Results 101 to 110 of about 4,743 (216)
Nature of plasmalemmal functional “hemichannels”
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2012 The molecular identity of the protein forming "hemichannels" at non-junctional membranes is disputed. The family of gap junction proteins, innexins, connexins, and pannexins share several common features, including permeability characteristics and sensitivity to blocking agents.
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Altered cellular localization and hemichannel activities of KID syndrome associated connexin26 I30N and D50Y mutations [PDF]
, 2016 Background: Gap junctions facilitate exchange of small molecules between adjacent cells, serving a crucial function for the maintenance of cellular homeostasis.
Aypek, Hande +8 more
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Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang +3 more
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Connexin hemichannels: novel mediators of toxicity [PDF]
Archives of Toxicology, 2014 Tissue homeostasis is driven by a myriad of extracellular, intracellular and intercellular signaling networks. Direct communication between neighboring cells is typically controlled by gap junctions (Decrock et al. 2009; Nielsen et al. 2012; Vinken et al. 2011).
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Cataract-causing mutation of human connexin 46 impairs gap junction, but increases hemichannel function and cell death. [PDF]
PLoS ONE, 2013 Connexin channels play a critical role in maintaining metabolic homeostasis and transparency of the lens. Mutations in connexin genes are linked to congenital cataracts in humans.
Qian Ren +6 more
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A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye
Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro +8 more
wiley +1 more source
The Neuroglial Dialog Between Cannabinoids and Hemichannels [PDF]
Frontiers in Molecular Neuroscience, 2018 The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules during physiological and pathological conditions.
Valeria C. Labra +11 more
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Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. [PDF]
, 2011 Inflammation attenuates gap junction (GJ) communication in cultured astrocytes. Here we used a well-characterized model of experimental brain abscess as a tool to query effects of the CNS inflammatory milieu on astrocyte GJ communication and ...
Angle, Amanda +9 more
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Table_1_Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.pdf [PDF]
, 2020 BackgroundEmerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction,
An Aerts (8434218) +8 more
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Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro +8 more
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