Results 1 to 10 of about 1,937 (148)
Are there gap junctions without connexins or pannexins?
BMC Evolutionary Biology, 2019 Background Gap junctions (GJ) are one of the most common forms of intercellular communication. GJs are assembled from proteins that form channels connecting the cytoplasm of adjacent cells.
Víctor Kuznetsov
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The pannexins: past and present
Frontiers in Physiology, 2014 The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Stephen Bond, Christian Naus
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Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
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Frontiers in Cellular Neuroscience, 2017 During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells.
Dina Gaynullina +2 more
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Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells [PDF]
Frontiers in Neuroscience, 2023 IntroductionThe subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals.
Enrique Jiménez-Madrona +8 more
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Roles of gap junctions, connexins, and pannexins in epilepsy
Frontiers in Physiology, 2014 Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are ...
Peter Carlen
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Frontiers in Cell and Developmental Biology, 2021 Adult skeletal muscle has robust regenerative capabilities due to the presence of a resident stem cell population called satellite cells. Muscle injury leads to these normally quiescent cells becoming molecularly and metabolically activated and embarking
Katia Suarez-Berumen +14 more
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A review of the current state of pannexin channels as they relate to the blood vessel wall
Journal of Medical Sciences, 2017 Pannexin proteins comprise a family of channels whose sole function, to date, is the release of nucleotides (e.g., adenosine 5'-triphosphate [ATP] and uridine 5′-triphosphate [UTP]).
Brant E Isakson
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The emerging Pannexin 1 signalome: a new nexus revealed?
Frontiers in Cellular Neuroscience, 2014 Pannexins (Panxs) are a family of single-membrane, large-pore ion and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many ...
Leigh Elizabeth Wicki-Stordeur +4 more
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Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling
Function, 2022 The epidermis forms an essential barrier against a variety of insults. The overall goal of this study was to shed light not only on the effects of accidental epidermal injury, but also on the mechanisms that support laser skin resurfacing with intra ...
Viola Donati +8 more
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