Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function [PDF]
Frontiers in Molecular Neuroscience, 2017 Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Veronica Zorzi +2 more
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Investigation of olfactory function in a Panx1 knock out mouse model [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Stefan Kurtenbach +2 more
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A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model [PDF]
Frontiers in Molecular Neuroscience, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Paige Whyte-Fagundes +2 more
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The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent [PDF]
ASN Neuro, 2021 Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes the reduction of epileptiform activity and ictal ...
Price Obot +3 more
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Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
Military Medical ResearchBackground The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.
Qu Xing +7 more
doaj +4 more sources
Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. [PDF]
PLoS ONE, 2016 Pannexin1 (Panx1) subunits oligomerize to form large-pore channels between the intracellular and extracellular milieu that have been shown to regulate proliferation, differentiation and cell death mechanisms.
Michael K G Stewart +3 more
doaj +8 more sources
Astrocyte and Neuronal Panx1 Support Long-Term Reference Memory in Mice
ASN Neuro, 2023 Pannexin 1 (Panx1) is an ubiquitously expressed protein that forms plasma membrane channels permeable to anions and moderate-sized signaling molecules (e.g., ATP, glutamate).
Price Obot +7 more
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Mechanisms of Pannexin 1 (PANX1) Channel Mechanosensitivity and Its Pathological Roles [PDF]
International Journal of Molecular Sciences, 2022 Pannexins (PANX) were cloned based on their sequence homology to innexins (Inx), invertebrate gap junction proteins. Although there is no sequence homology between PANX and connexins (Cx), these proteins exhibit similar configurations.
Taolei Sun, Zhao Xinyue, Sun Taolei
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Cells, 2022 Pannexin1 (Panx1) is expressed in both neurons and glia where it forms ATP-permeable channels that are activated under pathological conditions such as epilepsy, migraine, inflammation, and ischemia.
Antonio Cibelli +2 more
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Stomatin inhibits pannexin-1-mediated whole-cell currents by interacting with its carboxyl terminal. [PDF]
PLoS ONE, 2012 The pannexin-1 (Panx1) channel (often referred to as the Panx1 hemichannel) is a large-conductance channel in the plasma membrane of many mammalian cells.
Haiying Zhan +9 more
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