Results 71 to 80 of about 5,491 (175)
The two faces of pannexins: new roles in inflammation and repair
Journal of Inflammation Research, 2018 Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
doaj
Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu +4 more
wiley +1 more source
The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Frontiers in Cellular Neuroscience, 2017 Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to
Farraj Albalawi +9 more
doaj +1 more source
Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang +3 more
wiley +1 more source
Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro +8 more
wiley +1 more source
Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases
MedComm, Volume 7, Issue 5, May 2026.1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang +6 more
wiley +1 more source
Role of Connexins and Pannexins in Ischemic Stroke
Current Medicinal Chemistry, 2014 Synaptic plasticity requires careful synchronization and coordination of neurons and glial cells via various mechanisms of intercellular communication. Among them, are those mediated by i) connexin gap junction channels (GJCs), ii) connexin hemichannels and iii) pannexin channels.
Orellana Roca, Juan Andrés +2 more
openaire +5 more sources
Involvement of gap junction channels in the pathophysiology of migraine with aura
Frontiers in Physiology, 2014 Migraine is a common, recurrent and disabling primary headache disorder with a genetic component which affects up to 20 % of the population. One third of all patients with migraine experiences aura, a focal neurological disturbance that manifests itself ...
Denis eSarrouilhe +2 more
doaj +1 more source
Innexins: Expression, Regulation, and Functions
Frontiers in Physiology, 2018 The innexin (Inx) proteins form gap junction channels and non-junctional channels (named hemichannels) in invertebrates. These channels participate in cellular communication playing a relevant role in several physiological processes.
Juan Güiza +4 more
doaj +1 more source
Pannexin-1 channels bridge apoptosis to NLRP3 inflammasome activation
Molecular & Cellular Oncology, 2019 Apoptosis can promote inflammation by triggering activation of the NLRP3 inflammasome (NLR family, pyrin domain containing 3). However, the molecular mechanisms regulating these processes are ill-defined.
Benjamin Demarco +2 more
doaj +1 more source