Results 41 to 50 of about 1,892 (187)

Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet

Frontiers in Cellular Neuroscience, 2014
Nicotine, the most important neuroteratogen of tobacco smoke, can reproduce brain and cognitive disturbances per se when administered prenatally. However, it is still unknown if paracrine signaling among brain cells participates in prenatal nicotine ...
Juan Andrés Orellana, Dolores eBusso, Gigliola eRamirez, Marlys eCampos, Attilio eRigotti, Jaime eEugenin, Rommy eVon Bernhardi   +6 more
doaj   +1 more source

Expression of connexins and pannexins in diseased human liver

EXCLI Journal : Experimental and Clinical Sciences, 2022
Connexin proteins can form hexameric hemichannels and gap junctions that mediate paracrine and direct intercellular communication, respectively. Gap junction activity is crucial for the maintenance of hepatic homeostasis, while connexin hemichannels ...
Kaat Leroy, Vânia Vilas-Boas, Eva Gijbels, Bart Vanderborght, Lindsey Devisscher, Bruno Cogliati, Bert Van Den Bossche, Isabelle Colle, Mathieu Vinken   +8 more
doaj   +1 more source

Pannexin channels and ischaemia [PDF]

The Journal of Physiology, 2014
AbstractAn ischaemic stroke occurs during loss of blood flow in the brain from the occlusion of a blood vessel. The ischaemia itself comprises a complex array of insults, including oxygen and glucose deprivation (OGD), glutamate excitotoxicity, acidification/hypercapnia, and loss of sheer forces.
openaire   +2 more sources

Control of the neurovascular coupling by nitric oxide-dependent regulation of astrocytic Ca2+ signaling

Frontiers in Cellular Neuroscience, 2015
Neuronal activity must be tightly coordinated with blood flow to keep proper brain function, which is achieved by a mechanism known as neurovascular coupling. Then, an increase in synaptic activity leads to a dilation of local parenchymal arterioles that
Manuel Francisco Muñoz, Mariela ePuebla, Xavier eFigueroa   +2 more
doaj   +1 more source

Connexin and pannexin channels in cancer [PDF]

BMC Cell Biology, 2016
Communication among cells via direct cell-cell contact by connexin gap junctions, or between cell and extracellular environment via pannexin channels or connexin hemichannels, is a key factor in cell function and tissue homeostasis. Upon malignant transformation in different cancer types, the dysregulation of these connexin and pannexin channels and ...
Jiang, Jean X., Penuela, Silvia
openaire   +4 more sources

Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence

, 2021
The oocyte is the major determinant of embryo developmental competence in all mammalian species. Although fundamental advances have been generated in the field of reproductive medicine and assisted reproductive technologies in the past three decades ...
Mariusz T. Skowronski, Paweł Kordowitzki, Agnieszka Skowronska, Marta Wasielak-Politowska, Gabriela Sokołowska   +4 more
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Restraint stress increases hemichannel activity in hippocampal glial cells and neurons

Frontiers in Cellular Neuroscience, 2015
Stress affects brain areas involved in learning and emotional responses, which may contribute in the development of cognitive deficits associated with major depression.
Juan Andrés Orellana, Rodrigo eMoraga-Amaro, Raúl eDíaz-Galarce, sebastian eRojas, Carola J Maturana, Jimmy eStehberg, Juan C Saez   +6 more
doaj   +1 more source

Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

Communications Biology, 2022
The Panx1a and Panx1b (pannexin) ATP release channels exhibit pro- and anti-convulsant effects, respectively, in a zebrafish model, providing further insight into the role of pannexins in seizure development.
Paige Whyte-Fagundes, Daria Taskina, Nickie Safarian, Christiane Zoidl, Peter L. Carlen, Logan W. Donaldson, Georg R. Zoidl   +6 more
doaj   +1 more source

Functional implications of calcium permeability of the channel formed by pannexin 1. [PDF]

, 2006
Although human pannexins (PanX) are homologous to gap junction molecules, their physiological function in vertebrates remains poorly understood. Our results demonstrate that overexpression of PanX1 results in the formation of Ca(2+)-permeable gap ...
Ivanov, Dmitry, V, Panchin, YV, Vanden Abeele, F, Fabien Vanden Abeele, Panchin, Yuri V, Gordienko, D, Yuri V. Panchin, Baranova, AV, Skryma, R, Baranova, Ancha, V, Skryma, Roman, Gordienko, Dmitri, Gabriel Bidaux, Beck, Benjamin, Ivanov, DV, Prevarskaya, N, Ancha V. Baranova, Baranova, Ancha V, Natalia Prevarskaya, Benjamin Beck, Ivanov, Dmitry V, Panchin, Yuri, Ivanov, Dimitri, Prevarskaya, Natalia, Vanden Abeele, Fabien, Bidaux, G, Bidaux, Gabriel, Dmitry V. Ivanov, Beck, B, Panchin, Yuri, V, Roman Skryma, Dmitri Gordienko   +31 more
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Anti-parasitic drugs modulate the non-selective channels formed by connexins or pannexins

, 2021
The proteins connexins, innexins, and pannexins are the subunits of non-selective channels present in the cell membrane in vertebrates (connexins and pannexins) and invertebrates (innexins).
Gutiérrez, Camila, Sáez, Juan C., Güiza, Juan, Rodríguez, Luis, Vega, José L., Duarte, Yorley, Arriagada, Javiera   +6 more
core   +1 more source