Results 101 to 110 of about 9,855 (254)
Nature of plasmalemmal functional “hemichannels”
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 The molecular identity of the protein forming "hemichannels" at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and sensitivity to blocking agents.
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Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases
Scientific Reports, 2018 Cytoplasmic membrane-bound connexin 43 (Cx43) proteins oligomerize into hexameric channels (hemichannels) that can sometimes dock with hemichannels on adjacent cells to form gap junctional (GJ) channels. However, the possible role of Cx43 hemichannels in
Wei Li +14 more
semanticscholar +1 more source
Ibrain, Volume 12, Issue 1, Page 65-85, Spring 2026.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
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, 2017 The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50).
Berthoud, Viviana M., Ngezahayo, Anaclet
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Journal of Orthopaedic Research, Volume 44, Issue 3, March 2026.ABSTRACT Osteocytes detect and transduce mechanical cues into biochemical signals that regulate bone remodeling. Connexin 43 (Cx43) is the predominant gap junction protein in osteocytes, but its role in β‐catenin signaling during mechanical loading remains unclear.
Michael A. Friedman +5 more
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Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death. [PDF]
PLoS ONE, 2013 Connexin channels play a critical role in maintaining metabolic homeostasis and transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in humans.
Qian Ren +6 more
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Electrophysiology of Concatameric Pannexin 1 Channels Reveals the Stoichiometry of C-Terminal Autoinhibition [PDF]
, 2011 Codi d'Art Públic: 8008-1 (La República); Reportatge realitzat als dies 4 i 18-7-1990Pericas, Enric (arquitecte); Viaplana, Albert (arquitecte i estructura); Viladomat Massanas, Josep (escultura);Joan Pie (Medalló); Piñón, Helio ...
Chiu, Yu-Hsin +7 more
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Pannexin channels are not gap junction hemichannels [PDF]
Channels, 2011 Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from
Gina E, Sosinsky +12 more
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Connexin43 mutations linked to skin disease have augmented hemichannel activity
Scientific Reports, 2019 Mutations in the gene (GJA1) encoding connexin43 (Cx43) are responsible for several rare genetic disorders, including non-syndromic skin-limited diseases.
M. Srinivas +6 more
semanticscholar +1 more source
MedComm, Volume 7, Issue 3, March 2026.PGC‑1α downregulation in hippocampal astrocytes disrupts ATP release and reduces connexin 43 (CX43) expression, impairing neuro‑glial communication. This promotes enhanced fear memory retrieval in PTSD. Chemogenetic activation of astrocytes or PGC‑1α agonist treatment rescues both CX43 expression and fear behavior, identifying astrocytic PGC‑1α/CX43 as
Juan Wang +6 more
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