Results 21 to 30 of about 263,899 (349)

Protocol to downregulate GABAergic-astrocyte signaling via astrocyte-selective ablation of GABAB receptor in adult mice

STAR Protocols, 2022
Summary: Here, we present a protocol to selectively downregulate GABAB receptor (GABABR) expression in astrocytes of mouse medial prefrontal cortex (mPFC). We first describe the procedure of surgeries and viral injections.
Sara Mederos, Andrea Sánchez-Ruiz, Gertrudis Perea   +2 more
doaj   +1 more source

Novel role for the innate immune receptor toll-like receptor 4 (TLR4) in the regulation of the wnt signaling pathway and photoreceptor apoptosis [PDF]

, 2012
Recent evidence has implicated innate immunity in regulating neuronal survival in the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons in the retina that are essential for vision.
A Poltorak, A Wenzel, Abigail S. Hackam, AK Silva, AL Kindzelskii, Amit K. Patel, AO Edwards, AS Hackam, B Marsh, BJ Marsh, BJ Marsh, C Bowes, C Liu, C Niehrs, C Zhang, Chhinder P. Sodhi, CP Sodhi, CY Logan, D Jiang, David J. Hackam, DJ Kaczorowski, E Cario, E Chaum, E Okun, F Hua, F Limana, G Faraco, G Tezel, GA Limb, GM Seigel, GR Barile, GS Hageman, GT Higgins, H Yi, H Yi, HL Rosenzweig, HL Rosenzweig, HP Scholl, Hyun Yi, IA El-Ghrably, J Merenmies, J Qiu, J Watson, JK Shen, JR Caso, K Hoshino, K Kaarniranta, K Miyake, K Takeda, KP Mollen, L Barandon, L Minghetti, M Mizukami, MA Fragoso, Mauricio Martins Rodrigues, MD Gordon, MK Ko, MT Lotze, N Arimura, P Matzinger, PJ Franco, PY Leung, Q Xing, R Gauthier, R Gorina, R Kacimi, R Seitz, R Shechter, RM Vabulas, RR Caspi, RT Moon, S Lehnardt, S Lin, S Tell, S Walter, S Zareparsi, SC Gribar, SC Tang, SC Tang, SR Coats, T Ha, T Harada, T Harada, T Nakazawa, U Kilic, V Bocchini, V Fontaine, Y de Kozak, Y Xin, Z Tu   +89 more
core   +8 more sources

Characterizing circulating tumor cells using affinity-based microfluidic capture and AFM-based biomechanics

STAR Protocols, 2022
Summary: Elasticity and bio-adhesiveness of circulating tumor cells (CTCs) are important biomarkers of cancer. CTCs are rare in blood, thus their capture and atomic force microscopy (AFM)-based biomechanical characterization require use of ...
Muhammedin Deliorman, Ayoub Glia, Mohammad A. Qasaimeh   +2 more
doaj   +1 more source

Morphological plasticity of astroglia: Understanding synaptic microenvironment [PDF]

, 2015
Memory formation in the brain is thought to rely on the remodeling of synaptic connections which eventually results in neural network rewiring. This remodeling is likely to involve ultrathin astroglial protrusions which often occur in the immediate ...
Heller, JP, Rusakov, DA
core   +1 more source

Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]

, 2020
Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core   +1 more source

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

Journal of Neuroscience, 2014
The major cell classes of the brain differ in their developmental processes, metabolism, signaling, and function. To better understand the functions and interactions of the cell types that comprise these classes, we acutely purified representative ...
Ye Zhang, Kenian Chen, S. Sloan, Mariko L. Bennett, A. Scholze, S. O’Keeffe, Hemali P. Phatnani, P. Guarnieri, Christine Caneda, N. Ruderisch, Shuyun Deng, S. A. Liddelow, Chaolin Zhang, R. Daneman, T. Maniatis, B. Barres, Jian Wu   +16 more
semanticscholar   +1 more source

SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models

EMBO Molecular Medicine, 2021
Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory environments in disease contexts and thereby contribute to the progression of neuronal loss in neurodegenerative disorders.
Oh-Chan Kwon, Jae-Jin Song, Yunseon Yang, Seong-hoon Kim, Ji Young Kim, Min-Jong Seok, Inhwa Hwang, Je-Wook Yu, Jenisha Karmacharya, H. Maeng, Jiyoung Kim, E. Jho, Seung Yeon Ko, Hyeon Son, M. Chang, Sang-Hun Lee   +15 more
semanticscholar   +1 more source

No Longer Underappreciated: The Emerging Concept of Astrocyte Heterogeneity in Neuroscience

Brain Sciences, 2020
Astrocytes are ubiquitous in the central nervous system (CNS). These cells possess thousands of individual processes, which extend out into the neuropil, interacting with neurons, other glia and blood vessels.
Francisco Pestana, Gabriela Edwards-Faret, T. Grant Belgard, Araks Martirosyan, Matthew G. Holt   +4 more
doaj   +1 more source

Radial glia in the zebrafish brain: Functional, structural, and physiological comparison with the mammalian glia

Glia, 2020
The neuroscience community has witnessed a tremendous expansion of glia research. Glial cells are now on center stage with leading roles in the development, maturation, and physiology of brain circuits.
Nathalie Jurisch-Yaksi, E. Yaksi, C. Kizil   +2 more
semanticscholar   +1 more source

Dynamic resources of the Sanità spring at Caposele (South Italy)

Acque Sotterranee, 2014
The Sanità Spring at Caposele (NE of Campania – South Italy) is the main spring of the Sele river. Since the end of ‘800, it was indicated and was prospected as the possible base of the Acquedotto Pugliese for drinking the dry Apulia zone. The spring was
Massimo V. Civita, Katia Rostagno
doaj   +1 more source