Results 61 to 70 of about 1,892 (187)
Connexins and Pannexins in cerebral ischemia
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018 A common cause of mortality and long-term adult disability, cerebral ischemia or brain ischemia imposes a significant health and financial burden on communities worldwide. Cerebral ischemia is a condition that arises from a sudden loss of blood flow and consequent failure to meet the high metabolic demands of the brain. The lack of blood flow initiates
Yeri Kim +5 more
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The Cryo-EM structure of pannexin 1 reveals unique motifs for ion selection and inhibition
eLife, 2020 Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such as connexins, innexins ...
Kevin Michalski +5 more
doaj +1 more source
N-Glycosylation Regulates Pannexin 2 Localization but Is Not Required for Interacting with Pannexin 1 [PDF]
International Journal of Molecular Sciences, 2018 Pannexins (Panx1, 2, 3) are channel-forming glycoproteins expressed in mammalian tissues. We previously reported that N-glycosylation acts as a regulator of the localization and intermixing of Panx1 and Panx3, but its effects on Panx2 are currently unknown.
Rafael E. Sanchez-Pupo +2 more
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The Neuroglial Dialog Between Cannabinoids and Hemichannels
Frontiers in Molecular Neuroscience, 2018 The formation of gap junctions was initially thought to be the central role of connexins, however, recent evidence had brought to light the high relevance of unopposed hemichannels as an independent mechanism for the selective release of biomolecules ...
Valeria C. Labra +11 more
doaj +1 more source
The FEBS Journal, EarlyView.Astrocytic gap junctions formed by connexin43 (Cx43) help maintain brain homeostasis. After mild traumatic brain injury (TBI), total cortical Cx43 increases and redistributes toward a soluble, non‐junctional pool with elevated hemichannel activity and increased phosphorylation at serine 368 (pCx43S368).
Carmen Muñoz‐Ballester +11 more
wiley +1 more source
Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury
Frontiers in Molecular Neuroscience, 2019 Mechanical stress and hypoxia during episodes of ocular hypertension (OHT) trigger glial activation and neuroinflammation in the retina. Glial activation and release of pro-inflammatory cytokines TNFα and IL-1β, complement, and other danger factors was ...
Alexey Pronin +11 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley +1 more source
Connexins and pannexins: important players in tumorigenesis, metastasis and potential therapeutics [PDF]
, 2018 Since their characterization more than five decades ago, gap junctions and their structural proteins—the connexins—have been associated with cancer cell growth.
Jiang, Jean +9 more
core +1 more source
Frontiers in Cellular Neuroscience, 2018 A mounting body of evidence indicates that adolescents are specially more susceptible to alcohol influence than adults. However, the mechanisms underlying this phenomenon remain poorly understood.
Gonzalo I. Gómez +13 more
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