Results 1 to 10 of about 3,650 (196)

Investigation of olfactory function in a Panx1 knock out mouse model [PDF]

Frontiers in Cellular Neuroscience, 2014
Pannexin 1 (Panx1), the most extensively investigated member of a channel-forming protein family, is able to form pores conducting molecules up to 1.5 kDa, like ATP, upon activation.
Valery Shestopalov, Hanns Hatt, Stefan Kurtenbach   +2 more
exaly   +7 more sources

A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model [PDF]

Frontiers in Molecular Neuroscience, 2018
Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the role(s) of ...
Valery Shestopalov, Peter Carlen, Stefan Kurtenbach   +2 more
exaly   +7 more sources

The Contribution of Astrocyte and Neuronal Panx1 to Seizures Is Model and Brain Region Dependent [PDF]

ASN Neuro, 2021
Pannexin1 (Panx1) is an ATP release channel expressed in neurons and astrocytes that plays important roles in CNS physiology and pathology. Evidence for the involvement of Panx1 in seizures includes the reduction of epileptiform activity and ictal ...
Price Obot, Libor Velíšek, Jana Velíšková, Eliana Scemes   +3 more
doaj   +5 more sources

Activity and Stability of Panx1 Channels in Astrocytes and Neuroblastoma Cells Are Enhanced by Cholesterol Depletion

Cells, 2022
Pannexin1 (Panx1) is expressed in both neurons and glia where it forms ATP-permeable channels that are activated under pathological conditions such as epilepsy, migraine, inflammation, and ischemia.
David C Spray, Eliana Scemes, Antonio Cibelli   +2 more
exaly   +5 more sources

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +2 more sources

HIF-Regulated Pannexin-1 Channel Drives Luminal ATP Accumulation in Kidney Cysts. [PDF]

FASEB J
Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Skoczynski K, Scholz JK, Ursu R, Schödel J, Grampp S, Naas S, Lauer V, Schiffer M, Büttner-Herold M, Buchholz B, Kraus A.   +10 more
europepmc   +2 more sources

Discovery of membrane channel modulators via DNA encoded library screening using native like membrane protein nanoparticles [PDF]

Scientific Reports
Developing novel drugs against membrane proteins is a major challenge in drug discovery due to the difficulty of stabilizing these targets for high-throughput screenings.
Francesco V. Reddavide, Trine L. Toft-Bertelsen, Ieva Drulyte, Aspen Rene Gutgsell, Dzung Nguyen, Sara Bonetti, Katerina Vafia, Anne-Sophie Tournillon, Stephan Heiden, Daniel Grosser, Katarina Iric, Veronica Diez, Nanna MacAulay, Stefan Geschwindner, Michael Thompson, Jens Frauenfeld, Robin Löving   +16 more
doaj   +2 more sources

Quercetin induces pannexin 1 expression via an alternative transcript with a translationally active 5′ leader in rhabdomyosarcoma

Oncogenesis, 2022
Rhabdomyosarcoma (RMS) is a deadly cancer of skeletal muscle origin. Pannexin 1 (PANX1) is down-regulated in RMS and increasing its levels drastically inhibits RMS progression.
Xiao Xiang, Huy-Dung Hoang, Victoria H. Gilchrist, Stéphanie Langlois, Tommy Alain, Kyle N. Cowan   +5 more
doaj   +1 more source

Pannexin-1 Contributes to the Apoptosis of Spinal Neurocytes in Spinal Cord Injury

Frontiers in Physiology, 2021
Currently, the role of Pannexin-1, a homomeric membrane hemichannel on the neuron cell membrane, in the development of spinal cord injury (SCI) is largely unknown. Herein, we assessed the contribution of Panx1 in the development of SCI.
Yu Huang, Jin Lin, Xuanwei Chen, Jianhua Lin   +3 more
doaj   +1 more source

Myeloid Pannexin-1 mediates acute leukocyte infiltration and leads to worse outcomes after brain trauma

Journal of Neuroinflammation, 2020
Background Neuroinflammation is a major component of secondary damage after traumatic brain injury (TBI). We recently reported that pharmacological inhibition of Pannexin-1 (Panx1) channels markedly reduced the inflammatory response after TBI.
Joon Ho Seo, Miloni S. Dalal, Frances Calderon, Jorge E. Contreras   +3 more
doaj   +1 more source