Results 41 to 50 of about 1,563 (163)

The cellular life of pannexins [PDF]

Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012
AbstractThe mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2, and Panx3 has received considerable attention in the last 10 years given their newly discovered physiological roles in development and disease. Pannexins exhibit diverse subcellular profiles indicating that they may serve distinct roles in cells and tissues of
Silvia Penuela, Dale W. Laird
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Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases

Frontiers in Cellular Neuroscience, 2019
A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter composition of the extracellular ...
Lucila Brocardo, Luis Ernesto Acosta, Ana Paula Piantanida, Lorena Rela   +3 more
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Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function

Frontiers in Molecular Neuroscience, 2017
Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Veronica Zorzi, Veronica Zorzi, Fabiola Paciello, Gaia Ziraldo, Gaia Ziraldo, Chiara Peres, Flavia Mazzarda, Flavia Mazzarda, Chiara Nardin, Chiara Nardin, Miriam Pasquini, Miriam Pasquini, Francesco Chiani, Marcello Raspa, Ferdinando Scavizzi, Andrea Carrer, Giulia Crispino, Catalin D. Ciubotaru, Hannah Monyer, Anna R. Fetoni, Anna M. Salvatore, Fabio Mammano, Fabio Mammano, Fabio Mammano   +23 more
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Promises and pitfalls of a Pannexin1 transgenic mouse line.

Frontiers in Pharmacology, 2013
Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a knockout at the RNA processing level and also allows for the generation of conditional KO ...
Regina eHanstein, Hiromitsu eNegoro, Naman K. Patel, Anne eCharollais, Paolo eMeda, David C. Spray, Sylvia O. Suadicani, Eliana eScemes   +7 more
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Innexin and pannexin channels and their signaling [PDF]

FEBS Letters, 2014
Innexins are bifunctional membrane proteins in invertebrates, forming gap junctions as well as non‐junctional membrane channels (innexons). Their vertebrate analogues, the pannexins, have not only lost the ability to form gap junctions but are also prevented from it by glycosylation.
Dahl, Gerhard, Muller, Kenneth J.
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Gap Junctions and Connexins in Microglia-Related Oxidative Stress and Neuroinflammation: Perspectives for Drug Discovery

Biomolecules, 2023
Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS).
Giuseppe Caruso, Lucia Di Pietro, Filippo Caraci   +2 more
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N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1 [PDF]

International Journal of Molecular Sciences, 2018
Pannexins (Panx1, 2, 3) are channel-forming glycoproteins expressed in mammalian tissues. We previously reported that N-glycosylation acts as a regulator of the localization and intermixing of Panx1 and Panx3, but its effects on Panx2 are currently unknown.
Rafael E. Sanchez-Pupo, Danielle Johnston, Silvia Penuela   +2 more
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The Neuroglial Dialog Between Cannabinoids and Hemichannels

Frontiers in Molecular Neuroscience, 2018
The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules ...
Valeria C. Labra, Valeria C. Labra, Cristian A. Santibáñez, Cristian A. Santibáñez, Rosario Gajardo-Gómez, Rosario Gajardo-Gómez, Esteban F. Díaz, Esteban F. Díaz, Gonzalo I. Gómez, Gonzalo I. Gómez, Juan A. Orellana, Juan A. Orellana   +11 more
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The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition

eLife, 2020
Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski, Johanna L Syrjanen, Erik Henze, Julia Kumpf, Hiro Furukawa, Toshimitsu Kawate   +5 more
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Connexins and Pannexins in cerebral ischemia

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018
A common cause of mortality and long-term adult disability, cerebral ischemia or brain ischemia imposes a significant health and financial burden on communities worldwide. Cerebral ischemia is a condition that arises from a sudden loss of blood flow and consequent failure to meet the high metabolic demands of the brain. The lack of blood flow initiates
Yeri Kim, Joanne O. Davidson, Colin R. Green, Louise F.B. Nicholson, Simon J. O'Carroll, Jie Zhang   +5 more
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