Results 121 to 130 of about 4,743 (216)

Cx32 hemichannel opening by cytosolic Ca2+ is inhibited by the R220X mutation that causes Charcot-Marie-Tooth disease [PDF]

, 2017
Mutations of the GJB1 gene encoding connexin 32 (Cx32) cause the X-linked form of Charcot-Marie-Tooth disease (CMTX1), a demyelinating peripheral neuropathy for which there is no cure.
Crispino, Giulia, Leparulo, Alessandro, Giulia Crispino, Mario Bortolozzi, Andrea Carrer, Alessandro Leparulo, Marin, Oriano, Carrer, Andrea, Oriano Marin, Bortolozzi, Mario, Catalin Dacian Ciubotaru, Zonta, Francesco, Ciubotaru, Catalin Dacian, Francesco Zonta   +13 more
core   +1 more source

Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

Biomolecules
In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation.
Kerstin Boengler, Beatrice Mantuano, Shira Toledano, Ofer Binah, Rainer Schulz   +4 more
doaj   +1 more source

Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease [PDF]

, 2017
The pathogenesis of hepatic encephalopathy (HE) in cirrhosis is multifactorial and ammonia is thought to play a key role. Astroglial dysfunction is known to be present in HE.
Abeba Habtetion, De Chiara, F, Francesco De Chiara, Patrick S. Hosford, Nathan Davies, Rajiv Jalan, Hosford, PS, Alexander V. Gourine, Davies, N, Jalan, R, Anna Hadjihambi, Hadjihambi, A, Karagiannis, A, Habtetion, A, Anastassios Karagiannis, Gourine, AV   +15 more
core   +1 more source

Connexin43 Hemichannel-Mediated Regulation of Connexin43

PLoS ONE, 2013
Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we ...
Kai Li, Yuan Chi, Kun Gao, Qiaojing Yan, Hiroyuki Matsue, Masayuki Takeda, Masanori Kitamura, Jian Yao   +7 more
openaire   +4 more sources

Analysis of the Hemichannel properties of Cx26 mutants causing Keratitis-Ichthyosis-Deafness Syndrome [PDF]

, 2011
Keratitis-Ichthyosis-Deafness (KID) Syndrome has been linked with various mutations of the Cx26 encoding GJB2 (Gap Junction beta2) gene. Each mutation was associated with symptoms and severity of varying degree in both adult and neonatal patients.
Mhaske, Pallavi
core   +1 more source

Activity-dependent CO2 production in the axon triggers opening of Connexin32 in the Schwann cell paranode

eLife
Loss of function mutations of Cx32, which is expressed in Schwann cells, cause X-linked Charcot-Marie-Tooth disease, a slowly progressive peripheral neuropathy.
Jack Butler, Lowell Mott, Amol Bhandare, Angus Brown, Nicholas Dale   +4 more
doaj   +1 more source

Nanomechanics of Hemichannel Conformations [PDF]

Journal of Biological Chemistry, 2006
Fei Liu, Fernando Terán Arce, Srinivasan Ramachandran, Ratnesh Lal   +3 more
openaire   +1 more source

Mechanisms of permselectivity of connexin hemichannels to small molecules. [PDF]

J Biol Chem
Lovatt A, Butler J, Dale N.
europepmc   +2 more sources

Analysis of the Hemichannel properties of Cx26 mutants causing Keratitis-Ichthyosis-Deafness Syndrome [PDF]

35 pg.Keratitis-Ichthyosis-Deafness (KID) Syndrome has been linked with various mutations of the Cx26 encoding GJB2 (Gap Junction beta2) gene. Each mutation was associated with symptoms and severity of varying degree in both adult and neonatal patients ...
Mhaske, Pallavi
core  

CO₂-dependent opening of connexin 43 hemichannels. [PDF]

Elife
Dospinescu VM, Mascarenhas A, Butler J, Nijjar S, de Oliveira Taborda K, Connors S, Huang L, Dale N.   +7 more
europepmc   +1 more source