Results 81 to 90 of about 1,892 (187)
Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone
, 2016 International audienceElectron micrographs revealed the presence of gap junctions in osteoblastic cells over 40 years ago. These intercellular channels formed from connexins are present in bone forming osteoblasts, bone resorbing osteoclasts, and ...
Amédée, Joëlle +6 more
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The Journal of Physiology, Volume 604, Issue 12, Page 4678-4706, 15 June 2026.Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Igor S. A. Felippe +11 more
wiley +1 more source
Contribution of large-pore channels to inflammation induced by microorganisms
Frontiers in Cell and Developmental Biology, 2023 Plasma membrane ionic channels selectively permeate potassium, sodium, calcium, and chloride ions. However, large-pore channels are permeable to ions and small molecules such as ATP and glutamate, among others.
José L. Vega +6 more
doaj +1 more source
HIF‐Regulated Pannexin‐1 Channel Drives Luminal ATP Accumulation in Kidney Cysts
The FASEB Journal, Volume 40, Issue 10, 31 May 2026.Autosomal dominant polycystic kidney disease causes progressive cyst enlargement in the kidneys, leading to hypoxia and induction of HIF‐1α. Our study identifies HIF‐1α‐dependent transcriptional upregulation of Pannexin1 (PANX1) in the apical membrane of cyst epithelial cells, promoting ATP release into the cyst lumen.
Kathrin Skoczynski +10 more
wiley +1 more source
The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary
Autism Research, Volume 19, Issue 5, May 2026.ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley +1 more source
USES OF NEURONAL PANNEXINS FOR THERAPY AND DIAGNOSIS IN MAMMALS [PDF]
, 2005 The present invention is related to the use of neuronal pannexins for the manufacture of drugs for preventing and/or treating neurological disorders, particularly neurological disorders involving hippocampal pyramidal cells in mammals.
core
Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu +4 more
wiley +1 more source
Neural Regeneration Research, 2021 Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of diseases. Some of these compounds are now in clinical trials, but for many of them, the literature is inconclusive ...
Monica L Acosta +6 more
doaj +1 more source
Connexin and pannexin (hemi)channels in the liver [PDF]
Frontiers in Physiology, 2014 The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions.
Maes, Michael +11 more
openaire +6 more sources
Glial connexins and pannexins in the healthy and diseased brain
, 2021 Over the past several decades a large amount of data have established that glial cells, the main cell population in the brain, dynamically interact with neurons and thus impact their activity and survival.
Naus, Christian C. +8 more
core +1 more source