Results 1 to 10 of about 2,722 (132)
HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]
FASEB JAutosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K +10 more
europepmc +2 more sources
Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport. [PDF]
Cancer SciSmall cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Tsuruda T, Kodama M, Nakayama KI.
europepmc +2 more sources
Investigation of olfactory function in a Panx1 knock out mouse model
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Valery Shestopalov +2 more
exaly +3 more sources
Cells, 2022 Pannexin1 (Panx1) is expressed in both neurons and glia where it forms ATP-permeable channels that are activated under pathological conditions such as epilepsy, migraine, inflammation, and ischemia.
Eliana Scemes +2 more
exaly +3 more sources
Prothrombotic Activation of Platelet Pannexin-1 Channels in Antiphospholipid Syndrome. [PDF]
Arthritis RheumatolObjective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
de Moraes Mazetto Fonseca B +13 more
europepmc +2 more sources
A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model
Frontiers in Molecular Neuroscience, 2018 Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Valery Shestopalov +2 more
exaly +3 more sources
The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent
ASN Neuro, 2021 Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes the reduction of epileptiform activity and ictal ...
Price Obot +3 more
doaj +1 more source
Oncogenesis, 2022 Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression.
Xiao Xiang +5 more
doaj +1 more source
The impact of Panx1 on inflammation, immunity, and cancer: a comprehensive review [PDF]
Frontiers in MedicineCARLOS Barrera-Avalos +2 more
exaly +2 more sources
Journal of Neuroinflammation, 2020 Background Neuroinflammation is a major component of secondary damage after traumatic brain injury (TBI). We recently reported that pharmacological inhibition of Pannexin-1 (Panx1) channels markedly reduced the inflammatory response after TBI.
Joon Ho Seo +3 more
doaj +1 more source