Results 71 to 80 of about 1,937 (148)
Glia, Volume 74, Issue 7, July 2026.Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat +3 more
wiley +1 more source
Connexins and pannexins: important players in tumorigenesis, metastasis and potential therapeutics [PDF]
, 2018 Since their characterization more than five decades ago, gap junctions and their structural proteins—the connexins—have been associated with cancer cell growth.
Jiang, Jean +9 more
core +1 more source
MedComm, Volume 7, Issue 7, July 2026.Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru +18 more
wiley +1 more source
A quantized mechanism for activation of pannexin channels
Nature Communications, 2017 Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance
Yu-Hsin Chiu +10 more
doaj +1 more source
Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease
Frontiers in Cellular Neuroscience, 2019 Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar +7 more
doaj +1 more source
Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra +7 more
wiley +1 more source
Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling
Journal of Periodontal Research, Volume 61, Issue 6, Page 662-694, June 2026.Periodontitis can be viewed as a state of inflammatory uncoupling of bone remodeling, in which excessive osteoclast‐mediated resorption coexists with impaired bone formation. This review integrates emerging insights from osteoimmunology, osteocyte biology, mechanobiology, aging, and resolution pathways to position periodontitis as an accessible in vivo
Rafael Scaf de Molon +4 more
wiley +1 more source
The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source
HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski +10 more
wiley +1 more source
Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases
Frontiers in Physiology, 2014 In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez +3 more
doaj +1 more source