Results 51 to 60 of about 263,899 (349)
Glia as sculptors of synaptic plasticity.
Neurosciences research, 2020 Glial cells are non-neuronal cells in the nervous system that are crucial for proper brain development and function. Three major classes of glia in the central nervous system (CNS) include astrocytes, microglia and oligodendrocytes.
L. Sancho +2 more
semanticscholar +1 more source
Enteric glia in homeostasis and disease: From fundamental biology to human pathology
iScience, 2021 Summary Glia, the non-neuronal cells of the nervous system, were long considered secondary cells only necessary for supporting the functions of their more important neuronal neighbors.
Harry J. Rosenberg, M. Rao
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2021 Noradrenaline is a major neuromodulator in the central nervous system (CNS). It is released from varicosities on neuronal efferents, which originate principally from the main noradrenergic nuclei of the brain – the locus coeruleus – and spread throughout
Jérôme Wahis +5 more
doaj +1 more source
A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis
Nature NeuroscienceSleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial oxidation and lipid accumulation that is dependent on prior wake and ...
Paula R. Haynes +7 more
semanticscholar +1 more source
Neuron-Glia Interactions in Neurodevelopmental Disorders
Cells, 2020 Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric diseases, and that glial cells participate in synapse formation, development, and plasticity.
Y. Kim, Juwon Choi, Bo-Eun Yoon
semanticscholar +1 more source
Neuron, 2007 Whether CNS glial cells play an important role in the regulation of complex behaviors has been a longstanding question. In this issue of Neuron, Suh and Jackson demonstrate a circadian rhythmicity in glial expression of ebony, an N-beta-alanyl-biogenic amine synthase, and show that Ebony activity in glia is essential for the proper regulation of ...
Emery, Patrick, Freeman, Marc R.
openaire +3 more sources
Microglial phagocytosis of living photoreceptors contributes to inherited retinal degeneration
EMBO Molecular Medicine, 2015 Retinitis pigmentosa, caused predominantly by mutations in photoreceptor genes, currently lacks comprehensive treatment. We discover that retinal microglia contribute non‐cell autonomously to rod photoreceptor degeneration by primary phagocytosis of ...
Lian Zhao +9 more
doaj +1 more source
Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation [PDF]
, 2018 Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Mennerick, Steven +3 more
core +3 more sources
Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia
Glia, 2021 NG2 glia display wide proliferation and differentiation potential under physiological and pathological conditions. Here, we examined these two features following different types of brain disorders such as focal cerebral ischemia (FCI), cortical stab ...
Denisa Kirdajova +12 more
semanticscholar +1 more source
Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement
Frontiers in Neural Circuits, 2021 Astrocytes elicit transient Ca2+ elevations induced by G protein-coupled receptors (GPCRs), yet their role in vivo remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established ...
Youichi Iwai +12 more
doaj +1 more source