Results 61 to 70 of about 6,586 (171)
The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes
, 2009 The inflammasome is a multiprotein complex involved in innate immunity. Activation of the inflammasome causes the processing and release of the cytokines interleukins 1β and 18. In primary macrophages, potassium ion flux and the membrane channel pannexin
Locovei, Silviu +7 more
core +1 more source
Activation of pannexin-1 mediates triglyceride-induced macrophage cell death. [PDF]
, 2020 The accumulation of triglycerides (TGs) in macrophages induces cell death, a risk factor in the pathogenesis of atherosclerosis. We had previously reported that TG-induced macrophage death is triggered by caspase-1 and -2, therefore we investigated the ...
Kim, Sung +3 more
core +1 more source
The two faces of pannexins: new roles in inflammation and repair
Journal of Inflammation Research, 2018 Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj
Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury
Frontiers in Physiology, 2014 In case of traumatic brain injury (TBI), occurrence of central nervous tissue damage is frequently aligned with local modulations of neuronal and glial gap junction channel expression levels.
Nora eProchnow
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm +3 more
wiley +1 more source
Source_file.xlsxCryo-EM structures of Pannexin 1 and 3 reveal differences among Pannexin isoforms
Pannexins are single-membrane large-pore ion channels that releases ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Aravind Penmatsa (18020539) +2 more
core +1 more source
Low levels of pannexin‐1 in Behçet’s syndrome
, 2019 Objective Behcet's syndrome (BS) is a chronic, multisystemic and inflammatory syndrome. In our study, we aimed to compare the initiator, effector and inflammatory caspases and pannexin channel protein, which is thought to have an activity in inflammation,
DOĞAN, HALEF OKAN +9 more
core +2 more sources
Investigation of olfactory function in a Panx1 knock out mouse model
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Stefan eKurtenbach +7 more
doaj +1 more source
Pannexin-1 and other anion channels in platelets and megakaryocytes
, 2015 Platelet ion channels are essential for Ca2+-influx, maintaining the resting membrane potential and cell volume regulation. Cation channels have been widely studied but few reports of platelet anion channels exist.
Kirk Allen Taylor (7667516)
core
Pathological Roles of Astrocytes in Traumatic Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu +7 more
wiley +1 more source