Results 81 to 90 of about 6,586 (171)

Gating Mechanism of ATP Release Pannexin Channels

, 2022
95 pagesPannexins (Panx1-3) are members of the emerging large-pore channel family. Their ubiquitous expression and ability to release small signaling molecules such as ATP has implicated pannexins in a host of critical cell signaling roles.
Henze, Erik Keone
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The Opening of Connexin 43 Hemichannels Alters Hippocampal Astrocyte Function and Neuronal Survival in Prenatally LPS-Exposed Adult Offspring

Frontiers in Cellular Neuroscience, 2019
Clinical evidence has revealed that children born from mothers exposed to viral and bacterial pathogens during pregnancy are more likely to suffer various neurological disorders including schizophrenia, autism bipolar disorder, major depression, epilepsy,
Carolina E. Chávez, Juan E. Oyarzún, Beatriz C. Avendaño, Luis A. Mellado, Carla A. Inostroza, Tanhia F. Alvear, Juan A. Orellana   +6 more
doaj   +1 more source

Effect of 6 Weeks Endurance Exercise on Hippocampal Pannexin-1 and NLRP-1 Protein Levels in Experimental Diabetic Male Wistar Rats

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Diabetes is one of the most common metabolic diseases that is associated with high blood sugar and can cause disorders of the central nervous system.
Mohammad Rami, Mohammad Fathi, Masoud Rahmati, Mohammad Reza Tabandeh   +3 more
doaj  

Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton

Frontiers in Physiology, 2014
Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce, Leigh Elizabeth Wicki-Stordeur, Leigh Anne eSwayne, Leigh Anne eSwayne, Leigh Anne eSwayne, Leigh Anne eSwayne   +5 more
doaj   +1 more source

Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

, 2021
Dysregulation of retinal function in the early stages of light-induced retinal degeneration involves pannexins and connexins. These two types of proteins may contribute to channels that release ATP, leading to activation of the inflammasome pathway ...
Colin R. Green, Mohd N. Mat Nor, Monica L. Acosta, Ilva D. Rupenthal   +3 more
core   +1 more source

The role of pannexin/purinergic signaling in intervascular communication from capillaries during skeletal muscle contraction in male Golden hamsters

Physiological Reports
We sought to determine the physiological relevance of pannexin/purinergic‐dependent signaling in mediating conducted vasodilation elicited by capillary stimulation through skeletal muscle contraction.
Iain R. Lamb, Nicole M. Novielli‐Kuntz, Coral L. Murrant   +2 more
doaj   +1 more source

Differential role of the pannexin-1/ATP/P2X7 axis in IL-1β release by human monocytes [PDF]

, 2017
IL - 1 β release is integral to the innate immune system. The release of mature IL - 1 β depends on two regulated events; (i) the de novo induction of pro - IL - 1 β , generally via NF κ B - depend ent transduction pathways and (ii) the assembly ...
Mark J. Paul‐Clark, Paul-Clark, Mark J., Mitchell, JA, Kirkby, NS, William R. Wright, Parzych, K, Wright, WR, Parzych, Katarzyna, Paul-Clark, M, Katarzyna Parzych, Zetterqvist, A, Jane A. Mitchell, Wright, William R., Kirkby, Nicholas S, Zetterqvist, Anna V., Mitchell, Jane A, Anna V. Zetterqvist, Nicholas S. Kirkby   +17 more
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The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

Frontiers in Cellular Neuroscience, 2017
Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to
Farraj Albalawi, Farraj Albalawi, Wennan Lu, Jonathan M. Beckel, Jonathan M. Beckel, Jason C. Lim, Stuart A. McCaughey, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell   +9 more
doaj   +1 more source

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

, 2011
Apoptotic cell death is important for embryonic development, immune cell homeostasis, and pathogen elimination. Innate immune cells also undergo a very rapid form of cell death termed pyroptosis after activating the protease caspase-1.
Shahram Misaghi, James E. Cupp, David Hackos, Salina Louie, Yan Qu, Vishva M. Dixit, Laurie L. Gilmour, George R. Dubyak, Kim Newton   +8 more
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Die kardiale Phänotypisierung von TASK-1- und Pannexin-1-defizienten Mäusen

, 2016
Erkrankungen des Herz-Kreislauf-Systems stellen weltweit die häufigste Todesursache dar. 40 % der Todesfälle in Deutschland lassen sich darauf zurückführen.
Schulte, Stella
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