Results 21 to 30 of about 1,892 (187)
The two faces of pannexins: new roles in inflammation and repair [PDF]
Journal of Inflammation Research, 2018 Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs ...
Makarenkova HP, Shah SB, Shestopalov VI
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Connexins, Pannexins, and Epilepsy
Abstract Connexins are proteins that form gap junctions which “connect” cells together, permitting the passage of small molecules and electricity. Since epilepsy is thought of as a disease of neuronal hypersynchrony, it is natural to consider these molecules with the gap junctions they form as playing a significant role in epilepsy ...
Zhang L, Zoidl GR, Carlen PL.
exaly +3 more sources
Mind the gap: connexins and pannexins in platelet function [PDF]
Platelets, 2021 Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Kirk a Taylor +2 more
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Emerging functions of Pannexin 1 in the eye [PDF]
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
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Pharmacology of pannexin channels. [PDF]
Curr Opin Pharmacol, 2023 Pannexin channels play fundamental roles in regulating inflammation and have been implicated in many diseases including hypertension, stroke, and neuropathic pain. Thus, the ability to pharmacologically block these channels is a vital component of several therapeutic approaches.
Koval M, Schug WJ, Isakson BE.
europepmc +3 more sources
Pannexins in the vasculature. [PDF]
Am J Physiol Heart Circ PhysiolPannexins (PANX1, PANX2, PANX3) are a family of large-pore, ion and metabolite channels present throughout the blood and lymphatic vascular networks. PANX1 has near-ubiquitous expression in the cardiovascular system and is the most highly studied pannexin in both homeostatic and disease conditions.
O'Donnell BL +6 more
europepmc +4 more sources
Pannexin channels in the kidney. [PDF]
Am J Physiol Renal PhysiolRenal dysfunction leads to critical health conditions, including acute kidney injury (AKI) and chronic kidney disease (CKD), and is a driver of hypertension. Despite their global prevalence and impact, the pathophysiology for all kidney disease subtypes is incompletely understood; therefore, many patients progress to kidney failure, needing dialysis ...
Williams MD +5 more
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Pannexin: To gap or not to gap, is that a question?
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2006 Vertebrates express two families of gap junction proteins: the well characterized connexins and the recently discovered pannexins. The latter are related to invertebrate innexins. Here we present the hypothesis that pannexins, rather than providing a redundant system to gap junctions formed by connexins, exert a physiological role as nonjunctional ...
Gerhard, Dahl, Silviu, Locovei
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Role of pannexins in vasculature [PDF]
, 2017 Pannexins are newly discovered proteins that were first discovered by Panchin in 2000. The pannexin family has three isomers, i.e. pannexin-1, pannexin-2, and pannexin-3. In 2011, Billaud et al suggested that pannexin1 channels contribute to the spread of vasoconstriction after activation of α1D-adrenoceptors present on the surface of vascular smooth ...
Habib, Alaa
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