Results 31 to 40 of about 1,892 (187)
Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation [PDF]
Journal of Cell Science, 2010 Pannexin (Panx) 1 and Panx3 are integral membrane proteins that share some sequence homology with the innexin family of invertebrate gap junctions. They are expressed in mammalian skin. Pannexins have been reported to form functional mechanosensitive single-membrane channels, but their importance in regulating cellular function is poorly understood. In
Steven J, Celetti +5 more
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Channel plan: control of adaptive immune responses by pannexins [PDF]
Trends in ImmunologyIgor Santiago-Carvalho +2 more
exaly +2 more sources
Connexins and Pannexins-Similarities and Differences According to the FOD-M Model. [PDF]
Biomedicines, 2022 Connexins and pannexins are the transmembrane proteins of highly distinguished biological activity in the form of transport of molecules and electrical signals.
Roterman I +3 more
europepmc +2 more sources
A review of the current state of pannexin channels as they relate to the blood vessel wall
Journal of Medical Sciences, 2017 Pannexin proteins comprise a family of channels whose sole function, to date, is the release of nucleotides (e.g., adenosine 5'-triphosphate [ATP] and uridine 5′-triphosphate [UTP]).
Brant E Isakson
doaj +1 more source
Role of connexins and pannexins in cardiovascular physiology [PDF]
, 2021 Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology.
Duffy, Heather +2 more
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Pannexins in Acute Kidney Injury [PDF]
Nephron, 2019 Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently effluxes ATP and plays a central role in the progression of inflammatory ...
Nabin, Poudel, Mark D, Okusa
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The emerging Pannexin 1 signalome: a new nexus revealed?
Frontiers in Cellular Neuroscience, 2014 Pannexins (Panxs) are a family of single-membrane, large-pore ion and metabolite permeable channels. Of the three Panx proteins, Panx1 has been most extensively studied, and has recently emerged as an exciting, clinically relevant target in many ...
Leigh Elizabeth Wicki-Stordeur +4 more
doaj +1 more source
Calcium Signaling in the Photodamaged Skin: In Vivo Experiments and Mathematical Modeling
Function, 2022 The epidermis forms an essential barrier against a variety of insults. The overall goal of this study was to shed light not only on the effects of accidental epidermal injury, but also on the mechanisms that support laser skin resurfacing with intra ...
Viola Donati +8 more
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Gap junctions, pannexins and pain [PDF]
Neuroscience Letters, 2019 Enhanced expression and function of gap junctions and pannexin (Panx) channels have been associated with both peripheral and central mechanisms of pain sensitization. At the level of the sensory ganglia, evidence includes augmented gap junction and pannexin1 expression in glial cells and neurons in inflammatory and neuropathic pain models and increased
David C, Spray, Menachem, Hanani
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Analysis of a pannexin 2-pannexin 1 chimeric protein supports divergent roles for pannexin C-termini in cellular localization [PDF]
Cell Communication & Adhesion, 2013 Pannexins (Panxs) are a three-member family of large pore ion channels permeable to ions and small molecules. Recent elegant work has demonstrated that the Panx1 C-terminus plays an important role in channel trafficking. Panx2, another family member, has a longer and highly dissimilar C-terminus.
Leigh E, Wicki-Stordeur +2 more
openaire +2 more sources