Results 1 to 10 of about 37,531 (265)
Connexin Channels, Connexin Mimetic Peptides and ATP Release [PDF]
Cell Communication and Adhesion, 2003 Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate.
Luc Leybaert +2 more
exaly +7 more sources
Connexin-43-dependent ATP release mediates macrophage activation during sepsis. [PDF]
eLife, 2019 Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Candinas, Daniel +7 more
core +3 more sources
Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26 [PDF]
Biology, 2021 Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting.
Laura Garcia-Vega +3 more
doaj +3 more sources
The Dual Role of Connexins in Stroke, Neurotrauma, Neurodegenerative and Psychiatric Disorders: A Global Systematic Review. [PDF]
MoleculesBackground: Connexins (Cx) are a family of transmembrane proteins that form gap junctions and connexin hemichannels (HCs), enabling direct intercellular communication within the nervous system.
Rodkin S +6 more
europepmc +2 more sources
Connexin channels and phospholipids: association and modulation [PDF]
BMC Biology, 2009 Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L +3 more
core +3 more sources
Connexin Genes in the Mouse and Human Genome
Cell Communication and Adhesion, 2001 Gap junctions serve for direct intercellular communication by docking of two hemichannels in adjacent cells thereby forming conduits between the cytoplasmic compartments of adjacent cells. Connexin genes code for subunit proteins of gap junction channels
Joachim Degen +2 more
exaly +2 more sources
Mechanisms Underlying Connexin Hemichannel Activation in Disease
International Journal of Molecular Sciences, 2021 Gap junctions and connexin hemichannels mediate intercellular and extracellular communication, respectively. While gap junctions are seen as the “good guys” by controlling homeostasis, connexin hemichannels are considered as the “bad guys”, as their ...
Raf van Campenhout +2 more
exaly +2 more sources
Regulation of connexin expression
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2005 Gap junctions contain cell–cell communicating channels that consist of multimeric proteins called connexins and mediate the exchange of low-molecular-weight metabolites and ions between contacting cells.
Oyamada, Masahito +5 more
core +3 more sources
Role of gap junctions and connexin 43 in cancerogenesis and tumor metastasis [PDF]
Medicinski Podmladak, 2022 Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation.
Savić Ivana +2 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2017 Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia ...
Delmar, Mario +5 more
openaire +4 more sources