Results 41 to 50 of about 3,413 (197)
Pannexin1 channels—a potential therapeutic target in inflammation
Frontiers in Cell and Developmental Biology, 2022 An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a central signaling molecule that orchestrates the initiation and resolution of the inflammatory response by enhancing activation of the inflammasome, leukocyte ...
Olga M. Rusiecka +7 more
doaj +1 more source
Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton
Frontiers in Physiology, 2014 Pannexin 1 (Panx1) large-pore ion and metabolite channels are emerging as key proteins in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component ...
Andrew Kenneth Jameson Boyce +5 more
doaj +1 more source
Stomatin coimmunoprecipitated with Panx1.
, 2013 HA-tagged stomatin (Stomatin::HA) was coexpressed with Myc-tagged Panx1 (Panx1::Myc) of either the full-length or a fragment in HEK-293T cells. A. Diagram of Panx1 membrane topology.
Zhao-Wen Wang (317498) +9 more
core +1 more source
Molecular pathways of pannexin1-mediated neurotoxicity
Frontiers in Physiology, 2014 Pannexin1 (Panx1) forms nonselective membrane channels, structurally similar to gap junction hemichannels, that is permeable to ions, nucleotides and other small molecules below 900 Da. Panx1 activity is implicated in paracrine signaling and inflammasome
Valery I. Shestopalov +4 more
doaj +1 more source
Analysis of Panx1 ablation in CMV-cre/Panx1 (KO) mouse retinas.
, 2012 A. RT-PCR analysis of retinal and brain homogenates from wild type (WT), Panx1 CKO (CKO) and Panx1 KO (KO) mice using primers for the floxed Exon 4 (287 bp band, arrow). B.
Vladlen Z. Slepak (113409) +6 more
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Panx1 is dynamically regulated in the mammary gland and ablated in Panx1-/- mice.
, 2016 (A) Western blot analysis revealed that Panx1 is upregulated following the onset of pregnancy and remains elevated throughout lactation. Multiple bands on the western blot represent various Panx1 species due to changes in glycosylation (Gly0, Gly1 and ...
Dale W. Laird (591712) +3 more
core +1 more source
Increased Panx1 channel activity in EAE.
, 2013 (A) Bar histograms of the mean ± s.e.m. values of the relative intensity of YoPro uptake (test/control) recorded from Panx1 wild type (WT) and Panx1 knockout (KO) spinal cord slices of control and EAE mice ...
Sylvia O. Suadicani (424633) +10 more
core +1 more source
Characterization of Panx1−/− mice.
, 2012 a, RT-PCR and western blot analysis of 4 adult Panx1+/+ control and Panx1−/− animals. Note the lack of the 287 bp PCR amplicon representing the deleted exon4 in the Panx1 mRNA and the loss of the Panx1 protein in Panx1−/− mice.
Stefan Kurtenbach (108906) +10 more
core +1 more source
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
Delayed onset of EAE in Panx1 KO mice.
, 2013 (A - right) Time course of clinical signs recorded from Panx1 wild type (WT) and Panx1 knockout (KO) mice immunized for MOG. (A-left) The graph depicts the initial acute phase of the disease (blue rectangle in A) showing that up to day 12 post ...
Sylvia O. Suadicani (424633) +10 more
core +1 more source