, Mario   +4 more
core   +1 more source

Interactive mechanism between connexin43 and Cd-induced autophagic flux blockage and gap junctional intercellular communication dysfunction in rat hepatocytes

Heliyon, 2023
Cadmium (Cd) is a significant environmental contaminant known for its potential hepatotoxic effects. However, the precise mechanisms underlying Cd-induced hepatotoxicity have yet to be fully understood.
Yuntian Duan, Yi Zhang, Tao Wang, Jian Sun, Waseem Ali, Yonggang Ma, Yan Yuan, Jianhong Gu, Jianchun Bian, Zongping Liu, Hui Zou   +10 more
doaj   +1 more source

MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation

, 2012
<p>Rationale: Dedifferentiation of vascular smooth muscle cells (VSMC) leading to a proliferative cell phenotype significantly contributes to the development of atherosclerosis.
Columbus, L., Koval, M., Johnstone, S.R., Kroncke, B.M., Isakson, B.E., Dunn, C.A., Nakamoto, R.K., Straub, A.C., Best, A.K., Lampe, P.D., Lo, C.W., Peskova, Y., Mitchell, L.A.   +12 more
core   +1 more source

Cx43-CT^234-382Y265D mutation inhibits the interaction with Drb^1-300 by NMR.

, 2016
(A) 15N-HSQC spectrum of Cx43-CT234-382Y265D alone (black) has been overlaid with the spectrum obtained in the presence of the Drb1-300 construct at a 1:14 ratio (red).
Cynthia Ren (2826683), Elena E. Grintsevich (2233096), Gaelle Spagnol (2826692), Cinzia Ambrosi (446348), Angela Cone (2826686), Gina E. Sosinsky (446355), Gabriel Cavin (2826689), Paul L. Sorgen (2826680)   +7 more
core   +1 more source

Aerobic exercise increases connexin43 expression in rat cardiac muscle [PDF]

Universa Medicina, 2013
Background Intercellular communication in cardiac muscle is effected by connexin, particularly connexin43 (Cx43), forming gap junctions in cardiomyocytes. Aerobic physical exercise may result in increased left ventricular size and function. The purpose
Fransisca Chondro, Minarma Siagian, Dewi IS Santoso   +2 more
doaj  

Brain gray matter astroglia-specific connexin 43 ablation attenuates spinal cord inflammatory demyelination

Journal of Neuroinflammation, 2021
Background Brain astroglia are activated preceding the onset of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
Hayato Une, Ryo Yamasaki, Satoshi Nagata, Hiroo Yamaguchi, Yuko Nakamuta, Ulfa Camelia Indiasari, Yiwen Cui, Koji Shinoda, Katsuhisa Masaki, Magdalena Götz, Jun-ichi Kira   +10 more
doaj   +1 more source