Results 11 to 20 of about 1,937 (148)
Human stem cells express pannexins
BMC Research Notes, 2018 Objective Pannexins are channel proteins important for the release of calcium and adenosine triphosphate, which are among other functions involved in early development.
Nadine Hainz +6 more
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ATP-release pannexin channels are gated by lysophospholipids [PDF]
eLifeIn addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication.
Erik Henze +11 more
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Expression of connexins and pannexins in diseased human liver
EXCLI Journal : Experimental and Clinical Sciences, 2022 Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy +8 more
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Distinct Connexin43, Connexin31, and Pannexin1 expression patterns in the cochlea of a non-human primate [PDF]
Scientific ReportsMembrane channels play an important role in auditory processes. Connexins and pannexins are membrane channels that exist in the cochlea. Connexin26 and connexin30 have been previously shown to be differentially expressed in the developing cochlea of ...
Makoto Hosoya +6 more
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Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms [PDF]
Nature CommunicationsPannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse cellular roles and differ in their pore lining residues.
Nazia Hussain +7 more
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Connexins, Pannexins and Gap Junctions in Perinatal Brain Injury [PDF]
Biomedicines, 2022 Perinatal brain injury secondary to hypoxia-ischemia and/or infection/inflammation remains a major cause of disability. Therapeutic hypothermia significantly improves outcomes, but in randomized controlled trials nearly half of infants still died or ...
Alice McDouall +5 more
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When can AlphaFold predict the oligomeric states of proteins? [PDF]
Protein Science, Volume 35, Issue 7, July 2026.Abstract Homooligomerisation is a prevalent and important process that many proteins undergo to form the quaternary structures required for biological function. However, determining oligomeric states and structures experimentally remains technically challenging and time‐consuming for many proteins.
Yiechang Lin, Ciara Wallis, Ben Corry
wiley +2 more sources
The two faces of pannexins: new roles in inflammation and repair [PDF]
Journal of Inflammation Research, 2018 Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
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Connexins and pannexins: New insights into microglial functions and dysfunctions [PDF]
Frontiers in Molecular Neuroscience, 2016 In a physiological context, microglia adopt a resting phenotype that is associated with the production of anti-inflammatory and neurotrophic factors. In response to a wide variety of insults, they shift to the activated phenotype that is necessary for ...
Rosario Gajardo-Gómez +2 more
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Mind the gap: connexins and pannexins in platelet function [PDF]
Platelets, 2021 Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Kirk a Taylor +2 more
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