Results 71 to 80 of about 6,586 (171)
Molecular pathways of pannexin1-mediated neurotoxicity
Frontiers in Physiology, 2014 Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da. Panx1 activity is implicated in paracrine signaling and inflammasome
Valery I. Shestopalov +4 more
doaj +1 more source
Biomolecules, 2020 Pannexin 1 (Panx1) is a ubiquitously expressed hexameric integral membrane protein known to function as an adenosine triphosphate (ATP) release channel. Panx1 proteins exist in unglycosylated core form (Gly0).
Ksenia Timonina +2 more
doaj +1 more source
Diabetic Medicine, Volume 43, Issue 4, April 2026.Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward +4 more
wiley +1 more source
A “Swell” Way to Regulate Pannexin-Mediated ATP Release
, 2011 TRPV4 and RhoA signaling act upstream of pannexin 1 to mediate ATP release induced by osmotic cell swelling.
Heather M. Thompson
core +1 more source
A taste for ATP: neurotransmission in taste buds
Frontiers in Cellular Neuroscience, 2013 Not only is ATP a ubiquitous source of energy but it is also used widely as an intercellular signal. For example, keratinocytes release ATP in response to numerous external stimuli including pressure, heat and chemical insult. The released ATP activates
Thomas E. Finger, Sue C Kinnamon
doaj +1 more source
The Journal of Physiology, Volume 604, Issue 7, Page 2816-2844, 1 April 2026.Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Yoshiaki Furusawa +9 more
wiley +1 more source
Activation and Inhibition of Pannexin 1 Channels
, 2015 Pannexin 1 is one of three pannexins, a vertebrate protein family related to the invertebrate innexins. Unlike its innexin relatives, Pannexin 1 does not form gap junctions in vivo, but it does form plasma membrane channels that act as ATP release ...
Jackson, David
core
Measuring the amount of the channel protein pannexin 1 across neuronal development
, 2022 My Presentation is on Pannexin 1 an ATP channel protein in the brain. I have analyzed both the theoretical side as well as the practical side of this protein.
Irwin, Eamonn
core
Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis
eLife, 2020 ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human ...
Hiromi Imamura +8 more
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Sympathetic vasoconstriction takes an unexpected pannexin detour
, 2015 Sympathetic vasoconstriction plays an important role in the control of blood pressure and the distribution of blood flow. In this issue of Science Signaling, Billaud et al.
Schak Nielsen, Morten
core +1 more source