Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport [PDF]
Frontiers in Physiology, 2017 Connexin 43 (Cx43, encoded by GJA1) is a cell-cell communication gap junction protein expressed in all organ systems. It was recently found that GJA1 mRNA undergoes alternative translation to generate N-terminal truncated isoforms, of which GJA1-20k is ...
Robin Shaw +2 more
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GJA1-20k, a Short Isoform of Connexin43, from Its Discovery to Its Potential Implication in Cancer Progression [PDF]
CellsThe Connexin43 transmembrane protein (Cx43), encoded by the GJA1 gene, is a member of a multigenic family of proteins that oligomerize to form hemichannels and intercellular channels, allowing gap junctional intercellular communication between adjacent ...
Jonathan Clarhaut +2 more
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Protective mitochondrial fission induced by stress-responsive protein GJA1-20k [PDF]
eLife, 2021 The Connexin43 gap junction gene GJA1 has one coding exon, but its mRNA undergoes internal translation to generate N-terminal truncated isoforms of Connexin43 with the predominant isoform being only 20 kDa in size (GJA1-20k).
Daisuke Shimura +9 more
doaj +4 more sources
GJA1-20k and Mitochondrial Dynamics [PDF]
Frontiers in Physiology, 2022 Connexin 43 (Cx43) is the primary gap junction protein of mammalian heart ventricles and is encoded by the gene Gja1 which has a single coding exon and therefore cannot be spliced.
Robin Shaw, Daisuke Shimura
exaly +4 more sources
Internal translation of Gja1 (Connexin43) to produce GJA1-20k: Implications for arrhythmia and ischemic-preconditioning [PDF]
Frontiers in Physiology, 2022 Internal translation is a form of post-translation modification as it produces different proteins from one mRNA molecule by beginning translation at a methionine coding triplet downstream of the first methionine.
Robin Shaw
exaly +4 more sources
Connexin 43 regulates intercellular mitochondrial transfer from human mesenchymal stromal cells to chondrocytes [PDF]
Stem Cell Research & TherapyBackground The phenomenon of intercellular mitochondrial transfer from mesenchymal stromal cells (MSCs) has shown promise for improving tissue healing after injury and has potential for treating degenerative diseases like osteoarthritis (OA).
Rebecca M. Irwin +5 more
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Exploring the Potent Roles of an Internally Translated Truncated Connexin-43 Isoform [PDF]
BiologyConnexins are a family of transmembrane proteins that form membrane channels [...]
Robin Shaw
exaly +4 more sources
Connexin 43 in Mitochondria: What Do We Really Know About Its Function? [PDF]
Frontiers in Physiology, 2022 Connexins are known for their ability to mediate cell-cell communication via gap junctions and also form hemichannels that pass ions and molecules over the plasma membrane when open.
Kerstin Boengler +3 more
doaj +2 more sources
Gap Junction-Dependent and -Independent Functions of Connexin43 in Biology [PDF]
Biology, 2022 For the first time in animal evolution, the emergence of gap junctions allowed direct exchanges of cellular substances for communication between two cells.
Yi Zhu
doaj +2 more sources
Connexin 43 Role in Mitochondrial Transfer and Homeostasis in the Central Nervous System. [PDF]
J Cell PhysiolABSTRACT Connexin 43 (Cx43) is a transmembrane protein involved in the assembly of gap junctions (GJs) and hemichannels (HCs), organized structures that allow the transferring of ions and small signaling molecules between cells and/or extracellular environment, thereby contributing to tissue homeostasis intercellular communication.
Gervasi A +5 more
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