Results 61 to 70 of about 1,937 (148)
Cancer Medicine, Volume 15, Issue 9, September 2026.ABSTRACT Resistance to immune checkpoint blockade (ICB) remains a major barrier in cancer therapy, reflecting the fact that tumor immunity is governed not only by cell type abundance but also by spatial organization and temporal dynamics within the tumor microenvironment (TME).
Shanyi Li +4 more
wiley +1 more source
Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment
MedComm, Volume 7, Issue 9, September 2026.Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu +9 more
wiley +1 more source
USES OF NEURONAL PANNEXINS FOR THERAPY AND DIAGNOSIS IN MAMMALS [PDF]
, 2005 The present invention is related to the use of neuronal pannexins for the manufacture of drugs for preventing and/or treating neurological disorders, particularly neurological disorders involving hippocampal pyramidal cells in mammals.
core
Neural Regeneration Research, 2021 Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclusive ...
Monica L Acosta +6 more
doaj +1 more source
Advanced Science, Volume 13, Issue 44, 7 August 2026.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.Stress‐induced switch. Under stress conditions, small extracellular vesicle release shifts from the constitutive ‘torn bag mechanism’ to exocytosis of multivesicular endosomes. https://BioRender.com/xn1pa1e. ABSTRACT The biogenesis of small extracellular vesicles (sEVs) is only partially understood.
Dorina Lenzinger +18 more
wiley +1 more source
Molecular characterization of pannexins in the lens
, 2006 Cell communication in the lens is critical for the life-long homeostasis of this tissue. Abundant gap junctions and cell-cell fusions are reported to be indispensable to the metabolic requirements and optical properties of the highly interconnected ...
Shestopalov, Valery +3 more
core +4 more sources
Acta Crystallographica Section D, Volume 82, Issue 8, Page 915-939, August 2026.We present a fully automated, unattended cryo‐EM pipeline that serves as an on‐the‐fly diagnostic tool, enabling rapid data‐quality assessment and informed decision‐making to maximize data‐collection efficiency.Single‐particle analysis (SPA) by cryogenic electron microscopy (cryo‐EM) has become a cornerstone of structural biology; yet, the workflow ...
Daniel Marchán Torres +14 more
wiley +1 more source
Frontiers in Cell and Developmental BiologyMultiple studies have demonstrated that acute ethanol consumption alters brain function and cognition. Nevertheless, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez +10 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2015 Pannexin2 (Panx2) is the largest of three members of the pannexin proteins. Pannexins are topologically related to connexins and innexins, but serve different functional roles than forming gap junctions.
Daniela eBoassa +4 more
doaj +1 more source