Results 111 to 120 of about 4,743 (216)

Electrophysiology of Single and Aggregate Cx43 Hemichannels

PLoS ONE, 2012
Connexin43 (Cx43) is the most ubiquitous gap junction protein in the human body and is essential for cell-to-cell communication in a variety of organs and organ systems. As a result, Cx43 is responsible for mediating both electrical and chemical signals, passing dissolved solutes and small signaling molecules between cells in a coordinated fashion ...
Cole Brokamp, Jacob Todd, Carlo Montemagno, David Wendell   +3 more
openaire   +3 more sources

Pelizaeus–Merzbacher-like disease is caused not only by a loss of connexin47 function but also by a hemichannel dysfunction [PDF]

, 2010
Autosomal recessive mutations in the GJA12/GJC2 gene encoding the gap junction protein connexin47 (C x 47) cause a form of Pelizaeus-Merzbacher-like disease (PMLD) with hypomyelination, nystagmus, impaired psychomotor development and progressive ...
Simone Diekmann, Jutta Gärtner, Marco Henneke, Birgitta C Burckhardt, Diekmann, Simone, Gärtner, Jutta, Henneke, Marco, Burckhardt, Birgitta C.   +7 more
core   +1 more source

Upregulated and Hyperactivated Thalamic Connexin 43 Plays Important Roles in Pathomechanisms of Cognitive Impairment and Seizure of Autosomal Dominant Sleep-Related Hypermotor Epilepsy with S284L-Mutant α4 Subunit of Nicotinic ACh Receptor

Pharmaceuticals, 2020
To understand the pathomechanism and pathophysiology of autosomal dominant sleep-related hypermotor epilepsy (ADSHE), we studied functional abnormalities of glutamatergic transmission in thalamocortical pathway from reticular thalamic nucleus (RTN ...
Kouji Fukuyama, Masashi Fukuzawa, Motohiro Okada   +2 more
doaj   +1 more source

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity [PDF]

, 2017
Connexin 43 (Cx43) hemichannels establish local signaling networks via the release of ATP and other molecules, but their excessive opening may result in cell death. Hence, the activity of Cx43-hemichannels ought to be critically controlled. This involves
Nan Wang, Wang, Nan, Leybaert, Luc, Catheleyne D’hondt, Jean X. Jiang, Jegan Iyyathurai, Bultynck, Geert, Iyyathurai, Jegan, D'hondt, Catheleyne, Geert Bultynck, Jiang, Jean X., Luc Leybaert   +11 more
core   +1 more source

Image_3_Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.pdf [PDF]

, 2020
BackgroundEmerging evidence indicates an excess risk of late occurring cardiovascular diseases, especially atherosclerosis, after thoracic cancer radiotherapy. Ionizing radiation (IR) induces cellular effects which may induce endothelial cell dysfunction,
An Aerts (8434218), Luc Leybaert (313676), Elke Decrock (452224), Dornatien Chuo Anang (8533914), Ines Goetschalckx (8533917), Raghda Ramadan (8533908), Delphine Hoorelbeke (8533920), Els Vromans (8533911), Sarah Baatout (440041)   +8 more
core   +1 more source

Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism

Advanced Science, Volume 13, Issue 19, 2 April 2026.
The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying, Hangping Fan, Yunhe Wang, Ruhong Jiang, Dongsheng Cai, Hui Cheng, Hao Wang, Chenyang Jiang, Ping Liang   +8 more
wiley   +1 more source

Connexin Mutations Causing Skin Disease and Deafness Increase Hemichannel Activity and Cell Death when Expressed in Xenopus Oocytes [PDF]

, 2009
Mutations in the GJB2 gene-encoding connexin 26 (Cx26) have been linked to skin disorders and genetic deafness. However, the severity and type of the skin disorders caused by Cx26 mutations are heterogeneous.
DeRosa, Adam M., Adam M. DeRosa, Thomas W. White, Jack R. Lee, White, Thomas W., Lee, Jack R.   +5 more
core   +1 more source

Pharmacological Separation of Mechanosensory Mechanisms in Rat Urinary Bladder Ex Vivo

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT The local response of the bladder wall to stretch is believed to result from the coordinated activation of mechanosensitive ion channels located in the plasma membrane of the cells that form the wall's urothelial and detrusor smooth muscle (DSM) layers.
Igor B. Philyppov, Ganna V. Sotkis, Semen I. Yelyashov, Valeri G. Naidenov, Yaroslav M. Shuba   +4 more
wiley   +1 more source

The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

Frontiers in Cellular Neuroscience, 2019
Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez, Juan E. Oyarzún, Beatriz C. Avendaño, Luis A. Mellado, Carla A. Inostroza, Tanhia F. Alvear, Juan A. Orellana   +6 more
doaj   +1 more source