Results 11 to 20 of about 1,563 (163)
Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
doaj +3 more sources
The Role of Pannexin Hemichannels in Inflammation and Regeneration [PDF]
Frontiers in Physiology, 2014 Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue regeneration.
Helen P. Makarenkova +2 more
doaj +3 more sources
Intercellular Communication in Airway Epithelial Cell Regeneration: Potential Roles of Connexins and Pannexins [PDF]
International Journal of Molecular Sciences, 2023 Marc Chanson +2 more
exaly +2 more sources
Connexins, Pannexins, and Epilepsy
Abstract Connexins are proteins that form gap junctions which “connect” cells together, permitting the passage of small molecules and electricity. Since epilepsy is thought of as a disease of neuronal hypersynchrony, it is natural to consider these molecules with the gap junctions they form as playing a significant role in epilepsy ...
Zhang L, Zoidl GR, Carlen PL.
exaly +3 more sources
Emerging functions of Pannexin 1 in the eye [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +3 more sources
Pharmacology of pannexin channels. [PDF]
Curr Opin Pharmacol, 2023 Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Koval M, Schug WJ, Isakson BE.
europepmc +3 more sources
Pannexins in the vasculature. [PDF]
Am J Physiol Heart Circ PhysiolPannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardiovascular system and is the most highly studied pannexin in both homeostatic and disease conditions.
O'Donnell BL +6 more
europepmc +4 more sources
Pannexin channels in the kidney. [PDF]
Am J Physiol Renal PhysiolRenal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD +5 more
europepmc +3 more sources
Channel plan: control of adaptive immune responses by pannexins [PDF]
Trends in ImmunologyMasaki Ishikawa +1 more
exaly +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Adult skeletal muscle has robust regenerative capabilities due to the presence of a resident stem cell population called satellite cells. Muscle injury leads to these normally quiescent cells becoming molecularly and metabolically activated and embarking
Katia Suarez-Berumen +14 more
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