Results 21 to 30 of about 56,231 (274)

Connexin 43 Affects Osteogenic Differentiation of the Posterior Longitudinal Ligament Cells via Regulation of ERK Activity by Stabilizing Runx2 in Ossification

Cellular Physiology and Biochemistry, 2016
Aims: Connexin 43 is one of the most potent gap junction proteins related to osteoblast differentiation and bone formation. We hypothesized that Connexin 43 is a significant factor in osteogenic differentiation in the posterior longitudinal ligament ...
Haisong Yang, Lei Shi, Guodong Shi, Yongfei Guo, Dechun Chen, Deyu Chen, Jiangang Shi   +6 more
doaj   +1 more source

Connexin-43 upregulation in micrometastases and tumor vasculature and its role in tumor cell attachment to pulmonary endothelium

BMC Medicine, 2008
Background The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex.
Gillespie Mark N, Dobrowolski Radoslaw, Willecke Klaus, Haroon Abu, Elzarrad M Khair, Al-Mehdi Abu-Bakr   +5 more
doaj   +1 more source

Connexins and Diabetes [PDF]

Cardiology Research and Practice, 2012
Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about ...
Josephine A. Wright, Toby Richards, David L. Becker   +2 more
openaire   +3 more sources

An overview of the focus of the International Gap Junction Conference 2017 and Future Perspectives [PDF]

, 2018
n/
Kwak, Brenda R., Martin, Patricia E.
core   +2 more sources

Adenovirus-mediated delivery of bFGF small interfering RNA increases levels of connexin 43 in the glioma cell line, U251

Journal of Experimental & Clinical Cancer Research, 2010
Background bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth.
Liu Hongsheng, Xu Xinnu, Wang Jinhuan, Feng Xuequan, Zhang Biao, Lin Na   +5 more
doaj   +1 more source

Cues to opening mechanisms from in silico electric field excitation of cx26 hemichannel and in vitro mutagenesis studies in HeLa transfectans [PDF]

, 2018
Connexin channels play numerous essential roles in virtually every organ by mediating solute exchange between adjacent cells, or between cytoplasm and extracellular milieu.
Bruno, Francesca, Buratto, Damiano, Carrer, Andrea, Crispino, Giulia, Mammano, Fabio, Pantano, Sergio, Yang, Guang, Zonta, Francesco   +7 more
core   +1 more source

Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro

BMC Cardiovascular Disorders, 2006
Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy.
Kienast Yvonne, Ullrich Nina D, MacLeod Kenneth T, Spohr Hilmar, Patel Pravina, Themis Michael, Ma Yu-Ling, Tolmachov Oleg, Coutelle Charles, Peters Nicholas S   +9 more
doaj   +1 more source

Degradation and modification of cochlear gap junction proteins in the early development of age-related hearing loss

Experimental and Molecular Medicine, 2020
Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice.
Shori Tajima, Keiko Danzaki, Katsuhisa Ikeda, Kazusaku Kamiya   +3 more
doaj   +1 more source

Connexins and Pannexins—Similarities and Differences According to the FOD-M Model

Biomedicines, 2022
Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals.
Irena Roterman, Katarzyna Stapor, Piotr Fabian, Leszek Konieczny   +3 more
doaj   +1 more source

Connexin channels and phospholipids: association and modulation

BMC Biology, 2009
Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L, Locke Darren
doaj   +1 more source