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Radial glia at the neurovascular interface during cortical development [PDF]
Frontiers in Cellular NeuroscienceRadial glia are a specialized population of neural progenitor cells that persist throughout embryogenesis and into adulthood. Throughout this period, radial glia reside in a highly dynamic microenvironment that influences various biological decisions ...
Njoud Al-Naama, Caroline Alayne Pearson
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eLife, 2022 The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of infection.
Michael A Kovacs +8 more
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Cells, 2023 Clinical and pre-clinical studies of neuropsychiatric (NP) disorders show altered astrocyte properties and synaptic networks. These are refined during early postnatal developmental (PND) stages.
Eugenia Vivi +3 more
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An open-source tool for automated analysis of breathing behaviors in common marmosets and rodents
eLife, 2022 The respiratory system maintains homeostatic levels of oxygen (O2) and carbon dioxide (CO2) in the body through rapid and efficient regulation of breathing frequency and depth (tidal volume).
Mitchell Bishop +4 more
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Evidence for oligodendrocyte progenitor cell heterogeneity in the adult mouse brain
Scientific Reports, 2022 Oligodendrocyte progenitor cells (OPCs) account for approximately 5% of the adult brain and have been historically studied for their role in myelination.
Rebecca M. Beiter +8 more
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An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]
, 2018 Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura +3 more
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Nature Communications, 2022 Disruption of the blood brain barrier can occur in several diseases. Here the authors show that targeted ablation of astrocytes results in a plasticity mechanism in nearby cells to maintain cerebrovascular coverage, but that this mechanism is impaired in
William A. Mills +9 more
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Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
Nature Communications, 2020 Traumatic brain injury (TBI) is a serious and poorly understood medical condition. Here, the authors show that TBI induces long-lasting deficits in brain lymphatic drainage.
Ashley C. Bolte +12 more
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Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells
Scientific Reports, 2022 Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression.
Courtney R. Rivet-Noor +8 more
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A Comparative Biology of Microglia Across Species
Frontiers in Cell and Developmental Biology, 2021 Microglia are unique brain-resident, myeloid cells. They have received growing interest for their implication in an increasing number of neurodevelopmental, acute injury, and neurodegenerative disorders of the central nervous system (CNS).
Kaushik Sharma +5 more
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