Results 21 to 30 of about 102,413 (266)
Frontiers in Neuroscience, 2017 Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression ...
Sara Pinto +6 more
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Morpho-Functional Consequences of Swiss Cheese Knockdown in Glia of Drosophila melanogaster
Cells, 2021 Glia are crucial for the normal development and functioning of the nervous system in many animals. Insects are widely used for studies of glia genetics and physiology.
Elena V. Ryabova +7 more
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Frontiers in Molecular Neuroscience, 2018 Interactions among endothelial cells (EC) forming blood vessels and their surrounding cell types are essential to establish the blood-brain barrier (BBB), an integral part of the neurovascular unit (NVU).
Victoria A. Malik +2 more
doaj +1 more source
Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
EMBO Molecular Medicine, 2015 Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell autonomously to rod photoreceptor degeneration by primary phagocytosis of ...
Lian Zhao +9 more
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Frontiers in Cellular Neuroscience, 2021 Noradrenaline is a major neuromodulator in the central nervous system (CNS). It is released from varicosities on neuronal efferents, which originate principally from the main noradrenergic nuclei of the brain – the locus coeruleus – and spread throughout
Jérôme Wahis +5 more
doaj +1 more source
Satellite glia modulate sympathetic neuron survival, activity, and autonomic function
eLife, 2022 Satellite glia are the major glial cells in sympathetic ganglia, enveloping neuronal cell bodies. Despite this intimate association, the extent to which sympathetic functions are influenced by satellite glia in vivo remains unclear.
Aurelia A Mapps +10 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Cold Spring Harbor Perspectives in BiologyGlial cells play critical roles in the nervous system. Rather than being passive support cells as long thought, they are highly active participants. Recent work has shed new light on their many functions, include regulation of synapse formation and function, control of neural circuits, and neuro-immune interactions.
Beth Stevens +2 more
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source