Results 51 to 60 of about 1,892 (187)
Frontiers in Cellular Neuroscience, 2021 Electrical synaptic transmission is an essential form of interneuronal communication which is mediated by gap junctions that permit ion flow. Three gene families (connexins, innexins, and pannexins) have evolved to form gap junctional channels.
Qiqian Wang, Shenquan Liu
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Posttranslational Modifications in Connexins and Pannexins [PDF]
The Journal of Membrane Biology, 2012 Posttranslational modification is a common cellular process that is used by cells to ensure a particular protein function. This can happen in a variety of ways, e.g., from the addition of phosphates or sugar residues to a particular amino acid, ensuring proper protein life cycle and function.
Scott R, Johnstone +4 more
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Interplay of Connexins and Pannexins in Tissue Function and Disease [PDF]
, 2018 This Special Issue is related to the 18th biannual International Gap Junction Conference (IGJC2017), which has been held at the Crowne Plaza Hotel, Glasgow and hosted by Glasgow Caledonian University, 29 July–3 August, 2017. This Special Issue, entitled “
Patricia Martin (Ed.) +1 more
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Frontiers in Cellular Neuroscience, 2019 A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter composition of the extracellular ...
Lucila Brocardo +3 more
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Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function
Frontiers in Molecular Neuroscience, 2017 Panx1 forms plasma membrane channels in brain and several other organs, including the inner ear. Biophysical properties, activation mechanisms and modulators of Panx1 channels have been characterized in detail, however the impact of Panx1 on auditory ...
Veronica Zorzi +23 more
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Pannexins and gap junction protein diversity
, 2008 Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ formation. Another family of GJ proteins (innexins) were first found in
Shestopalov, V I, Panchin, Y
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The cellular life of pannexins [PDF]
Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 2012 AbstractThe mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2, and Panx3 has received considerable attention in the last 10 years given their newly discovered physiological roles in development and disease. Pannexins exhibit diverse subcellular profiles indicating that they may serve distinct roles in cells and tissues of
Silvia Penuela, Dale W. Laird
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Promises and pitfalls of a Pannexin1 transgenic mouse line.
Frontiers in Pharmacology, 2013 Gene targeting strategies have become a powerful technology for elucidating mammalian gene function. The recently generated knockout (KO)-first strategy produces a knockout at the RNA processing level and also allows for the generation of conditional KO ...
Regina eHanstein +7 more
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Innexin and pannexin channels and their signaling [PDF]
FEBS Letters, 2014 Innexins are bifunctional membrane proteins in invertebrates, forming gap junctions as well as non‐junctional membrane channels (innexons). Their vertebrate analogues, the pannexins, have not only lost the ability to form gap junctions but are also prevented from it by glycosylation.
Dahl, Gerhard, Muller, Kenneth J.
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Biomolecules, 2023 Microglia represent the immune system of the brain. Their role is central in two phenomena, neuroinflammation and oxidative stress, which are at the roots of different pathologies related to the central nervous system (CNS).
Giuseppe Caruso +2 more
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