Results 101 to 110 of about 5,094 (206)
Nature of plasmalemmal functional “hemichannels”
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 The molecular identity of the protein forming "hemichannels" at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and sensitivity to blocking agents.
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Connexin 43‐Enriched Vesicles Improve Synchronization in hiPSC‐Derived Cardiomyocytes
Advanced Science, Volume 13, Issue 33, 15 June 2026.Plasma membrane‐derived Connectosomes enriched in connexin‐43 are produced from donor hiPSCs and applied to hiPSC‐derived cardiomyocytes (hiPSC‐CMs). Connexin‐43 channels on Connectosomes remain functional, strengthening intercellular electrochemical coupling and increasing network synchronization over time.
Nima Momtahan +8 more
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Electrophysiology of Single and Aggregate Cx43 Hemichannels
PLoS ONE, 2012 Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp +3 more
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Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases
BMEMat, Volume 4, Issue 2, June 2026.This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou +6 more
wiley +1 more source
Pharmaceuticals, 2020 To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN ...
Kouji Fukuyama +2 more
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Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source
Frontiers in Physiology, 2014 Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widelyexpressed in the inner ear, are the primary cause of hereditary non–syndromic hearing loss in severalpopulations.
Francesco eZonta +7 more
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Connexin hemichannels: novel mediators of toxicity [PDF]
Archives of Toxicology, 2014 Tissue homeostasis is driven by a myriad of extracellular, intracellular and intercellular signaling networks. Direct communication between neighboring cells is typically controlled by gap junctions (Decrock et al. 2009; Nielsen et al. 2012; Vinken et al. 2011).
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Frontiers in Cellular Neuroscience, 2019 Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez +6 more
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Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations [PDF]
, 2016 Background: Gap junctions facilitate exchange of small molecules between adjacent cells, serving a crucial function for the maintenance of cellular homeostasis.
Aypek, Hande +8 more
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