Results 51 to 60 of about 1,563 (163)
Epilepsia, EarlyView.Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer +7 more
wiley +1 more source
Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury
Frontiers in Molecular Neuroscience, 2019 Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial activation and neuroinflammation in the retina. Glial activation and release of pro-inflammatory cytokines TNFα and IL-1β, complement, and other danger factors was ...
Alexey Pronin +11 more
doaj +1 more source
The FEBS Journal, EarlyView.Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester +11 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2018 A mounting body of evidence indicates that adolescents are specially more susceptible to alcohol influence than adults. However, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez +13 more
doaj +1 more source
Mechanisms of SARS-CoV-2 and Male Infertility: Could Connexin and Pannexin Play a Role?
Frontiers in Physiology, 2022 The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on male infertility has lately received significant attention. SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) in humans, has been shown to impose adverse effects
Temidayo S. Omolaoye +4 more
doaj +1 more source
Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling
Journal of Periodontal Research, EarlyView.Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon +4 more
wiley +1 more source
Connexins, Innexins, and Pannexins: From Biology to Clinical Targets
Biomolecules, 2021 In 1964, Loewenstein and Kanno [...]
Trond Aasen
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Possible role of hemichannels in cancer.
Frontiers in Physiology, 2014 In humans, connexins (Cxs) and pannexins (Panxs) are the building blocks of hemichannels. These proteins are frequently altered in neoplastic cells and have traditionally been considered as tumor suppressors.
Kurt Alex Schalper +3 more
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Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source