Results 31 to 40 of about 15,686 (159)

Milk-derived small extracellular vesicles: nanomaterials to promote bone formation

Journal of Nanobiotechnology, 2022
Small extracellular vesicles (sEVs) are an important component in the paracrine pathway. They can be used as a substitute for seed cells and have shown good application prospects in promoting bone regeneration.
Ming Dong, Chun Shi, Xinxin Yu, Qian Yang, Saixuan Wu, Runyuan Liu, Tingjiao Liu, Lina Wang, Weidong Niu   +8 more
doaj   +1 more source

Dynamic UTR Usage Regulates Alternative Translation to Modulate Gap Junction Formation during Stress and Aging

Cell Reports, 2019
Summary: Connexin43 (Cx43; gene name GJA1) is the most ubiquitously expressed gap junction protein, and understanding of its regulation largely falls under transcription and post-translational modification.
Michael J. Zeitz, Patrick J. Calhoun, Carissa C. James, Thomas Taetzsch, Kijana K. George, Stefanie Robel, Gregorio Valdez, James W. Smyth   +7 more
doaj   +1 more source

Identification of Potential Driver Genes and Pathways Based on Transcriptomics Data in Alzheimer's Disease

Frontiers in Aging Neuroscience, 2022
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. To identify AD-related genes from transcriptomics and help to develop new drugs to treat AD.
Liang-Yong Xia, Lihong Tang, Hui Huang, Jie Luo   +3 more
doaj   +1 more source

Nanotherapy for bone repair: milk-derived small extracellular vesicles delivery of icariin

Drug Delivery, 2023
Icariin (ICA) played an important role in the treatment of inflammatory bone defects. However, pharmacokinetic studies have shown that its poor bioavailability limited its application. In this context, we isolated bovine milk-derived sEV and prepared sEV-
Xinxin Yu, Ming Dong, Lina Wang, Qian Yang, Long Wang, Wenqing Han, Juhong Dong, Tingjiao Liu, Ying Kong, Weidong Niu   +9 more
doaj   +1 more source

GJA1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Colorectal Cancer

Cancer Management and Research, 2020
Wenjun Hu,1,2,* Shuchun Li,1,2,* Sen Zhang,1,2 Bowen Xie,1 Minhua Zheng,1,2 Jing Sun,1,2 Xiao Yang,1,2 Lu Zang1,2 1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ...
Hu W, Li S, Zhang S, Xie B, Zheng M, Sun J, Yang X, Zang L   +7 more
doaj  

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Additional file 2: of GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

, 2018
Figure S1. Correlations between GIA1 and individual clinic traits stratified by AOD (age of death), gender and APOE genotypes in BM36 region. Figure S2. Correlation between Gja1 and individual transcripts of ADGWAS genes. Figure S3. GJA1-centric Bayesian
Minghui Wang (15418), Erming Wang (110480), Joseph Buxbaum (3464495), Yuji Kajiwara (265261), Wun Sin (6113147), Christian Naus (6113159), Bin Zhang (64682), Eric Schadt (105785), Kristen J. Brennand (6113150)   +8 more
core   +1 more source

Role of soft tissue and bone interactions in the developmental integration and modularity of the skull in neural crest‐specific gap junction alpha‐1 knockout mice

The Anatomical Record, EarlyView.
Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore, Madeline Tourigny, Diana Quinonez, Kevin Barr, Matthew W. Grol, Katherine E. Willmore   +5 more
wiley   +1 more source

Gja1 acts downstream of Acvr1 to regulate uterine decidualization via Hand2 in mice

, 2017
Although Gja1 has been proved to play an important role in uterine decidualization, its regulatory mechanism remains largely unknown. Here, we showed that Gja1 was highly expressed in the decidual cells and promoted the proliferation of uterine stromal ...
Hai-Fan Yu, Hong-Liang Zhang, Zhan-Peng Yue, Shuang Geng, Kai Wang, Bin Guo, Zhan-Qing Yang   +6 more
core   +1 more source

Évaluation du rôle et de la régulation de GJA1 (Connexine 43) dans les glandes mammaires et le cancer du sein [PDF]

, 2018
Le cancer du sein est le cancer le plus fréquent chez les femmes, comptant pour 25% des cancers féminins et affectant ainsi une femme sur huit, et le plus mortel, faisant plus de 500 000 victimes par année dans le monde.
Busby, Mélanie
core   +2 more sources