Results 31 to 40 of about 7,051 (198)
Probenecid blocks human P2X7 receptor-induced dye uptake via a pannexin-1 independent mechanism. [PDF]
PLoS ONE, 2014 P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein ...
Archana Bhaskaracharya +7 more
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Connexin and pannexin channels in cancer [PDF]
BMC Cell Biology, 2016 Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and ...
Jiang, Jean X., Penuela, Silvia
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The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition
eLife, 2020 Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski +5 more
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Frontiers in Neurology, 2022 AimPrevious studies have proved that inhibiting inflammasome activation provides neuroprotection against early brain injury (EBI) after subarachnoid hemorrhage (SAH), which is mainly focused on the microglial inflammatory response, but the potential role
Yonghe Zheng +6 more
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Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]
, 2006 Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V +31 more
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Pannexins in Acute Kidney Injury [PDF]
Nephron, 2019 Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently effluxes ATP and plays a central role in the progression of inflammatory ...
Nabin, Poudel, Mark D, Okusa
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Role of astroglial hemichannels and pannexons in Memory and Neurodegenerative diseases
Frontiers in Integrative Neuroscience, 2016 Under physiological conditions, astroglial hemichannels and pannexin channels allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory.
Juan Andrés Orellana +3 more
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Connexins and Pannexins—Similarities and Differences According to the FOD-M Model
Biomedicines, 2022 Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals.
Irena Roterman +3 more
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Pannexin channels and ischaemia [PDF]
The Journal of Physiology, 2014 AbstractAn ischaemic stroke occurs during loss of blood flow in the brain from the occlusion of a blood vessel. The ischaemia itself comprises a complex array of insults, including oxygen and glucose deprivation (OGD), glutamate excitotoxicity, acidification/hypercapnia, and loss of sheer forces.
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Innexin and pannexin channels and their signaling [PDF]
FEBS Letters, 2014 Innexins are bifunctional membrane proteins in invertebrates, forming gap junctions as well as non‐junctional membrane channels (innexons). Their vertebrate analogues, the pannexins, have not only lost the ability to form gap junctions but are also prevented from it by glycosylation.
Dahl, Gerhard, Muller, Kenneth J.
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