Results 41 to 50 of about 7,051 (198)

Posttranslational Modifications in Connexins and Pannexins [PDF]

The Journal of Membrane Biology, 2012
Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function.
Scott R, Johnstone, Marie, Billaud, Alexander W, Lohman, Evan P, Taddeo, Brant E, Isakson   +4 more
openaire   +2 more sources

Probenecid slows disease progression in a murine model of autosomal dominant polycystic kidney disease

Physiological Reports, 2023
Development of autosomal dominant polycystic kidney disease (ADPKD) involves renal epithelial cell abnormalities. Cystic fluid contains a high level of ATP that, among other effects, leads to a reduced reabsorption of electrolytes in cyst‐lining cells ...
Sergey N. Arkhipov, D'Anna L. Potter, Regina F. Sultanova, Daria V. Ilatovskaya, Peter C. Harris, Tengis S. Pavlov   +5 more
doaj   +1 more source

P2X4 assembles with P2X7 and pannexin-1 in gingival epithelial cells and modulates ATP-induced reactive oxygen species production and inflammasome activation. [PDF]

PLoS ONE, 2013
We have previously reported that Porphyromonas gingivalis infection of gingival epithelial cells (GEC) requires an exogenous danger signal such as ATP to activate an inflammasome and caspase-1, thereby inducing secretion of interleukin (IL)-1β ...
Shu-Chen Hung, Chul Hee Choi, Najwane Said-Sadier, Larry Johnson, Kalina Rosenova Atanasova, Hanen Sellami, Özlem Yilmaz, David M Ojcius   +7 more
doaj   +1 more source

Expression of connexins and pannexins in diseased human liver

EXCLI Journal : Experimental and Clinical Sciences, 2022
Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy, Vânia Vilas-Boas, Eva Gijbels, Bart Vanderborght, Lindsey Devisscher, Bruno Cogliati, Bert Van Den Bossche, Isabelle Colle, Mathieu Vinken   +8 more
doaj   +1 more source

Pannexins in ischemia-induced neurodegeneration [PDF]

Proceedings of the National Academy of Sciences, 2011
Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed experiments in
Bargiotas, Panagiotis, Krenz, Antje, Hormuzdi, Sheriar G., Ridder, Dirk A., Herb, Anne, Barakat, Waleed, Penuela, Silvia, von Engelhardt, Jakob, Monyer, Hannah, Schwaninger, Markus   +9 more
openaire   +3 more sources

The biochemistry and function of pannexin channels

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Three family members compose the pannexin family of channel-forming glycoproteins (Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single-membrane channels that are regulated by post-translational modifications, channel intermixing, and sub-cellular expression profiles.
Penuela, Silvia, Gehi, Ruchi, Laird, Dale W.   +2 more
openaire   +2 more sources

Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword

Frontiers in Molecular Neuroscience, 2018
The classical view of synapses as the functional contact between presynaptic and postsynaptic neurons has been challenged in recent years by the emerging regulatory role of glial cells.
Verónica Abudara, Mauricio A. Retamal, Mauricio A. Retamal, Mauricio A. Retamal, Rodrigo Del Rio, Rodrigo Del Rio, Rodrigo Del Rio, Juan A. Orellana, Juan A. Orellana   +8 more
doaj   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source

Connexins and Pannexins in cerebral ischemia

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018
A common cause of mortality and long-term adult disability, cerebral ischemia or brain ischemia imposes a significant health and financial burden on communities worldwide. Cerebral ischemia is a condition that arises from a sudden loss of blood flow and consequent failure to meet the high metabolic demands of the brain. The lack of blood flow initiates
Yeri Kim, Joanne O. Davidson, Colin R. Green, Louise F.B. Nicholson, Simon J. O'Carroll, Jie Zhang   +5 more
openaire   +2 more sources

The Role of Connexin and Pannexin Channels in Perinatal Brain Injury and Inflammation

Frontiers in Physiology, 2019
Perinatal brain injury remains a major cause of death and life-long disability. Perinatal brain injury is typically associated with hypoxia-ischemia and/or infection/inflammation.
Kelly Q. Zhou, Colin R. Green, Laura Bennet, Alistair J. Gunn, Joanne O. Davidson   +4 more
doaj   +1 more source