Results 21 to 30 of about 29,751 (231)

Connexins and Pannexins—Similarities and Differences According to the FOD-M Model

Biomedicines, 2022
Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals.
Irena Roterman, Katarzyna Stapor, Piotr Fabian, Leszek Konieczny   +3 more
doaj   +1 more source

Connexins in atherosclerosis

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Atherosclerosis, a chronic inflammatory disease of the vessel wall, involves multiple cell types of different origins, and complex interactions and signaling pathways between them. Autocrine and paracrine communication pathways provided by cytokines, chemokines, growth factors and lipid mediators are central to atherogenesis.
Pfenniger, Anna, Chanson, Marc, Kwak, Brenda   +2 more
openaire   +4 more sources

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro

BMC Cardiovascular Disorders, 2006
Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy.
Kienast Yvonne, Ullrich Nina D, MacLeod Kenneth T, Spohr Hilmar, Patel Pravina, Themis Michael, Ma Yu-Ling, Tolmachov Oleg, Coutelle Charles, Peters Nicholas S   +9 more
doaj   +1 more source

Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice

Cells, 2022
In the lens, cell homeostasis and transparency are supported by intercellular communication facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations of these connexins are linked to inherited cataracts.
Oscar Jara, Peter J. Minogue, Viviana M. Berthoud, Eric C. Beyer   +3 more
doaj   +1 more source

Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss

Experimental and Molecular Medicine, 2020
Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice.
Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya   +3 more
doaj   +1 more source

Connexin Mutants and Cataracts [PDF]

Frontiers in Pharmacology, 2013
The lens is a multicellular, but avascular tissue that must stay transparent to allow normal transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins can cause cataracts, opacities that disrupt these processes.
Beyer, Eric C., Ebihara, Lisa, Berthoud, Viviana M.   +2 more
openaire   +3 more sources

Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies

BMC Genomics, 2020
Background Based on an initial collecting of database sequences from the gap junction protein gene family (also called connexin genes) in a few teleosts, the naming of these sequences appeared variable. The reasons could be (i) that the structure in this
Svein-Ole Mikalsen, Marni Tausen, Sunnvør í Kongsstovu   +2 more
doaj   +1 more source

Systemic Inflammation Rapidly Induces Reversible Atrial Electrical Remodeling: The Role of Interleukin‐6–Mediated Changes in Connexin Expression

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Systemic inflammation is a strong predictor of atrial fibrillation. A key role for electrical remodeling is increasingly recognized, and experimental data suggest that inflammatory cytokines can directly affect connexins resulting in gap ...
Pietro Enea Lazzerini, Franco Laghi‐Pasini, Maurizio Acampa, Ujala Srivastava, Iacopo Bertolozzi, Beatrice Giabbani, Francesco Finizola, Francesca Vanni, Aleksander Dokollari, Mariarita Natale, Gabriele Cevenini, Enrico Selvi, Nicola Migliacci, Massimo Maccherini, Mohamed Boutjdir, Pier Leopoldo Capecchi   +15 more
doaj   +1 more source

Gap junction proteins and their role in spinal cord injury

Frontiers in Molecular Neuroscience, 2015
Gap junctions are specialized intercellular communication channels that are formed by two hexameric connexin hemichannels, one provided by each of the two adjacent cells.
Ryan S Tonkin, Yilin eMao, Simon J O`Carroll, Louise eNicholson, Colin eGreen, Catherine eGorrie, Gila eMoalem-Taylor   +6 more
doaj   +1 more source

Effects of Alpha-Connexin Carboxyl-Terminal Peptide (aCT1) and Bowman-Birk Protease Inhibitor (BBI) on Canine Oral Mucosal Melanoma (OMM) Cells

Frontiers in Veterinary Science, 2021
Oral mucosal melanomas (OMM) are aggressive cancers in dogs, and are good models for human OMM. Gap junctions are composed of connexin units, which may have altered expression patterns and/or subcellular localization in cancer cells.
Ayami Sato, Ayami Sato, Ivone Izabel Mackowiak da Fonseca, Márcia Kazumi Nagamine, Gabriela Fernandes de Toledo, Rennan Olio, Francisco Javier Hernandez-Blazquez, Tomohiro Yano, Elizabeth Shinmay Yeh, Maria Lucia Zaidan Dagli   +9 more
doaj   +1 more source