Results 21 to 30 of about 5,181 (103)
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base [PDF]
, 2022 The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction protein ??1 (GJA1) is the most commonly expressed subunit. A recent study showed that GJA1 is necessary for the maintenance of motile
Park, Tae Joo +18 more
core +1 more source
The DarkSide-20k TPC and underground argon cryogenic system
, 2023 DarkSide-20k (DS-20k) will exploit the physical and chemical properties of liquid argon (LAr) housed within a large dual-phase time project chamber (TPC) in its direct search for dark matter.
Thomas N. Thorpe on behalf of the DS-20k collaboration
core +1 more source
Mitochondrial ion channels as targets for cardioprotection
Journal of Cellular and Molecular Medicine, Volume 24, Issue 13, Page 7102-7114, July 2020., 2020 Abstract Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular ...
Derek J. Hausenloy +7 more
wiley +1 more source
The simulation of the DarkSide-20k calibration
, 2023 International audienceDarkSide-20k will be the next liquid argon TPC built to perform direct search for dark matter under the form of WIMPs. Its calibration to both signal and backgrounds is key as very few events are expected in WIMPs search.
van Uffelen, Marie
core +2 more sources
Cell Reports, 2019 Summary: Connexin43 (Cx43; gene name GJA1) is the most ubiquitously expressed gap junction protein, and understanding of its regulation largely falls under transcription and post-translational modification.
Michael J. Zeitz +7 more
doaj +1 more source
, 2023 Familial cerebral cavernous malformation type III (fCCM3) is a cerebrovascular disease associated with loss-of-function mutations in programmed cell death 10 (PDCD10/CCM3).
Phillips, Chelsea
core +1 more source
PLAS-20k: Extended Dataset of Protein-Ligand Affinities from MD Simulations for Machine Learning Applications [PDF]
, 2023 Computing binding affinities is of great importance in drug discovery pipeline and its prediction using advanced machine learning methods still remains a major challenge as the existing datasets and models do not consider the dynamic features of protein ...
Vishal , Kumar +17 more
core +2 more sources
Measurement of isotopic separation of argon with the prototype of the cryogenic distillation plant Aria for dark matter searches [PDF]
, 2023 The Aria cryogenic distillation plant, located in Sardinia, Italy, is a key component of the DarkSide-20k experimental program for WIMP dark matter searches at the INFN Laboratori Nazionali del Gran Sasso, Italy.
Collaboration, The DarkSide-20k
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Expression patterns of Phf5a/PHF5A and Gja1/GJA1 in rat and human endometrial cancer [PDF]
, 2013 Endometrial adenocarcinoma is the most frequently diagnosed cancer of the female genital tract in the western world. Studies of complex diseases can be difficult to perform on human tumor samples due to the high genetic heterogeneity in human. The use of
Eva Falck +4 more
core +1 more source
, 2018 Epithelial–mesenchymal transition (EMT) is activated during development, wound healing, and pathologies including fibrosis and cancer metastasis. Hallmarks of EMT are remodeling of intercellular junctions and adhesion proteins, including gap junctions ...
Patrick J. Calhoun +9 more
core +1 more source