Results 81 to 90 of about 7,051 (198)

The two faces of pannexins: new roles in inflammation and repair

Journal of Inflammation Research, 2018
Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj  

When can AlphaFold predict the oligomeric states of proteins?

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley   +1 more source

Role of Connexins and Pannexins in Ischemic Stroke

Current Medicinal Chemistry, 2014
Synaptic plasticity requires careful synchronization and coordination of neurons and glial cells via various mechanisms of intercellular communication. Among them, are those mediated by i) connexin gap junction channels (GJCs), ii) connexin hemichannels and iii) pannexin channels.
Orellana Roca, Juan Andrés, Avendaño, B.C., Montero, T.D.   +2 more
openaire   +5 more sources

Roles of connexins and pannexins in digestive homeostasis [PDF]

Cellular and Molecular Life Sciences, 2015
Connexin proteins are abundantly present in the digestive system. They primarily form gap junctions, which control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions drive a plethora of gastrointestinal and hepatic functional features, including gastric and gut motility, gastric acid secretion, intestinal innate ...
Michaël Maes, Bruno Cogliati, Sara Crespo Yanguas, Joost Willebrords, Mathieu Vinken   +4 more
openaire   +3 more sources

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

Frontiers in Cellular Neuroscience, 2017
Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to
Farraj Albalawi, Farraj Albalawi, Wennan Lu, Jonathan M. Beckel, Jonathan M. Beckel, Jason C. Lim, Stuart A. McCaughey, Claire H. Mitchell, Claire H. Mitchell, Claire H. Mitchell   +9 more
doaj   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Pannexin channels are not gap junction hemichannels

, 2011
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins, and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins,
Dahl, Gerhard, Spray, David C, Daniela Boassa, Christian C. Naus, Thompson, Roger J, Rolf Dermietzel, MacVicar, Brian, Hong-Bo Zhao, Gina E. Sosinsky, Naus, Christian C, Penuela, Silvia, Gerhard Dahl, Roger J. Thompson, Zhao, Hong-Bo, Heather S. Duffy, Boassa, Daniela, Dermietzel, Rolf, David C. Spray, Duffy, Heather S, Silvia Penuela, Sosinsky, Gina E, Brian MacVicar, Scemes, Eliana, Laird, Dale W, Dale W. Laird, Eliana Scemes   +25 more
core   +1 more source

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.
Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon, Sotirios Tetradis, Rolando Vernal, Fabio Renato Manzolli Leite, Thomas E. Van Dyke   +4 more
wiley   +1 more source

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats

The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe, Audrys Pauza, Olivia M. S. Gold, Xin Shen, Fernanda Brognara, Rosanna Roberts Nonu, Dylan K. Pen, Aabharika Bose, Emma N. Bardsley, Anna P. Ponnampalam, Davi J. A. Moraes, Julian F. R. Paton   +11 more
wiley   +1 more source

Connexins and pannexins [PDF]

Spermatogenesis, 2011
Gap junctions and connexins are critical for coordinating cellular functions in complex epithelia. In recent years there has been increased interest in understanding the regulation and function of gap junctions in both the testis and epididymis. Studies in transgenic mice in which connexin 43 (Cx43) is mutated or is knocked down only in Sertoli cells ...
openaire   +3 more sources