Results 91 to 100 of about 6,586 (171)
Pannexin 1 forms an anion-selective channel
, 2012 Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO 3 ->I ...
Ma, Weihong +6 more
core +1 more source
Regulation of Pannexin 1 Channels by ATP
, 2010 Pannexins represent a recently discovered second family of gap junction proteins in vertebrates. However, instead of forming intercellular gap junction channels like connexins, pannexins operate as unpaired pannexons, allowing the flux of molecules from ...
Qiu, Feng
core
The role of pannexin channels in small arteries [PDF]
, 2016 Pannexins (Panx) are membrane bound channels which allow the exchange of molecules, particularly ATP, between the cytoplasm and the extracellular space.
Mokori, E.B.
core
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation
Molecular & Cellular Oncology, 2019 Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined.
Benjamin Demarco +2 more
doaj +1 more source
, 2007 SummaryCryopyrin is essential for caspase-1 activation triggered by Toll-like receptor (TLR) ligands in the presence of adenosine triphosphate (ATP). However, the events linking bacterial products and ATP to cryopyrin remain unclear.
Kim, Yun-Gi +23 more
core +1 more source
Pannexin channels in inflammation and tumorigenesis
Frontiers in Cell and Developmental BiologyPannexin (Panx) channels are oligomeric heptamers of PANX proteins, comprising Panx1, Panx2 and Panx3. These channels facilitate the extracellular release of signaling molecules up to 1.5 kDa in size, including adenosine triphosphate (ATP), amino acids ...
Mengmeng Jiang +5 more
doaj +1 more source
Tumor-suppressive effects of pannexin 1 in C6 glioma cells
, 2007 Mammalian gap junction proteins, connexins, have long been implicated in tumor suppression. Recently, a novel family of proteins named pannexins has been identified as the mammalian counterpart of the invertebrate gap junction proteins, innexins. To date,
Bruzzone, R +5 more
core +1 more source
Pannexin 1 in erythrocytes: Function without a gap
, 2006 ATP is a widely used extracellular signaling molecule. The mechanism of ATP release from cells is presently unresolved and may be either vesicular or channel-mediated. Erythrocytes release ATP in response to low oxygen or to shear stress.
Locovei, Silviu +2 more
core +1 more source
Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes
, 2010 Erythrocytes release ATP in response to exposure to the physiological stimulus of lowered oxygen (O2) tension as well as pharmacological activation of the prostacyclin receptor (IPR).
Terrance M. Egan +6 more
core +1 more source
The role of pannexin channels in small arteries [PDF]
Pannexins (Panx) are membrane bound channels which allow the exchange of molecules, particularly ATP, between the cytoplasm and the extracellular space.
Mokori, E.B.
core