Results 101 to 110 of about 1,892 (187)

Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome

Arthritis &Rheumatology, Volume 78, Issue 4, Page 896-903, April 2026.
Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca, Somanathapura K. NaveenKumar, Srilakshmi Yalavarthi, Kavya Sugur, Thalia G. Newman, Claire K. Hoy, Cyrus Sarosh, Jordan K. Schaefer, Ajay Tambralli, Jacqueline A. Madison, Yu Zuo, Fernanda A. Orsi, Michael Holinstat, Jason S. Knight   +13 more
wiley   +1 more source

Pathological Roles of Astrocytes in Traumatic Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu, Yuxiao Ma, Baofeng Wang, Yongtao Zheng, Jie Ren, Qingfang Sun, Liuguan Bian, Yuhao Sun   +7 more
wiley   +1 more source

Role of Connexins and Pannexins in Ischemic Stroke

Current Medicinal Chemistry, 2014
Synaptic plasticity requires careful synchronization and coordination of neurons and glial cells via various mechanisms of intercellular communication. Among them, are those mediated by i) connexin gap junction channels (GJCs), ii) connexin hemichannels and iii) pannexin channels.
Orellana Roca, Juan Andrés, Avendaño, B.C., Montero, T.D.   +2 more
openaire   +5 more sources

Targeting inflammation in cardiometabolic disease: Icosapent ethyl modulates monocyte‐derived macrophages isolated from patients with cardiovascular disease with or without type 2 diabetes

Diabetic Medicine, Volume 43, Issue 4, April 2026.
Abstract Aims Despite intensive lipid‐lowering therapy, individuals with atherosclerotic cardiovascular disease (ASCVD) exhibit residual inflammatory risk, which drives recurrent cardiovascular events. This risk is amplified in type 2 diabetes mellitus (T2DM), where a pro‐inflammatory milieu accelerates atherogenesis. Monocyte‐derived macrophages (MDMs)
J. K. Ward, M. U. Shah, K. Lee, P. E. Squires, C. E. Hills   +4 more
wiley   +1 more source

6‐Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase‐dependent HCO3−/H+/Na+/Ca2+ transport via SLC4As–NHE–NCX–PMCA axis in odontoblasts

The Journal of Physiology, Volume 604, Issue 7, Page 2816-2844, 1 April 2026.
Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Yoshiaki Furusawa, Maki Kimura, Isao Okunishi, Takehito Ouchi, Ryuya Kurashima, Tomoe Katou‐Yamada, Hidetaka Kuroda, Makoto Sugita, Masahiro Furusawa, Yoshiyuki Shibukawa   +9 more
wiley   +1 more source

Roles of connexins and pannexins in (neuro)endocrine physiology [PDF]

, 2015
International audienceTo ensure appropriate secretion in response to organismal demand, (neuro)endocrine tissues liberate massive quantities of hormone, which act to coordinate and synchronize biological signals in distant secretory and non-secretory ...
Hodson, David,, Guérineau, NC, Legros, C, Desarménien, MG, Hodson, David, J, Desarménien, Michel G, Guérineau, Nathalie C, Legros, Christian, Guérineau, Nathalie C., Hodson, DJ, Hodson, David J   +10 more
core   +1 more source

Role of Pannexin-1 hemichannels and purinergic receptors in the pathogenesis of human diseases

Frontiers in Physiology, 2014
In the last decade several groups have determined the key role of hemichannels formed by pannexins or connexins, extracellular ATP and purinergic receptors in physiological and pathological conditions.
Stephani eVelasquez, Stephani eVelasquez, Eliseo A Eugenin, Eliseo A Eugenin   +3 more
doaj   +1 more source

Roles of gap junctions, connexins and pannexins in epilepsy

Frontiers in Physiology, 2014
Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are ...
Shanthini eMylvaganam, Meera eRamani, Michal eKrawczyk, Peter L Carlen   +3 more
doaj   +1 more source

Pannexin channels in inflammation and tumorigenesis

Frontiers in Cell and Developmental Biology
Pannexin (Panx) channels are oligomeric heptamers of PANX proteins, comprising Panx1, Panx2 and Panx3. These channels facilitate the extracellular release of signaling molecules up to 1.5 kDa in size, including adenosine triphosphate (ATP), amino acids, ions, and other metabolites.
Jiang, Mengmeng, Li, Xiaojia, Xie, Keping   +2 more
openaire   +3 more sources

The ins and outs of connexins and pannexins beyond the cell surface

Classically implicated in the transport of small molecules between neighboring cells or into the extracellular milieu, emerging evidence implicates connexins and pannexins in other noncanonical biological functions.
Geli, Maria Isabel, Martins-Marques, Tania, Vasconcelos-Cardoso, Maria, Aasen, Trond, Girao, Henrique, Kwak, Brenda   +5 more
core   +1 more source