Results 41 to 50 of about 6,586 (171)
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
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MECHANISTIC AND STRUCTURAL STUDIES OF PANNEXIN CHANNELS
, 2018 Pannexin channels are a family of recently discovered membrane proteins found in nearly every tissue of the human body. These channels have been classified as large ‘pore forming’ proteins which, when activated, create a passageway through the cell ...
Michalski, Kevin
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Connexin43- and Pannexin-Based Channels in Neuroinflammation and Cerebral Neuropathies
Frontiers in Molecular Neuroscience, 2017 Connexins (Cx) are largely represented in the central nervous system (CNS) with 11 Cx isoforms forming intercellular channels. Moreover, in the CNS, Cx43 can form hemichannels (HCs) at non-junctional membrane as does the related channel-forming Pannexin1
Denis Sarrouilhe +2 more
doaj +1 more source
When can AlphaFold predict the oligomeric states of proteins?
Protein Science, Volume 35, Issue 7, July 2026.Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley +1 more source
Pannexin channels are not gap junction hemichannels
, 2011 Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins, and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins,
Dahl, Gerhard +25 more
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Pannexin-1 in silico modeling towards physiological and pathological functioning
, 2020 The transmembrane pore protein Pannexin-1 (Panx1) forms channels allowing the release of purine nucleotides and participates in processes related to purinergic signaling, including blood pressure regulation, apoptotic cell clearance, and neuropathic pain.
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, 2022 Background: In preclinical models, the pannexin-1 channel has been shown to be involved in blood pressure regulation through an effect on peripheral vascular resistance. Pannexin-1 releases ATP, which can activate constrictive purinergic receptors on the
Gliemann, Lasse +5 more
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Expression of connexins and pannexins in diseased human liver
EXCLI Journal : Experimental and Clinical Sciences, 2022 Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy +8 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra +7 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source