Results 131 to 140 of about 9,855 (254)
Modulation of Cx46 hemichannels by nitric oxide
American Journal of Physiology-Cell Physiology, 2009 Gap-junction hemichannels are composed of six protein subunits (connexins). Undocked hemichannels contribute to physiological autocrine/paracrine cell signaling, including release of signaling molecules, cell-volume regulation, and glucose uptake.
Retamal, Mauricio A. +3 more
openaire +5 more sources
Cx26 keratitis ichthyosis deafness syndrome mutations trigger alternative splicing of Cx26 to prevent expression and cause toxicity in vitro [PDF]
, 2019 The Cx26 mRNA has not been reported to undergo alternative splicing. In expressing a series of human keratitis ichthyosis deafness (KID) syndrome mutations of Cx26 (A88V, N14K and A40V), we found the production of a truncated mRNA product.
Cook, Jonathan P. +2 more
core +1 more source
The role of pannexin hemichannels in inflammation and regeneration [PDF]
, 2014 Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue inflammation and regeneration.
Helen P. Makarenkova +1 more
core +1 more source
Connexin-based gap junction hemichannels: Gating mechanisms
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005 Connexins (Cxs) form hemichannels and gap junction channels. Each gap junction channel is composed of two hemichannels, also termed connexons, one from each of the coupled cells. Hemichannels are hexamers assembled in the ER, the Golgi, or a post Golgi compartment. They are transported to the cell surface in vesicles and inserted by vesicle fusion, and
Saez, JC +4 more
openaire +5 more sources
Ammonia mediates cortical hemichannel dysfunction in rodent models of chronic liver disease
Hepatology, 2017 The pathogenesis of hepatic encephalopathy (HE) in cirrhosis is multifactorial and ammonia is thought to play a key role. Astroglial dysfunction is known to be present in HE.
Anna Hadjihambi +7 more
semanticscholar +1 more source
Posttranslational Modifications in Connexins and Pannexins [PDF]
, 2018 Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring ...
Billaud, Marie +4 more
core
GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]
, 2008 The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
core +1 more source
Electrophysiology of Single and Aggregate Cx43 Hemichannels
PLoS ONE, 2012 Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp +3 more
openaire +3 more sources
Pannexin channel and connexin hemichannel expression in vascular function and inflammation
BMC Cell Biology, 2017 Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells.
Daniela Begandt +6 more
semanticscholar +1 more source
Scientific Reports, 2018 Germline missense mutations in GJB2 encoding connexin (Cx) 26 have been found in keratitis, ichthyosis and deafness (KID) syndrome. We explored the effects of three mouse Cx26 mutants (Cx26-G12R, -G45E and -D50N) corresponding to KID syndrome-causative ...
T. Taki +3 more
semanticscholar +1 more source