Results 11 to 20 of about 21,433 (201)

Opposite Effects of Moderate and Extreme Cx43 Deficiency in Conditional Cx43-Deficient Mice on Angiotensin II-Induced Cardiac Fibrosis [PDF]

Cells, 2019
Connexin 43 (Cx43) is essential for cardiac electrical coupling, but its effects on myocardial fibrosis is controversial. Here, we analyzed the role of Cx43 in myocardial fibrosis caused by angiotensin II (AngII) using Cx43fl/fl and Cx43Cre-ER(T)/fl ...
Laura Valls-Lacalle, Corall Negre-Pujol, Cristina Rodríguez, Saray Varona, Antoni Valera-Cañellas, Marta Consegal, Jose Martínez-González, Antonio Rodríguez-Sinovas   +7 more
doaj   +2 more sources

Mutations of the Cx43 Gene in Non-Small Cell Lung Cancer: Association with Aberrant Localization of Cx43 Protein Expression and Tumor Progression

Medicina
Background and Objectives: The Connexin43 (Cx43) gene is a suspected tumor suppressor gene, as re-expressed wild-type Cx43 genes reduce the malignancy potential of tumor cells. However, the role of Cx43 gene expression in human lung tumorigenesis remains
Jung-Chien Chen, Kun-Tu Yeh, Yueh-Min Lin, Ya-Wen Cheng   +3 more
doaj   +2 more sources

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex. [PDF]

Glia
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Lewis RW, Dogan BC, Stanek AL, Evans EB, Coble MG, Spence-Osorio HE, Farizatto KLG, Mordant AL, Mills CA, Herring LE, Baldwin KT.   +10 more
europepmc   +2 more sources

Piezo1 Activation Rescues Anabolic Response to Mechanical Loading in Aged Bone via Connexin 43 Hemichannels. [PDF]

Aging Cell
Yoda1‐induced Piezo1 activation enhances Piezo1‐Cx43 interaction upon mechanical stimulation, triggering PI3K‐Akt signaling to drive Cx43 phosphorylation and hemichannel opening. These events elevate PGE2 release, suppress SOST expression in senescent osteocytes, and ultimately enhance bone anabolism on the endosteal surface.
Zhao D, Fu J, Liu H, Liang S, Song M, Zhang A, Wang DE, Guo Q, Zhang Y, Wu J, Xu H.   +10 more
europepmc   +2 more sources

Immunoglobulin Kappa Light Chain Produced by Cardiomyocytes and Participates in Maintaining Intercalated Disc Integrity. [PDF]

MedComm (2020)
This study identifies Igκ expression in cardiomyocytes, with predominant localization at ICDs. Cardiomyocyte‐specific Igκ knockout induces cardiac dysfunction and ICDs structural disorganization. Mechanistically, Igκ stabilizes plectin to facilitate desmin‒actin network assembly and anchor desmin to DSP, which is critical for maintaining ICDs ...
Zhu Z, Sheng Y, Chang Y, Chang Y, Xu M, Zhou W, Wang W, Liao Q, Shi Z, Zhang M, Lan F, Song J, Qiu X.   +12 more
europepmc   +2 more sources

Changes in connexin 43 in inflammatory skin disorders: Eczema, psoriasis, and Steven‐Johnson syndrome/toxic epidermal necrolysis

Health Science Reports, 2021
Background Connexin 43 (Cx43) plays a central role in the inflammatory response and wound healing. Targeting Cx43 expression reduces inflammation in a variety of injuries.
Mandy L. L. Tan, Hui L. Kwong, Chia C. Ang, Hong L. Tey, Joyce S. S. Lee, David L. Becker   +5 more
doaj   +1 more source

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells [PDF]

, 2015
Intercellular communication is vital to ensure tissue and organism homeostasis and can occur directly, between neighbour cells via gap junctions (GJ), or indirectly, at longer distances, through extracellular vesicles, including exosomes.
Manadas, Bruno, Girao, Henrique, Ribeiro-Rodrigues, Teresa, Anjo, Sandra Isabel, Catarino, Steve, Pereira, Paulo, Martins-Marques, Tania, Pinho, Maria Joao, Ferreira, Joao Vasco, Sluijter, Joost P.G., Sluijter, Joost P G, Sluijter, Joost P. G., Soares, Ana Rosa, Zuzarte, Monica   +13 more
core   +2 more sources

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Open Biology, 2023
Classically associated with gap junction-mediated intercellular communication, connexin43 (Cx43) is increasingly recognized to possess non-canonical biological functions, including gene expression regulation.
Tania Martins-Marques, Katja Witschas, Ilda Ribeiro, Mónica Zuzarte, Steve Catarino, Teresa Ribeiro-Rodrigues, Francisco Caramelo, Trond Aasen, Isabel Marques Carreira, Lino Goncalves, Luc Leybaert, Henrique Girao   +11 more
doaj   +1 more source

Connexin43 hemichannel-mediated regulation of connexin43. [PDF]

PLoS ONE, 2013
BACKGROUND: Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs.
Kai Li, Yuan Chi, Kun Gao, Qiaojing Yan, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura, Jian Yao   +7 more
doaj   +1 more source

Importance of Cx43 for Right Ventricular Function

, 2021
In the heart, connexins form gap junctions, hemichannels, and are also present within mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles.
Norbert Weissmann, Kerstin Boengler, Susanne Rohrbach, Rainer Schulz   +3 more
core   +1 more source