Results 41 to 50 of about 160,715 (360)
Cold Spring Harbor Perspectives in Biology, 2015 Although the ultrastructure of peripheral nerves has been known for nearly 200 years, the developmental origins and functional roles of all five main components of these specialized nervous system conduits are still poorly understood. One of these understudied nerve elements, the perineurium, is a component of the blood-nerve barrier and is essential ...
openaire +2 more sources
Stroke propensity in the Th3+/ mouse model of β-thalassemia intermedia
Neurobiology of Disease, 2022 β-thalassemia is associated with multiple hematological and cerebrovascular symptoms linked to a hypercoagulable state that has not been fully replicated in animal models for the development of stroke treatments.
Yu-Yo Sun +5 more
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Neuron–glia interactions in the pathophysiology of epilepsy
Nature Reviews Neuroscience, 2019 Epilepsy is a neurological disorder afflicting ~65 million people worldwide. It is caused by aberrant synchronized firing of populations of neurons primarily due to imbalance between excitatory and inhibitory neurotransmission.
Dipan C. Patel +3 more
semanticscholar +1 more source
Science Translational Medicine, 2021 Description TLR4-induced enteric glia loss leads to experimental NEC through BDNF loss, which can be treated with by compound J11. NEC takes its Toll Toll-like receptor-4 (TLR4) has been implicated in the pathophysiology of necrotizing enterocolitis (NEC)
M. Kovler +13 more
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Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]
, 2014 Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana +17 more
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Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation
Cell Reports, 2020 SUMMARY Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the gastrointestinal tract, but the signaling processes that link immune activation with visceral hypersensitivity are unresolved.
Vladimir Grubišić +11 more
semanticscholar +1 more source
Glia as sculptors of synaptic plasticity
Neurosciences research, 2020 Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain development and function. Three major classes of glia in the central nervous system (CNS) include astrocytes, microglia and oligodendrocytes.
L. Sancho +2 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2017 Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset neurodegenerative disorder affecting motor neurons (MNs). Evidences indicate that ALS is a non-cell autonomous disease in which glial cells participate in both disease onset and progression ...
Sara Pinto +6 more
doaj +1 more source
Morpho-Functional Consequences of Swiss Cheese Knockdown in Glia of Drosophila melanogaster
Cells, 2021 Glia are crucial for the normal development and functioning of the nervous system in many animals. Insects are widely used for studies of glia genetics and physiology.
Elena V. Ryabova +7 more
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Frontiers in Molecular Neuroscience, 2018 Interactions among endothelial cells (EC) forming blood vessels and their surrounding cell types are essential to establish the blood-brain barrier (BBB), an integral part of the neurovascular unit (NVU).
Victoria A. Malik +2 more
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