Results 1 to 10 of about 5,415 (133)

HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]

FASEB J
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K, Scholz JK, Ursu R, Schödel J, Grampp S, Naas S, Lauer V, Schiffer M, Büttner-Herold M, Buchholz B, Kraus A.   +10 more
europepmc   +2 more sources

Pannexin 1 regulates postnatal neural stem and progenitor cell proliferation

Neural Development, 2012
Background Pannexin 1 forms ion and metabolite permeable hexameric channels and is abundantly expressed in the brain. After discovering pannexin 1 expression in postnatal neural stem and progenitor cells we sought to elucidate its functional role in ...
Leigh E Wicki-Stordeur, Leigh Anne Swayne, Swayne Leigh Anne   +2 more
exaly   +3 more sources

Pannexin 1 Modulates Axonal Growth in Mouse Peripheral Nerves

Frontiers in Cellular Neuroscience, 2017
The pannexin family of channels consists of three members—pannexin-1 (Panx1), pannexin-2 (Panx2), and pannexin-3 (Panx3) that enable the exchange of metabolites and signaling molecules between intracellular and extracellular compartments.
Holly M Howarth, Valery I Shestopalov, Helen P Makarenkova   +2 more
exaly   +3 more sources

Prothrombotic Activation of Platelet Pannexin-1 Channels in Antiphospholipid Syndrome. [PDF]

Arthritis Rheumatol
Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
de Moraes Mazetto Fonseca B, NaveenKumar SK, Yalavarthi S, Sugur K, Newman TG, Hoy CK, Sarosh C, Schaefer JK, Tambralli A, Madison JA, Zuo Y, Orsi FA, Holinstat M, Knight JS.   +13 more
europepmc   +2 more sources

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport. [PDF]

Cancer Sci
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Tsuruda T, Kodama M, Nakayama KI.
europepmc   +2 more sources

Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns

PLoS Biology, 2022
Astroglial release of molecules is thought to actively modulate neuronal activity, but the nature, release pathway, and cellular targets of these neuroactive molecules are still unclear.
Flora Vasile, Elena Dossi, Julien Moulard, Pascal Ezan, Laure Lecoin, Martine Cohen-Salmon, Philippe Mailly, Marc Le Bert, Isabelle Couillin, Alexis Bemelmans, Nathalie Rouach   +10 more
doaj   +2 more sources

Plasma and aqueous humor levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy [PDF]

International Journal of Ophthalmology, 2022
AIM: To evaluate plasma and aqueous levels of adiponutrin and pannexin 1 in patients with and without diabetic retinopathy. METHODS: The study included three age and gender-matched groups of 20 cataract patients with no diabetes or additional disease ...
Fatih Cem Gül, Sabiha Güngör Kobat, Fatih Çelik, Süleyman Aydin, Ramazan Fazil Akkoç   +4 more
doaj   +1 more source

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation

Nature Communications, 2022
Pannexin-1 ion channels on endothelial cells regulate vascular inflammation and remodeling to mediate aortic aneurysm formation. Pharmacological blockade of Pannexin-1 channels may offer translational therapeutic mitigation of aneurysmal pathology.
Amanda C. Filiberto, Michael D. Spinosa, Craig T. Elder, Gang Su, Victoria Leroy, Zachary Ladd, Guanyi Lu, J. Hunter Mehaffey, Morgan D. Salmon, Robert B. Hawkins, Kodi S. Ravichandran, Brant E. Isakson, Gilbert R. Upchurch, Ashish K. Sharma   +13 more
doaj   +1 more source

Cross-Activation of Hemichannels/Gap Junctions and Immunoglobulin-Like Domains in Innate–Adaptive Immune Responses

Frontiers in Immunology, 2022
Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng, Jiang-Hui Meng, Chang-Xu Chen, Chang-Xu Chen, Mohammad R. Ahmadian, Hong Zan, Kai-Jun Luo, Kai-Jun Luo, Jean X. Jiang   +8 more
doaj   +1 more source

Connexins evolved after early chordates lost innexin diversity

eLife, 2022
Gap junction channels are formed by two unrelated protein families. Non-chordates use the primordial innexins, while chordates use connexins that superseded the gap junction function of innexins.
Georg Welzel, Stefan Schuster
doaj   +1 more source