Results 41 to 50 of about 1,937 (148)
Connexins and pannexins in neuronal development and adult neurogenesis [PDF]
, 2016 Connexins and pannexins share very similar structures and functions; they also exhibit overlapping expression in many stages of neuronal development. Here, we review evidence implicating connexin- and pannexin-mediated communication in the regulation of ...
Swayne, Leigh A +3 more
core +2 more sources
Biomolecules, 2023 Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS).
Giuseppe Caruso +2 more
doaj +1 more source
The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition
eLife, 2020 Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski +5 more
doaj +1 more source
Interplay of Connexins and Pannexins in Tissue Function and Disease [PDF]
, 2018 This Special Issue is related to the 18th biannual International Gap Junction Conference (IGJC2017), which has been held at the Crowne Plaza Hotel, Glasgow and hosted by Glasgow Caledonian University, 29 July–3 August, 2017. This Special Issue, entitled “
Patricia Martin (Ed.) +1 more
core +1 more source
The Neuroglial Dialog Between Cannabinoids and Hemichannels
Frontiers in Molecular Neuroscience, 2018 The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules ...
Valeria C. Labra +11 more
doaj +1 more source
Emerging functions of Pannexin 1 in the eye
Frontiers in Cellular Neuroscience, 2014 Pannexin 1 (Panx1) is a high-conductance, voltage-gated channel protein found in vertebrates. It has been shown that Panx1 is widely expressed in many organs and tissues, including sensory systems.
Sarah eKurtenbach +2 more
doaj +1 more source
Epilepsia, EarlyView.Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer +7 more
wiley +1 more source
Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury
Frontiers in Molecular Neuroscience, 2019 Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial activation and neuroinflammation in the retina. Glial activation and release of pro-inflammatory cytokines TNFα and IL-1β, complement, and other danger factors was ...
Alexey Pronin +11 more
doaj +1 more source
The FEBS Journal, EarlyView.Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester +11 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2018 A mounting body of evidence indicates that adolescents are specially more susceptible to alcohol influence than adults. However, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez +13 more
doaj +1 more source