Results 111 to 120 of about 9,855 (254)

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock [PDF]

, 2019
Upon intravenous injection of tumour necrosis factor (TNF) in mice, a systemic inflammatory response syndrome (SIRS) is initiated, characterized by an acute cytokine storm and induction of vascular hyperpermeability.
Czekaj, Aleksandra, De Smet, Maarten, Declercq, Wim, Decrock, Elke, Delvaeye, Tinneke, Gonçalves, Amanda, Krysko, Dmitri, Lemeire, Kelly, Leybaert, Luc, Vandenabeele, Peter, Vandenbroucke, Roosmarijn, Verwaerde, Stijn   +11 more
core   +2 more sources

Characterization of Nonjunctional Hemichannels in Caterpillar Cells [PDF]

Journal of Insect Science, 2011
Recent studies have demonstrated that hemichannels, which form gap junctions when paired from apposing cells, may serve additional roles when unpaired including cell adhesion and paracrine communication. Hemichannels in mammals are formed by connexins or pannexins, while in insects they are formed by pannexin homologues termed innexins.
Luo, Kaijun, Turnbull, Matthew W.
openaire   +2 more sources

Overexpression of Cx43: Is It an Effective Approach for the Treatment of Cardiovascular Diseases?

Biomolecules
In the heart, Connexin 43 (Cx43) is involved in intercellular communication through gap junctions and exosomes. In addition, Cx43-formed hemichannels at the plasma membrane are important for ion homeostasis and cellular volume regulation.
Kerstin Boengler, Beatrice Mantuano, Shira Toledano, Ofer Binah, Rainer Schulz   +4 more
doaj   +1 more source

Current and Emerging Pharmacologic Therapies for Diabetic Retinopathy

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 46, Issue 3, March 2026.
ABSTRACT Diabetic retinopathy, a prevalent microvascular complication of diabetes mellitus, is a leading cause of blindness among adults in developed countries. Risk factors include prolonged duration of diabetes, elevated glycosylated hemoglobin levels, hypertension, and dyslipidemia, with rapid glucose reduction also increasing risk for developing ...
Jennifer N. Clements, Julia Mesawich, Cassandra Twisdale   +2 more
wiley   +1 more source

Connexin 43 Hemichannels Are Permeable to ATP [PDF]

The Journal of Neuroscience, 2008
Astrocytes are electrically nonexcitable cells that communicate by means of Ca2+signaling. Long-distance intercellular Ca2+waves are initiated by release of ATP and activation of purinergic receptors on nearby cells. Previous studies have implicated connexin 43 (Cx43) in ATP release, but definitive proof that ATP exits through Cx43 hemichannels does ...
Jian, Kang, Ning, Kang, Ditte, Lovatt, Arnulfo, Torres, Zhuo, Zhao, Jane, Lin, Maiken, Nedergaard   +6 more
openaire   +2 more sources

Rational design of new NO and redox sensitivity into connexin26 hemichannels [PDF]

Open Biology, 2015
CO2 directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer.
Louise Meigh, Daniel Cook, Jie Zhang, Nicholas Dale   +3 more
doaj   +1 more source

Astrocyte Bioenergetic Remodeling as a Central Trait of Disrupted Glucocorticoid Signaling: Mechanisms and Implications for Stress Vulnerability

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Low/brief glucocorticoid (GC) elevations can enhance mitochondrial output (↑ oxygen consumption rate, OCR; ↑ mitochondrial membrane potential, ΔΨm) and Ca2+ buffering, in part via glucocorticoid receptor (GR) trafficking to mitochondria in complexes with Bcl2 and Bag1.
Paweł Hanus, Dorota Frydecka, Michał Ślęzak   +2 more
wiley   +1 more source

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor

Pharmaceuticals, 2020
To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN ...
Kouji Fukuyama, Masashi Fukuzawa, Motohiro Okada   +2 more
doaj   +1 more source

Connexin 43 Mutations Lead to Increased Hemichannel Functionality in Skin Disease

International Journal of Molecular Sciences, 2019
Gap junctional channels are specialized components of the cellular membrane that allow the intercellular passage of small metabolites, ions, and second messengers to maintain homeostasis.
Anthony G. Cocozzelli, T. W. White
semanticscholar   +1 more source

GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis

Animal Genetics, Volume 57, Issue 1, February 2026.
Abstract Palmoplantar keratoderma in humans is a condition defined by an abnormally thickened cornified skin layer on the hands and feet. In animals, the corresponding disease is commonly termed paw pad hyperkeratosis. It can be acquired due to repeated trauma, infections, cancer, or inflammatory dermatoses, or inherited due to pathogenic variants in ...
Stefan J. Rietmann, Joseph Malatos, Vidhya Jagannathan, Tosso Leeb   +3 more
wiley   +1 more source