Results 111 to 120 of about 5,094 (206)

Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

Biomolecules
In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation.
Kerstin Boengler, Beatrice Mantuano, Shira Toledano, Ofer Binah, Rainer Schulz   +4 more
doaj   +1 more source

Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. [PDF]

, 2011
Inflammation attenuates gap junction (GJ) communication in cultured astrocytes. Here we used a well-characterized model of experimental brain abscess as a tool to query effects of the CNS inflammatory milieu on astrocyte GJ communication and ...
Angle, Amanda, Teresa Fritz, Amanda Angle, Kielian, Tammy, Nikolay Karpuk, Maria Burkovetskaya, Karpuk, Nikolay, Burkovetskaya, Maria, Fritz, Teresa, Tammy Kielian   +9 more
core   +1 more source

Connexin Mutations Causing Skin Disease and Deafness Increase Hemichannel Activity and Cell Death when Expressed in Xenopus Oocytes [PDF]

, 2009
Mutations in the GJB2 gene-encoding connexin 26 (Cx26) have been linked to skin disorders and genetic deafness. However, the severity and type of the skin disorders caused by Cx26 mutations are heterogeneous.
DeRosa, Adam M., Adam M. DeRosa, Thomas W. White, Jack R. Lee, White, Thomas W., Lee, Jack R.   +5 more
core   +1 more source

Connexin-43 hemichannel mediated ATP release stimulates fibroblast activation in an in vitro model of diabetic kidney disease

, 2022
Aims: Tubulointerstitial fibrosis is the underlying pathology of diabetic nephropathy and develops in response to aberrant activation of multiple cell types within and around the proximal tubule of the kidney, including extracellular matrix (ECM ...
Claire Hills (17159905), Chelsy L. Cliff (17063201), Bethany Williams (17170132), Paul Squires (17167891), I. Demirel (17925383)   +4 more
core  

Peptidoglycan derived from Staphylococcus epidermidis induces Connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells

, 2010
Gram-positive bacterial cell wall components including PGN (peptidoglycan) elicit a potent pro-inflammatory response in diverse cell types, including endothelial cells, by activating TLR2 (Toll-like receptor 2) signalling. The functional integrity of the
Sue Lang, Jennifer Robertson, Martin, Patricia E.M., Patricia E. Martin, Martin, Patricia E, Lambert, Peter A, Peter A. Lambert, Lambert, Peter A., Robertson, Jennifer, Lang, Sue   +9 more
core   +1 more source

Pelizaeus–Merzbacher-like disease is caused not only by a loss of connexin47 function but also by a hemichannel dysfunction

, 2010
Autosomal recessive mutations in the GJA12/GJC2 gene encoding the gap junction protein connexin47 (C x 47) cause a form of Pelizaeus-Merzbacher-like disease (PMLD) with hypomyelination, nystagmus, impaired psychomotor development and progressive ...
Simone Diekmann, Jutta Gärtner, Marco Henneke, Birgitta C Burckhardt, Diekmann, Simone, Gärtner, Jutta, Henneke, Marco, Burckhardt, Birgitta C.   +7 more
core   +1 more source

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity

, 2017
Connexin 43 (Cx43) hemichannels establish local signaling networks via the release of ATP and other molecules, but their excessive opening may result in cell death. Hence, the activity of Cx43-hemichannels ought to be critically controlled. This involves
Nan Wang, Wang, Nan, Leybaert, Luc, Catheleyne D’hondt, Jean X. Jiang, Jegan Iyyathurai, Bultynck, Geert, Iyyathurai, Jegan, D'hondt, Catheleyne, Geert Bultynck, Jiang, Jean X., Luc Leybaert   +11 more
core   +1 more source

Nanomechanics of Hemichannel Conformations [PDF]

Journal of Biological Chemistry, 2006
Fei Liu, Fernando Terán Arce, Srinivasan Ramachandran, Ratnesh Lal   +3 more
openaire   +1 more source

Connexin 43 hemichannels and related diseases

Antibody Therapeutics
Abstract Connexin 43 (Cx43) protein forms hemichannels (connexons) and gap junctions, with hemichannels consisting of six Cx43 molecules and gap junctions formed by two hemichannels. While gap junctions are prevalent in organs like the heart and liver, hemichannels are found in specific cell types, such as astrocytes and osteocytes ...
Yanfeng Zhang, Francisca M Acosta, Jean X Jiang   +2 more
openaire   +2 more sources

Connexin50 hemichannels are opened by CO₂: implications for lens physiology. [PDF]

Front Physiol
Lovatt A, Bibra F, Wijayapala A, Mui M, Butler J, Dale N.   +5 more
europepmc   +1 more source