Results 11 to 20 of about 160,715 (360)
Nature Communications, 2022 Disruption of the blood brain barrier can occur in several diseases. Here the authors show that targeted ablation of astrocytes results in a plasticity mechanism in nearby cells to maintain cerebrovascular coverage, but that this mechanism is impaired in
William A. Mills +9 more
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Genetic loss of function of Ptbp1 does not induce glia-to-neuron conversion in retina
Cell Reports, 2022 SUMMARY Direct reprogramming of glia into neurons is a potentially promising approach for the replacement of neurons lost to injury or neurodegenerative disorders.
Thanh V. Hoang +9 more
semanticscholar +1 more source
Drosophila ClC-a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits [PDF]
, 2021 Glial cells form part of the neural stem cell niche and express a wide variety of ion channels; however, the contribution of these channels to nervous system develop ment is poorly understood.
Rios, Martín +5 more
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Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Cell, 2020 Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury.
Haibo Zhou +21 more
semanticscholar +1 more source
Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
Nature Communications, 2020 Traumatic brain injury (TBI) is a serious and poorly understood medical condition. Here, the authors show that TBI induces long-lasting deficits in brain lymphatic drainage.
Ashley C. Bolte +12 more
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Stress-induced despair behavior develops independently of the Ahr-RORγt axis in CD4 + cells
Scientific Reports, 2022 Current treatments for major depressive disorder are limited to neuropharmacological approaches and are ineffective for large numbers of patients. Recently, alternative means have been explored to understand the etiology of depression.
Courtney R. Rivet-Noor +8 more
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Stem Cell Research & Therapy, 2013 Twenty years ago glial cells were shown to contribute to neuronal information processing, instead of merely supporting neuronal function, thus challenging the century old neuron doctrine. Due to the lack of appropriate experimental models, however, determining the role of glia in higher brain function and disease has been hampered.
Spitzer, Sonia +2 more
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A Comparative Biology of Microglia Across Species
Frontiers in Cell and Developmental Biology, 2021 Microglia are unique brain-resident, myeloid cells. They have received growing interest for their implication in an increasing number of neurodevelopmental, acute injury, and neurodegenerative disorders of the central nervous system (CNS).
Kaushik Sharma +5 more
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Nature Neuroscience, 2020 The human cortex comprises diverse cell types that emerge from an initially uniform neuroepithelium that gives rise to radial glia, the neural stem cells of the cortex.
Ugomma C. Eze +4 more
semanticscholar +1 more source
Enteric glia: the most alimentary of all glia [PDF]
The Journal of Physiology, 2016 AbstractGlia (from Greek γλοία meaning ‘glue’) pertains to non‐neuronal cells in the central (CNS) and peripheral nervous system (PNS) that nourish neurons and maintain homeostasis. In addition, glia are now increasingly appreciated as active regulators of numerous physiological processes initially considered exclusively under neuronal regulation.
Vladimir Grubišić, Brian D. Gulbransen
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