Results 31 to 40 of about 5,491 (175)
Connexins and Pannexins—Similarities and Differences According to the FOD-M Model
Biomedicines, 2022 Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals.
Irena Roterman +3 more
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Connexin and pannexin channels in cancer [PDF]
BMC Cell Biology, 2016 Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and ...
Jiang, Jean X., Penuela, Silvia
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Physiological Reports, 2023 Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov +5 more
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P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]
PLoS ONE, 2013 We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung +7 more
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Posttranslational Modifications in Connexins and Pannexins [PDF]
The Journal of Membrane Biology, 2012 Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function.
Scott R, Johnstone +4 more
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The cellular life of pannexins [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractThe mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2, and Panx3 has received considerable attention in the last 10 years given their newly discovered physiological roles in development and disease. Pannexins exhibit diverse subcellular profiles indicating that they may serve distinct roles in cells and tissues of
Silvia Penuela, Dale W. Laird
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Expression of connexins and pannexins in diseased human liver
EXCLI Journal : Experimental and Clinical Sciences, 2022 Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy +8 more
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Innexin and pannexin channels and their signaling [PDF]
FEBS Letters, 2014 Innexins are bifunctional membrane proteins in invertebrates, forming gap junctions as well as non‐junctional membrane channels (innexons). Their vertebrate analogues, the pannexins, have not only lost the ability to form gap junctions but are also prevented from it by glycosylation.
Dahl, Gerhard, Muller, Kenneth J.
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Connexins and Pannexins in cerebral ischemia
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018 A common cause of mortality and long-term adult disability, cerebral ischemia or brain ischemia imposes a significant health and financial burden on communities worldwide. Cerebral ischemia is a condition that arises from a sudden loss of blood flow and consequent failure to meet the high metabolic demands of the brain. The lack of blood flow initiates
Yeri Kim +5 more
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Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword
Frontiers in Molecular Neuroscience, 2018 The classical view of synapses as the functional contact between presynaptic and postsynaptic neurons has been challenged in recent years by the emerging regulatory role of glial cells.
Verónica Abudara +8 more
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