Results 11 to 20 of about 15,686 (159)

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

Acta Neuropathologica Communications, 2018
GJA1 (connexin43) has been predicted as the top key driver of an astrocyte enriched subnetwork associated with Alzheimer’s disease (AD). In this study, we comprehensively examined GJA1 expression across 29 transcriptomic and proteomic datasets from post ...
Yuji Kajiwara, Erming Wang, Minghui Wang, Wun Chey Sin, Kristen J. Brennand, Eric Schadt, Christian C. Naus, Joseph Buxbaum, Bin Zhang   +8 more
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Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport

Frontiers in Physiology, 2017
Connexin 43 (Cx43, encoded by GJA1) is a cell-cell communication gap junction protein expressed in all organ systems. It was recently found that GJA1 mRNA undergoes alternative translation to generate N-terminal truncated isoforms, of which GJA1-20k is ...
Ying Fu, Shan-Shan Zhang, Shaohua Xiao, Wassim A. Basheer, Rachel Baum, Irina Epifantseva, TingTing Hong, TingTing Hong, Robin M. Shaw, Robin M. Shaw   +9 more
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On the role of the gap junction protein Cx43 (GJA1) in human cardiac malformations with Fallot-pathology. a study on paediatric cardiac specimen. [PDF]

PLoS ONE, 2014
INTRODUCTION: Gap junction channels are involved in growth and differentiation. Therefore, we wanted to elucidate if the main cardiac gap junction protein connexin43 (GJA1) is altered in patients with Tetralogy of Fallot or double-outlet right ventricle ...
Aida Salameh, Josphina Haunschild, Paul Bräuchle, Oliver Peim, Thomas Seidel, Marko Reitmann, Martin Kostelka, Farhad Bakhtiary, Stefan Dhein, Ingo Dähnert   +9 more
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Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells

Cardiovascular Therapeutics, 2022
Background. Deep vein thrombosis (DVT) is the third most prevalent vascular disease worldwide. MicroRNAs (miRNAs) play regulatory roles in functions of endothelial progenitor cells (EPCs), which is becoming a promising therapeutic choice for thrombus ...
Yan Li, Jingping Ge, Yuanyuan Yin, Ruowen Yang, Jie Kong, Jianping Gu   +5 more
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Members of the AP-1 Family of Transcription Factors Regulate the Expression of Gja1 in Mouse GC-1 Spermatogonial Cells

Applied Sciences, 2022
Gap junctions, mainly formed by Gja1 (Connexin43), play an essential role in the regulation of proliferation and differentiation of spermatogonia in the testis.
Mustapha Najih, Audrey Basque, Ha Tuyen Nguyen, Mariama Diawara, Luc J. Martin   +4 more
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Heterozygous deletion of both sclerostin (Sost) and connexin43 (Gja1) genes in mice is not sufficient to impair cortical bone modeling. [PDF]

PLoS ONE, 2017
Connexin43 (Cx43) is the main gap junction protein expressed in bone forming cells, where it modulates peak bone mass acquisition and cortical modeling.
Susan K Grimston, Francesca Fontana, Marcus Watkins, Roberto Civitelli   +3 more
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GJA1 Expression and Left Atrial Remodeling in the Incidence of Atrial Fibrillation in Patients with Obstructive Sleep Apnea Syndrome

Biomedicines, 2021
Obstructive sleep apnea syndrome (OSAS) is an important risk factor for atrial fibrillation (AF). GJA1 gene encoding connexin43, a major protein in cardiac gap junctions, plays a crucial role in the synchronized contraction of the heart and in cardiac ...
Yung-Lung Chen, Yung-Che Chen, Ya-Ting Chang, Hui-Ting Wang, Wen-Hao Liu, Shaur-Zheng Chong, Pei-Ting Lin, Po-Yuan Hsu, Mao-Chang Su, Meng-Chih Lin   +9 more
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An Alternatively Translated Connexin 43 Isoform, GJA1-11k, Localizes to the Nucleus and Can Inhibit Cell Cycle Progression

Biomolecules, 2020
Connexin 43 (Cx43) is a gap junction protein that assembles at the cell border to form intercellular gap junction (GJ) channels which allow for cell−cell communication by facilitating the rapid transmission of ions and other small molecules between
Irina Epifantseva, Shaohua Xiao, Rachel E. Baum, André G. Kléber, TingTing Hong, Robin M. Shaw   +5 more
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Rare mosaic variant of GJA1 in a patient with a neurodevelopmental disorder

Human Genome Variation
GJA1 is the causative gene for oculodentodigital dysplasia (ODDD). A novel de novo GJA1 variant, NM 000165:c263C > T [p.P88L], was identified in a mosaic state in a patient with short stature, seizures, delayed myelination, mild hearing loss, and tooth ...
Rina Shimomura, Tomoe Yanagishita, Kumiko Ishiguro, Minobu Shichiji, Takatoshi Sato, Keiko Shimojima Yamamoto, Miho Nagata, Yasuki Ishihara, Yohei Miyashita, Keiko Ishigaki, Satoru Nagata, Yoshihiro Asano, Toshiyuki Yamamoto   +12 more
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Protective mitochondrial fission induced by stress-responsive protein GJA1-20k

eLife, 2021
The Connexin43 gap junction gene GJA1 has one coding exon, but its mRNA undergoes internal translation to generate N-terminal truncated isoforms of Connexin43 with the predominant isoform being only 20 kDa in size (GJA1-20k).
Daisuke Shimura, Esther Nuebel, Rachel Baum, Steven E Valdez, Shaohua Xiao, Junco S Warren, Joseph A Palatinus, TingTing Hong, Jared Rutter, Robin M Shaw   +9 more
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