Results 61 to 70 of about 1,563 (163)

The biochemistry and function of pannexin channels

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2013
Three family members compose the pannexin family of channel-forming glycoproteins (Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single-membrane channels that are regulated by post-translational modifications, channel intermixing, and sub-cellular expression profiles.
Penuela, Silvia, Gehi, Ruchi, Laird, Dale W.   +2 more
openaire   +2 more sources

Platelet pannexin-1 channels modulate neutrophil activation and migration but not the progression of abdominal aortic aneurysm

Frontiers in Molecular Biosciences, 2023
Abdominal aortic aneurysm (AAA) is a common disease and highly lethal if untreated. The progressive dilatation of the abdominal aorta is accompanied by degradation and remodeling of the vessel wall due to chronic inflammation.
Lisa Maria Metz, Tobias Feige, Larissa de Biasi, Agnes Ehrenberg, Joscha Mulorz, Laura Mara Toska, Friedrich Reusswig, Christine Quast, Norbert Gerdes, Malte Kelm, Hubert Schelzig, Margitta Elvers   +11 more
doaj   +1 more source

PANX2 Suppresses Lung Adenocarcinoma Progression by Inducing Disulfidptosis and Enhancing Antitumor Immunity

Advanced Science, Volume 13, Issue 44, 7 August 2026.
ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen, Zhao‐Yu Liu, Gao‐Wen Qu, Run‐Hao Zeng, Wen‐Xia Yao, Yong‐Bing Zhou, Xue Liang, Yu‐Xiong Lai   +7 more
wiley   +1 more source

Connexins, Pannexins, and Their Channels in Fibroproliferative Diseases [PDF]

The Journal of Membrane Biology, 2016
Cellular and molecular mechanisms of wound healing, tissue repair, and fibrogenesis are established in different organs and are essential for the maintenance of function and tissue integrity after cell injury. These mechanisms are also involved in a plethora of fibroproliferative diseases or organ-specific fibrotic disorders, all of which are ...
Bruno Cogliati, Gregory Mennecier, Joost Willebrords, Tereza Cristina Da Silva, Michaël Maes, Isabel Veloso Alves Pereira, Sara Crespo Yanguas, Francisco Javier Hernandez-Blazquez, Maria Lúcia Zaidan Dagli, Mathieu Vinken   +9 more
openaire   +3 more sources

Contribution of large-pore channels to inflammation induced by microorganisms

Frontiers in Cell and Developmental Biology, 2023
Plasma membrane ionic channels selectively permeate potassium, sodium, calcium, and chloride ions. However, large-pore channels are permeable to ions and small molecules such as ATP and glutamate, among others.
José L. Vega, José L. Vega, José L. Vega, Camila Gutiérrez, Mauro Rojas, Juan Güiza, Juan C. Sáez   +6 more
doaj   +1 more source

An unattended image‐processing pipeline for on‐the‐fly quality assessment and 3D exploration in cryo‐EM

Acta Crystallographica Section D, Volume 82, Issue 8, Page 915-939, August 2026.
We present a fully automated, unattended cryo‐EM pipeline that serves as an on‐the‐fly diagnostic tool, enabling rapid data‐quality assessment and informed decision‐making to maximize data‐collection efficiency.Single‐particle analysis (SPA) by cryogenic electron microscopy (cryo‐EM) has become a cornerstone of structural biology; yet, the workflow ...
Daniel Marchán Torres, Pablo Conesa, Alberto Garcia, Mikel Iceta, Ludovic Broche, Marcos Gragera, Romain Linares, Hok Sau Kwong, Francisco Javier Chichón, Olof Svensson, Rocío Arranz, Grégory Effantin, Eaazhisai Kandiah, José María Carazo, Carlos O. S. Sorzano   +14 more
wiley   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

Glia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat, Alima Ahmed, Mariano Viapiano, Preethi S. Ganapathy   +3 more
wiley   +1 more source

The Multifaceted Role of Pyroptosis: Molecular Mechanisms, Crosstalk with Other Cell Death Pathways, and Therapeutic Implications

MedComm, Volume 7, Issue 7, July 2026.
Pyroptosis maintains immune homeostasis by eliminating damaged or infected cells, but its dysregulation promotes inflammation and cancer progression. The diagram illustrates key activation pathways, links with other programmed cell deaths, and cancer‐specific effects, enhancing its dual protective and pathogenic roles.
Diego Liviu Boaru, Patricia De Castro‐Martinez, Cielo Garcia‐Montero, Oscar Fraile‐Martinez, Majd N. Michael Alhaddadin, Silvestra Barrena‐Blázquez, Laura Lopez‐Gonzalez, Clara Tasende Fernández, Ricardo Alvarado‐Hurtado, Tomás Ratia Giménez, Inmaculada Lasa‐Unzúe, Manuel Díez Alonso, Alberto Gutiérrez‐Calvo, Miguel A. Saez, David Cobo‐Prieto, Jose V. Saz, Melchor Alvarez‐Mon, Raul Diaz‐Pedrero, Miguel A. Ortega   +18 more
wiley   +1 more source

Connexin and pannexin (hemi)channels in the liver [PDF]

Frontiers in Physiology, 2014
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions.
Maes, Michael, Decrock, Elke, Cogliati, Bruno, Oliveira, Andre G., Marques, Pedro E., Dagli, Maria L.Z., Menezes, Gustavo B., Mennecier, Gregory, Leybaert, Luc, Vanhaecke, Tamara, Rogiers, Vera, Vinken, Mathieu   +11 more
openaire   +6 more sources

Mind the gap: connexins and pannexins in platelet function

Platelets, 2021
Connexins are a family of gap junction forming proteins widely expressed by mammalian cells. They assemble into hexameric hemichannels, which can either function independently or dock with opposing hemichannels on apposite cells, forming a gap junction ...
Kirk a Taylor, Gemma Little, Jonathan M. Gibbins   +2 more
doaj   +1 more source