Results 81 to 90 of about 1,563 (163)

A quantized mechanism for activation of pannexin channels

Nature Communications, 2017
Pannexins are oligomeric plasma membrane channels that allow permeation of ions and large molecules. Here the authors show that human Pannexin 1 activation is a multistep event, where modification of each monomer opens the channel to a unique conductance
Yu-Hsin Chiu, Xueyao Jin, Christopher B. Medina, Susan A. Leonhardt, Volker Kiessling, Brad C. Bennett, Shaofang Shu, Lukas K. Tamm, Mark Yeager, Kodi S. Ravichandran, Douglas A. Bayliss   +10 more
doaj   +1 more source

Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease

Frontiers in Cellular Neuroscience, 2019
Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In addition to this main physiological function, these cells play key roles by providing energy substrates to neurons as well as information required to sustain proper ...
Sebastián Vejar, Juan E. Oyarzún, Juan E. Oyarzún, Mauricio A. Retamal, Mauricio A. Retamal, Fernando C. Ortiz, Juan A. Orellana, Juan A. Orellana   +7 more
doaj   +1 more source

Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Glucose metabolic reprogramming is a central driver of immunosuppression in the tumour microenvironment, orchestrating immune dysfunction through multiple interconnected mechanisms. Glucose competition establishes a selective bioenergetic hierarchy that constrains antitumour immunity, whereas lactate accumulation and its reciprocal crosstalk with ...
Yang Wang, Yijun Lu, Jian Zhou, Xinrong Yang   +3 more
wiley   +1 more source

Connexins and pannexins: from biology towards clinical targets

Swiss Medical Weekly, 2016
Efficient cell communication is a prerequisite for the coordinated function of tissues and organs. In vertebrates, this communication is mediated by a variety of mechanisms, including the exchange of molecules between cells, and between cells and the ...
Paolo Meda, Jacques-Antoine Haefliger
doaj   +1 more source

Connexin Regulation and Modulation of Neural Stem Cell Differentiation Induced by Cell‐Permeable Itaconate

Journal of Cellular Physiology, Volume 241, Issue 5, May 2026.
The immunometabolite itaconate modulates the connexin profile of neural stem cells, and it upregulates Cx36‐based channels, promoting the differentiation toward a neuronal phenotype. These effects were abolished by connexin blockade, supporting a role for itaconate in the neuroimmune axis in inflammatory and neurodegenerative disorders. ABSTRACT Neural
Simona Denaro, Simona Rosa Spina, Simona D'Aprile, Anna Gervasi, Filippo Torrisi, Carmela Parenti, Agata Zappalà, Nunzio Vicario, Rosalba Parenti   +8 more
wiley   +1 more source

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

MedComm, Volume 7, Issue 5, May 2026.
1. Efferocytosis coordinates molecular signaling and metabolic reprogramming to resolve inflammation. 2. Efferocytosis dysfunction underlies four conserved pathological hallmarks across diseases. 3. Therapeutic strategies targeting efferocytosis should be context‐dependent: enhance or inhibit based on disease type. ABSTRACT Efferocytosis—the phagocytic
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
wiley   +1 more source

Pannexin channels in inflammation and tumorigenesis

Frontiers in Cell and Developmental Biology
Pannexin (Panx) channels are oligomeric heptamers of PANX proteins, comprising Panx1, Panx2 and Panx3. These channels facilitate the extracellular release of signaling molecules up to 1.5 kDa in size, including adenosine triphosphate (ATP), amino acids, ions, and other metabolites.
Jiang, Mengmeng, Li, Xiaojia, Xie, Keping   +2 more
openaire   +3 more sources

Role of Connexins and Pannexins in Ischemic Stroke

Current Medicinal Chemistry, 2014
Synaptic plasticity requires careful synchronization and coordination of neurons and glial cells via various mechanisms of intercellular communication. Among them, are those mediated by i) connexin gap junction channels (GJCs), ii) connexin hemichannels and iii) pannexin channels.
Orellana Roca, Juan Andrés, Avendaño, B.C., Montero, T.D.   +2 more
openaire   +5 more sources

Small Cell Lung Cancer Establishes a Metabolic Autocrine Mechanism Through Active Extracellular ATP Transport

Cancer Science, Volume 117, Issue 5, Page 1333-1345, May 2026.
Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda, Manabu Kodama, Keiichi I. Nakayama   +2 more
wiley   +1 more source

Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

Frontiers in Physiology, 2014
In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez, Stephani eVelasquez, Eliseo A Eugenin, Eliseo A Eugenin   +3 more
doaj   +1 more source