Results 1 to 10 of about 1,892 (187)

Are there gap junctions without connexins or pannexins?

BMC Evolutionary Biology, 2019
Background Gap junctions (GJ) are one of the most common forms of intercellular communication. GJs are assembled from proteins that form channels connecting the cytoplasm of adjacent cells.
VÍCTOR P Kuznetsov
exaly   +4 more sources

Intercellular Communication in Airway Epithelial Cell Regeneration: Potential Roles of Connexins and Pannexins [PDF]

International Journal of Molecular Sciences, 2023
Connexins and pannexins are transmembrane proteins that can form direct (gap junctions) or indirect (connexons, pannexons) intercellular communication channels. By propagating ions, metabolites, sugars, nucleotides, miRNAs, and/or second messengers, they
Mehdi Badaoui, Marc Chanson, Chanson Marc   +2 more
exaly   +3 more sources

Pannexins Are Potential New Players in the Regulation of Cerebral Homeostasis during Sleep-Wake Cycle

Frontiers in Cellular Neuroscience, 2017
During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells.
Valery I Shestopalov, Yuri Panchin, O S Tarasova   +2 more
exaly   +4 more sources

ATP-release pannexin channels are gated by lysophospholipids [PDF]

eLife
In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze, Russell N Burkhardt, Bennett William Fox, Tyler J Schwertfeger, Eric Gelsleichter, Kevin Michalski, Lydia Kramer, Margret Lenfest, Jordyn M Boesch, Hening Lin, Frank C Schroeder, Toshimitsu Kawate   +11 more
doaj   +2 more sources

Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate [PDF]

Scientific Reports
Membrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of ...
Makoto Hosoya, Satoshi Suda, Masafumi Ueno, Marie N. Shimanuki, Takanori Nishiyama, Naoki Oishi, Hiroyuki Ozawa   +6 more
doaj   +2 more sources

Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells [PDF]

Frontiers in Neuroscience, 2023
IntroductionThe subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals.
Enrique Jiménez-Madrona, Enrique Jiménez-Madrona, Camilo J. Morado-Díaz, Rocío Talaverón, Rocío Talaverón, Arantxa Tabernero, Angel M. Pastor, Juan C. Sáez, Esperanza R. Matarredona   +8 more
doaj   +2 more sources

Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]

Nature Communications
Pannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain, Ashish Apotikar, Shabareesh Pidathala, Sourajit Mukherjee, Ananth Prasad Burada, Sujit Kumar Sikdar, Kutti R. Vinothkumar, Aravind Penmatsa   +7 more
doaj   +2 more sources

Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury [PDF]

Biomedicines, 2022
Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or ...
Alice McDouall, Kelly Q. Zhou, Laura Bennet, Colin R. Green, Alistair J. Gunn, Joanne O. Davidson   +5 more
doaj   +2 more sources

Role of astrocytes connexins - pannexins in acute brain injury [PDF]

Neurotherapeutics
Acute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where some mechanisms show common determinants.
Juan E. Tichauer, Maximiliano Rovegno
doaj   +2 more sources

Pannexin 1 Regulates Skeletal Muscle Regeneration by Promoting Bleb-Based Myoblast Migration and Fusion Through a Novel Lipid Based Signaling Mechanism

Frontiers in Cell and Developmental Biology, 2021
Adult skeletal muscle has robust regenerative capabilities due to the presence of a resident stem cell population called satellite cells. Muscle injury leads to these normally quiescent cells becoming molecularly and metabolically activated and embarking
Katia Suarez-Berumen, Katia Suarez-Berumen, Henry Collins-Hooper, Anastasia Gromova, Anastasia Gromova, Robyn Meech, Alessandra Sacco, Phil R. Dash, Robert Mitchell, Valery I. Shestopalov, Valery I. Shestopalov, Thomas E. Woolley, Sakthivel Vaiyapuri, Ketan Patel, Helen P. Makarenkova   +14 more
doaj   +1 more source