Results 41 to 50 of about 15,686 (159)

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Effects of prostaglandin E2 on gap junction protein alpha 1 (GJA1) in the rat epididymis

, 2018
Gap junctions are responsible for intercellular communication. In the adult mammalian epididymis, gap junction protein alpha 1 (GJA1) is localized between basal and either principal or clear cells.
Gregory, Mary, Cyr, Daniel G., Cyr, Daniel   +2 more
core   +1 more source

Two de novo GJA1 mutation in two sporadic patients with erythrokeratodermia variabilis et progressiva

Molecular Genetics & Genomic Medicine, 2019
Background Erythrokeratodermia variabilis et progressiva (EKVP, OMIM 133200) is a rare hereditary disorder characterized by varies from transient, fast moving erythema to persistent brown hyperkeratotic plaques.
Changxing Li, Jingyao Liang, Pingjiao Chen, Kang Zeng, Rujun Xue, Xin Tian, Liuping Liang, Qi Wang, Minglan Shi, Xibao Zhang   +9 more
doaj   +1 more source

The genetic architecture of epilepsy across molecular mechanisms and clinical heterogeneity

Epilepsia Open, EarlyView.
Abstract Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by remarkably diverse genetic, molecular, and network‐level mechanisms. Advances in genomic technologies have revealed that epilepsy arises from a multilayered genetic architecture encompassing rare
Mohammad Reza Seyedtaghia, Jina Babanzadeh, Marcello Scala, Lorenzo Perilli, Pasquale Striano   +4 more
wiley   +1 more source

Cx43 (GJA1) expression and phosphorylation pattern in patients with TOF or DORV of Fallot-type.

, 2014
A: Cx43 (GJA1) protein and mRNA expression All values of Cx43 (GJA1) protein and mRNA are given as means±SEM.
Aida Salameh (584203), Ingo Dähnert (584212), Stefan Dhein (584211), Paul Bräuchle (584205), Marko Reitmann (584208), Oliver Peim (584206), Thomas Seidel (584207), Josphina Haunschild (584204), Martin Kostelka (584209), Farhad Bakhtiary (584210)   +9 more
core   +1 more source

Significance of connexion genes in non-syndromic deafness in Africans [PDF]

, 2013
Includes abstract.
Bosch, Jason
core   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Additional file 1: of GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

, 2018
Tables S1. Clinical and pathological traits, brain regions analyzed by transcriptome profiling, and sample classification with respect to the severity stage of each trait. Table S2. Correlations between GJA1 expression and individual phenotypical traits.
Minghui Wang (15418), Erming Wang (110480), Joseph Buxbaum (3464495), Yuji Kajiwara (265261), Wun Sin (6113147), Christian Naus (6113159), Bin Zhang (64682), Eric Schadt (105785), Kristen J. Brennand (6113150)   +8 more
core   +1 more source

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

The Potential Role of GJA1 and SPP1 Expressed by the Endometrium Based on Single Cell Transcriptome Analysis in Endometrial Infertility

Clinical and Experimental Obstetrics & Gynecology
Background: Endometrial infertility accounts for a significant proportion of infertility cases, and single-cell transcriptome data have revealed that hub genes may play an important role during pregnancy.
Zhenzhen Lu, Qianqian Tang, Chunyan Chen, Xiaojie Zhao, Ying Gao, Qiongqiong Wei   +5 more
doaj   +1 more source