GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs [PDF]
Circulation Research, 2017 Rationale: Delivery of Cx43 (connexin 43) to the intercalated disc is a continuous and rapid process critical for intercellular coupling.
Robin Shaw +2 more
exaly +3 more sources
Astrocyte-derived exosome-transported GJA1-20k attenuates traumatic brain injury in rats [PDF]
Chinese Medical Journal, 2023 Jiugeng Feng +9 more
doaj +2 more sources
Mitochondrial Quality Control in Health and Disease. [PDF]
MedComm (2020)Mitochondrial quality control (MQC) maintains cellular homeostasis by coordinating various processes such as fission, fusion, mitophagy, and mitochondria‐regulated cell death. Dysregulation of these mechanisms plays a key role in the development of many human diseases.
Ye L, Fu X, Li Q.
europepmc +2 more sources
GJA1-20k Rescues Cx43 Localization and Arrhythmias in Arrhythmogenic Cardiomyopathy [PDF]
Circulation Research, 2023 Robin Shaw +2 more
exaly +2 more sources
Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias [PDF]
Journal of Clinical Investigation, 2020 Robin Shaw +2 more
exaly +2 more sources
Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury [PDF]
JCI Insight, 2018 Robin Shaw +2 more
exaly +2 more sources
Left Ventricular Unloading With Assist Device Implantation Increases GJA1-20k Expression in Patients With Arrhythmogenic Cardiomyopathy [PDF]
Circulation: Heart FailureRobin Shaw +2 more
exaly +2 more sources
Mitochondria: At the crossroads between mechanobiology and cell metabolism
Biology of the Cell, Volume 115, Issue 9, September 2023., 2023 The organization and morphology of the mitochondrial network reflect the bioenergetic functions of tissues and cells. Reciprocally, energy needs impact mitochondrial morphodynamics. External and internal mechanical forces can alter mitochondrial morphodynamics, under the control of key regulators such as membrane curvature and tension.
Émilie Su +2 more
wiley +1 more source
Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021 Gap junctions are the main form of interaction between cardiomyocytes, through which the electrochemical activities between cardiomyocytes can be synchronized to maintain the normal function of the heart. Connexins are the basis of gap junctions.
Keke Liu +8 more
wiley +1 more source
Study of cosmogenic activation above ground for the DarkSide-20k experiment [PDF]
, 2023 The activation of materials due to exposure to cosmic rays may become an important background source for experiments investigating rare event phenomena.
Collaboration, DarkSide-20k
core +1 more source