Results 11 to 20 of about 1,892 (187)
Identification of Pannexins in Rat Nasal Mucosa
Allergy & Rhinology, 2013 Pannexins are a second family of gap-junction proteins in vertebrates, classified as pannexin-1, pannexin-2, and pannexin-3. Pannexin-1 is one of the candidates for channel-mediated ATP release into the extracellular space.
Toyoaki Ohbuchi M.D. +7 more
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The Pannexins: Past and Present [PDF]
Frontiers in Physiology, 2014 The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and Panx3) are shared among the major vertebrate phyla, but they appear to ...
Steven eBond +2 more
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Human stem cells express pannexins
BMC Research Notes, 2018 Objective Pannexins are channel proteins important for the release of calcium and adenosine triphosphate, which are among other functions involved in early development.
Nadine Hainz +6 more
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Connexins and pannexins in liver damage [PDF]
EXCLI journal, 2016 EXCLI Journal;Vol.
Crespo Yanguas, Sara +7 more
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Lymphatic Connexins and Pannexins in Health and Disease [PDF]
International Journal of Molecular Sciences, 2021 This review highlights current knowledge on the expression and function of connexins and pannexins, transmembrane channel proteins that play an important role in intercellular communication, in both the developing and mature lymphatic vasculature. A particular focus is given to the involvement of these proteins in functions of the healthy lymphatic ...
Avigail Ehrlich +3 more
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Pannexins in ischemia-induced neurodegeneration [PDF]
Proceedings of the National Academy of Sciences, 2011 Pannexin 1 (Px1, Panx1) and pannexin 2 (Px2, Panx2) form large-pore nonselective channels in the plasma membrane of cells and were suggested to play a role in the pathophysiology of cerebral ischemia. To directly test a potential contribution of pannexins in ischemia-related mechanisms, we performed experiments in
Bargiotas, Panagiotis +9 more
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Connexins and Pannexins in Vascular Function and Disease [PDF]
International Journal of Molecular Sciences, 2018 Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication ...
Filippo Molica +4 more
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The Role of Pannexin Hemichannels in Inflammation and Regeneration [PDF]
Frontiers in Physiology, 2014 Tissue injury involves coordinated systemic responses including inflammatory response, targeted cell migration, cell-cell communication, stem cell activation and proliferation, and tissue regeneration.
Helen P. Makarenkova +2 more
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Connexins and pannexins: New insights into microglial functions and dysfunctions
Frontiers in Molecular Neuroscience, 2016 In a physiological context, microglia adopt a resting phenotype that is associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, they shift to the activated phenotype that is necessary for ...
Rosario Gajardo-Gómez +2 more
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Connexins and pannexins: from biology towards clinical targets
Swiss Medical Weekly, 2016 Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the ...
Paolo Meda, Jacques-Antoine Haefliger
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