Results 121 to 130 of about 9,855 (254)
Glia, Volume 74, Issue 2, February 2026.Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips +9 more
wiley +1 more source
Frontiers in Physiology, 2014 Mutations of the GJB2 gene encoding the connexin 26 (Cx26) gap junction protein, which is widelyexpressed in the inner ear, are the primary cause of hereditary non–syndromic hearing loss in severalpopulations.
Francesco eZonta +7 more
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 4, Page 1592-1606, 15 February 2026.Abstract figure legend Intricate cellular electrical coupling networks in the heart. Various cell types couple the central cardiomyocyte through gap junctional contacts, with the exception of neurons. Whether ephaptic coupling (EpC) occurs in homocellular or heterocellular contexts beyond cardiomyocyte–cardiomyocyte interactions remains unclear ...
Xiaobo Wu +2 more
wiley +1 more source
Cells, 2020 Clozapine (CLZ) is a gold-standard antipsychotic against treatment-refractory schizophrenia, but is one of the most toxic antipsychotic agents. Pharmacological mechanisms of the double-edged sword clinical action of CLZ remain to be clarified. To explore
Kouji Fukuyama +4 more
doaj +1 more source
Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes
Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth +2 more
wiley +1 more source
Paracrine signaling through plasma membrane hemichannels
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013 Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication provided by junctional channels. Hemichannels not incorporated into gap junctions, called unapposed hemichannels, can open in response to a variety of ...
Wang, Nan +9 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2019 Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2018 Under pro-inflammatory conditions, astrocytes become reactive and acquire a migratory phenotype. Our results show that hemichannels formed by connexin 43 (Cx43) play an important role in Thy-1-induced astrocyte migration. The neuronal protein Thy-1 binds
Raúl Lagos-Cabré +7 more
semanticscholar +1 more source
Conductive and Kinetic Properties of Connexin45 Hemichannels Expressed in Transfected HeLa Cells [PDF]
, 2018 Human HeLa cells transfected with mouse connexin Cx45 were used to examine the conductive and kinetic properties of Cx45 hemichannels. The experiments were carried out on single cells using a voltage-clamp method.
Bader, P., Weingart, R.
core
Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice [PDF]
, 2017 While gap junctions mediate intercellular communication and support liver homeostasis, connexin hemichannels are preferentially opened by pathological stimuli, including inflammation and oxidative stress.
Cogliati, Bruno +15 more
core +2 more sources