Results 1 to 10 of about 40,743 (260)

Connexins and the Epithelial Tissue Barrier: A Focus on Connexin 26 [PDF]

Biology, 2021
Epithelial tissue responds rapidly to environmental triggers and is constantly renewed. This tissue is also highly accessible for therapeutic targeting.
Laura Garcia-Vega, Erin M. O’Shaughnessy, Ahmad Albuloushi, Patricia E. Martin   +3 more
doaj   +3 more sources

Connexin-43-dependent ATP release mediates macrophage activation during sepsis [PDF]

eLife, 2019
Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Michel Dosch, Joël Zindel, Fadi Jebbawi, Nicolas Melin, Daniel Sanchez-Taltavull, Deborah Stroka, Daniel Candinas, Guido Beldi   +7 more
doaj   +3 more sources

Connexin channels, connexin mimetic peptides and ATP release [PDF]

Cell Communication & Adhesion, 2003
Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate.
Braet, K., Braet, Katleen, MARTIN, PEM, VANDAMME, W, Leybaert, Luc, EVANS, WH, Leybaert, L., Cabooter, L., Martin, P. E. M., Vandamme, W., CABOOTER, L, Evans, W. H.   +11 more
core   +6 more sources

The Dual Role of Connexins in Stroke, Neurotrauma, Neurodegenerative and Psychiatric Disorders: A Global Systematic Review [PDF]

Molecules
Background: Connexins (Cx) are a family of transmembrane proteins that form gap junctions and connexin hemichannels (HCs), enabling direct intercellular communication within the nervous system.
Stanislav Rodkin, Mitkhat Gasanov, Alexander Tushev, Elena Belousova, Yulia Gordeeva, Chizaram Nwosu, Anastasia Tolmacheva   +6 more
doaj   +2 more sources

Role of gap junctions and connexin 43 in cancerogenesis and tumor metastasis [PDF]

Medicinski Podmladak, 2022
Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation.
Savić Ivana, Ivanović Nebojša, Oprić Dejan   +2 more
doaj   +1 more source

Enhanced osteoclastic resorption and responsiveness to mechanical load in gap junction deficient bone. [PDF]

PLoS ONE, 2011
Emerging evidence suggests that connexin mediated gap junctional intercellular communication contributes to many aspects of bone biology including bone development, maintenance of bone homeostasis and responsiveness of bone cells to diverse extracellular
Yue Zhang, Emmanuel M Paul, Vikram Sathyendra, Andrew Davison, Neil Sharkey, Sarah Bronson, Sundar Srinivasan, Ted S Gross, Henry J Donahue   +8 more
doaj   +1 more source

Connexins and Diabetes [PDF]

Cardiology Research and Practice, 2012
Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about ...
Josephine A. Wright, Toby Richards, David L. Becker   +2 more
openaire   +3 more sources

Connexin-43 hemichannels orchestrate NOD-like receptor protein-3 (NLRP3) inflammasome activation and sterile inflammation in tubular injury.

, 2023
Background: Without aviable cure, chronic kidney disease is a global health concern. Inflammatory damagein and around the renal tubules dictates disease severity and is contributed to by multiple cell types.
Christos Chadjichristos (17752530), Jessy Renciot (17752536), Claire Hills (17159905), Elena Roger (17752533), Chelsy Cliff (17171551), Gareth Price (17165578), Panagiotis Kavvadas (17752539), Paul Squires (17167891), Safia Hadjadj (17752542)   +8 more
core   +5 more sources

Resveratrol Sensitizes Colorectal Cancer Cells to Cetuximab by Connexin 43 Upregulation-Induced Akt Inhibition

Frontiers in Oncology, 2020
Cetuximab is a monoclonal antibody that acts as an anti-epidermal growth factor receptor (EGFR) agent. Cetuximab inhibits the phosphorylation and activation of EGFR and blocks downstream signal pathways of EGF/EGFR, including Ras-Raf-MAPK and PI3K-Akt ...
Yijia Wang, Yijia Wang, Wenhong Wang, Xiaojing Wu, Chunjun Li, Yaping Huang, Huiyan Zhou, Yu Cui   +7 more
doaj   +1 more source

Connexins in the skeleton [PDF]

Seminars in Cell & Developmental Biology, 2016
Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and osteocytes (bone embedded cells). The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis. The skeletal developmental
Joseph P, Stains, Roberto, Civitelli
openaire   +2 more sources