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The pannexins: past and present [PDF]
Frontiers in Physiology, 2014 The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Stephen Bond +2 more
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ATP-release pannexin channels are gated by lysophospholipids [PDF]
eLifeIn addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze +11 more
doaj +2 more sources
Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate [PDF]
Scientific ReportsMembrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of ...
Makoto Hosoya +6 more
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Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells [PDF]
Frontiers in Neuroscience, 2023 IntroductionThe subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals.
Enrique Jiménez-Madrona +8 more
doaj +2 more sources
Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]
Nature CommunicationsPannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain +7 more
doaj +2 more sources
Frontiers in Cellular Neuroscience, 2017 During brain homeostasis, both neurons and astroglia release ATP that is rapidly converted to adenosine in the extracellular space. Pannexin-1 (Panx1) hemichannels represent a major conduit of non-vesicular ATP release from brain cells.
Dina Gaynullina +2 more
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Are there gap junctions without connexins or pannexins?
BMC Evolutionary Biology, 2019 Background Gap junctions (GJ) are one of the most common forms of intercellular communication. GJs are assembled from proteins that form channels connecting the cytoplasm of adjacent cells.
VÍCTOR Kuznetsov
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Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury [PDF]
Biomedicines, 2022 Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or ...
Alice McDouall +5 more
doaj +2 more sources
Role of astrocytes connexins - pannexins in acute brain injury [PDF]
NeurotherapeuticsAcute brain injuries (ABIs) encompass a broad spectrum of primary injuries such as ischemia, hypoxia, trauma, and hemorrhage that converge into secondary injury where some mechanisms show common determinants.
Juan E. Tichauer, Maximiliano Rovegno
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Roles of gap junctions, connexins, and pannexins in epilepsy
Frontiers in Physiology, 2014 Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are ...
Peter Carlen, Carlen Peter L
exaly +3 more sources