Results 11 to 20 of about 29,751 (231)
Cold Spring Harbor Perspectives in Biology, 2017 Inherited or acquired alterations in the structure and function of connexin proteins have long been associated with disease. In the present work, we review current knowledge on the role of connexins in diseases associated with the heart, nervous system, cochlea, and skin, as well as cancer and pleiotropic syndromes such as oculodentodigital dysplasia ...
Delmar, Mario +5 more
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Connexins in the skeleton [PDF]
Seminars in Cell & Developmental Biology, 2016 Shaping of the skeleton (modeling) and its maintenance throughout life (remodeling) require coordinated activity among bone forming (osteoblasts) and resorbing cells (osteoclasts) and osteocytes (bone embedded cells). The gap junction protein connexin43 (Cx43) has emerged as a key modulator of skeletal growth and homeostasis. The skeletal developmental
Joseph P, Stains, Roberto, Civitelli
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Cardiology Research and Practice, 2012 Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about ...
Josephine A. Wright +2 more
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Impact of genetic counseling and Connexin-26 and Connexin-30 testing on deaf identity and comprehension of genetic test results in a sample of deaf adults: a prospective, longitudinal study. [PDF]
PLoS ONE, 2014 Using a prospective, longitudinal study design, this paper addresses the impact of genetic counseling and testing for deafness on deaf adults and the Deaf community.
Christina G S Palmer +3 more
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Cellular Physiology and Biochemistry, 2016 Aims: Connexin 43 is one of the most potent gap junction proteins related to osteoblast differentiation and bone formation. We hypothesized that Connexin 43 is a significant factor in osteogenic differentiation in the posterior longitudinal ligament ...
Haisong Yang +6 more
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BMC Medicine, 2008 Background The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex.
Gillespie Mark N +5 more
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Journal of Experimental & Clinical Cancer Research, 2010 Background bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth.
Liu Hongsheng +5 more
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American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2010 Connexins (Cxs) are widely-expressed proteins that form gap junctions in most organs, including the kidney. In the renal vasculature, Cx37, Cx40, Cx43, and Cx45 are expressed, with predominant expression of Cx40 in the endothelial cells and Cx45 in the vascular smooth muscle cells. In the tubules, there is morphological evidence for the presence of gap
Hanner, Fiona +3 more
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Connexin channels and phospholipids: association and modulation
BMC Biology, 2009 Background For membrane proteins, lipids provide a structural framework and means to modulate function. Paired connexin hemichannels form the intercellular channels that compose gap junction plaques while unpaired hemichannels have regulated functions in
Harris Andrew L, Locke Darren
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Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. [PDF]
PLoS ONE, 2013 Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Travis P Barr +5 more
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