Results 21 to 30 of about 40,743 (260)

Connexin-43 hemichannel mediated ATP release stimulates fibroblast activation in an in vitro model of diabetic kidney disease

, 2022
Aims: Tubulointerstitial fibrosis is the underlying pathology of diabetic nephropathy and develops in response to aberrant activation of multiple cell types within and around the proximal tubule of the kidney, including extracellular matrix (ECM ...
Claire Hills (17159905), Chelsy L. Cliff (17063201), Bethany Williams (17170132), Paul Squires (17167891), I. Demirel (17925383)   +4 more
core   +5 more sources

Connexin 43 Affects Osteogenic Differentiation of the Posterior Longitudinal Ligament Cells via Regulation of ERK Activity by Stabilizing Runx2 in Ossification

Cellular Physiology and Biochemistry, 2016
Aims: Connexin 43 is one of the most potent gap junction proteins related to osteoblast differentiation and bone formation. We hypothesized that Connexin 43 is a significant factor in osteogenic differentiation in the posterior longitudinal ligament ...
Haisong Yang, Lei Shi, Guodong Shi, Yongfei Guo, Dechun Chen, Deyu Chen, Jiangang Shi   +6 more
doaj   +1 more source

Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells [PDF]

, 2013
Background/Aims: In the current study we examined if the adipocytokine, visfatin, alters connexinmediated intercellular communication in proximal tubule-derived epithelial cells.
Mark J. Wall, Hills, Claire E., Michael I. Kerr, Paul E. Squires, Claire E. Hills, Kerr, Michael I., Squires, Paul E., Wall, Mark J.   +7 more
core   +1 more source

Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium

BMC Medicine, 2008
Background The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex.
Gillespie Mark N, Dobrowolski Radoslaw, Willecke Klaus, Haroon Abu, Elzarrad M Khair, Al-Mehdi Abu-Bakr   +5 more
doaj   +1 more source

Adenovirus-mediated delivery of bFGF small interfering RNA increases levels of connexin 43 in the glioma cell line, U251

Journal of Experimental & Clinical Cancer Research, 2010
Background bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth.
Liu Hongsheng, Xu Xinnu, Wang Jinhuan, Feng Xuequan, Zhang Biao, Lin Na   +5 more
doaj   +1 more source

Connexins in atherosclerosis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Atherosclerosis, a chronic inflammatory disease of the vessel wall, involves multiple cell types of different origins, and complex interactions and signaling pathways between them. Autocrine and paracrine communication pathways provided by cytokines, chemokines, growth factors and lipid mediators are central to atherogenesis.
Pfenniger, Anna, Chanson, Marc, Kwak, Brenda   +2 more
openaire   +4 more sources

Connexin channels and phospholipids: association and modulation

BMC Biology, 2009
Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L, Locke Darren
doaj   +1 more source

Connexins and Pannexins—Similarities and Differences According to the FOD-M Model

Biomedicines, 2022
Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals.
Irena Roterman, Katarzyna Stapor, Piotr Fabian, Leszek Konieczny   +3 more
doaj   +1 more source

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro

BMC Cardiovascular Disorders, 2006
Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy.
Kienast Yvonne, Ullrich Nina D, MacLeod Kenneth T, Spohr Hilmar, Patel Pravina, Themis Michael, Ma Yu-Ling, Tolmachov Oleg, Coutelle Charles, Peters Nicholas S   +9 more
doaj   +1 more source

Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice

Cells, 2022
In the lens, cell homeostasis and transparency are supported by intercellular communication facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations of these connexins are linked to inherited cataracts.
Oscar Jara, Peter J. Minogue, Viviana M. Berthoud, Eric C. Beyer   +3 more
doaj   +1 more source